Michael Jardine
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PHSI3011 13-1 Circadian Rhythm and Disease

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Michael Jardine
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PHSI3011 13-1 Circadian Rhythm and Disease

PHSI3011 13-1 Circadian Rhythm and Disease

Question 1 of 11

1

The SCN is [primarily?] responsible for heaps of the Circadian Rhythm stuff. What is it?

Select one of the following:

  • Sagittal Central Nucleus

  • SupraCentral Nucleus

  • Sagittal Cortical Nucleus

  • SupraCortical Nucleus

  • SupraChiasmal Nucleus

  • Sagittal Chiasmal Nucleus

Explanation

Question 2 of 11

1

The CLOCK and BMAL1 genes are downregulated through negative feedback from which of the following?

Select one or more of the following:

  • PER

  • CRY

  • RORa

  • CCGs

Explanation

Question 3 of 11

1

Deepest sleep [normally] occurs at what time?

Select one of the following:

  • 12am

  • 1am

  • 2am

  • 3am

  • 4am

  • 4:30am

  • 6am

  • 6:30am

Explanation

Question 4 of 11

1

Jet lag results in a desynchrony between the sleep-wake cycle and the Melatonin rhythm on:

Select one of the following:

  • Blood transcriptome

  • Plasma transcriptome

  • Renal transcriptome

  • Mitochondrial transcriptome

Explanation

Question 5 of 11

2

Human circadian rhythm disorders that maintain a stable entrainment in relation to the 24-hour day-night cycle include:

Select one or more of the following:

  • Delayed Sleep Phase Disorder (DSPD)

  • Advanced Sleep Phase Disorder (ASPD)

  • Non-24-Hour Sleep-Wake Syndrome

  • Irregular Sleep-Wake Rhythm (ISWR)

  • Shift Work Sleep Syndrome

  • Time Zone Change Syndrome

  • Free-Running Disorder (FRD)

Explanation

Question 6 of 11

1

Free-Running Disorder (FRD) is:

Select one of the following:

  • A progressive pattern of 1- to 2- hour delays in sleep onset and wake times

  • Temporally disorganised and variable episodes of sleeping and waking behaviour with short sleep periods of a few hours that are distributed randomly through the day and night

  • Somnambulism

  • Sleepwalking

Explanation

Question 7 of 11

1

The endogenous cycle is how many hours?

Select one of the following:

  • 23

  • 24

  • 25

Explanation

Question 8 of 11

1

Mutations in CLOCK or PER3 can result in Delayed Sleep Phase Disorder (DSPD). This has been associated with metabolic & psychiatric disorders (e.g. depression, schizophrenia), but is also associated with which of the following:

Select one of the following:

  • Extreme eveningness preference

  • Extreme morningness preference

Explanation

Question 9 of 11

1

Treatments of human circadian rhythm disorders include:

Select one or more of the following:

  • Timed melatonin administration

  • Phase resetting – bright light administration

  • Melatonin agonists

  • Toughening the fuck up

Explanation

Question 10 of 11

1

Disruption of circadian rhythms can lead to:

Select one or more of the following:

  • Metabolic Imbalance

  • Disruption in melatonin levels

  • Disruption in blood glucose levels

  • Insulin resistance

  • Crankiness

Explanation

Question 11 of 11

1

True or false: Circadian rhythm disruptions have been linked to cancer.

Select one or more of the following:

  • True

  • False

  • ...true AND false.

Explanation

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