Michael Jardine
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PHSI3011 10-2 Adipose in Metabolism

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Michael Jardine
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PHSI3011 10-2 Adipose in Metabolism

Question 1 of 27

1

Of the 5 cell types of adipose tissue, which are counted as the “stromal vascular fraction”?

Select one or more of the following:

  • Adipocytes

  • Fibroblasts

  • Preadipocytes

  • Vascular endothelial cells

  • Immune cells (e.g. macrophages)

Explanation

Question 2 of 27

1

What proportion of the volume of adipose tissues is taken up by Adipocytes (as opposed to Fibroblasts, Preadipocytes, Vascular endothelial cells, Immune cells)?

Select one of the following:

  • 20%

  • 40%

  • 60%

  • 80%

Explanation

Question 3 of 27

1

Select from the dropdown lists to complete the text.

What is the effect of Insulin on each of the following things within Adipose tissue?
Glucose uptake: ( Stimulate, Inhibit )
Fatty Acid synthesis: ( Stimulate, Inhibit )
Fatty Acid storage: ( Stimulate, Inhibit )
Protein synthesis: ( Stimulate, Inhibit )
Fatty Acid release: ( Stimulate, Inhibit )

Explanation

Question 4 of 27

1

Adipocytes make triglycerides from which of the following:

Select one or more of the following:

  • Glucose

  • Fatty Acids

  • Cholesterol

Explanation

Question 5 of 27

1

Adipocytes release adipokines like Leptin. Leptin is an example of which of the following:

Select one of the following:

  • Lipids

  • Hormones

  • Peptides

  • Cytokines

Explanation

Question 6 of 27

1

Adipokines include which of the following:

Select one or more of the following:

  • Lipids

  • Hormones

  • Peptides

  • Cytokines

Explanation

Question 7 of 27

1

Adipokines have been shows to influence which of the following:

Select one or more of the following:

  • Metabolism

  • Food intake

  • Energy expenditure

  • Inflammation

Explanation

Question 8 of 27

1

True or false: Adipokines are secreted from adipocytes, but can also be secreted from other sites.

Select one of the following:

  • True
  • False

Explanation

Question 9 of 27

1

Which gene is missing in the obese “OB” mouse?

Select one of the following:

  • Leptin

  • Adiponectin

  • GLUT4

Explanation

Question 10 of 27

2

Select from the dropdown lists to complete the text.

Leptin is released from the adipose tissue, then communicates with the ( Hypothalamus, Hippocampus ) to ( SUPPRESS energy intake, INCREASE energy intake )/( SUPPRESS energy expenditure, INCREASE energy expenditure ).

Explanation

Question 11 of 27

1

True or false: Most obese people are Leptin-deficient.

Select one of the following:

  • True
  • False

Explanation

Question 12 of 27

1

Define Lipodystrophy:

Select one of the following:

  • LACK of fat (in adipose tissue)

  • EXCESS of fat (in adipose tissue)

  • DISRUPTION of function of fat (in adipose tissue)

  • EXCESSIVE function of fat (in adipose tissue)

Explanation

Question 13 of 27

1

Select from the dropdown list to complete the text.

Leptin is a key hormone released from adipose tissue and is involved in ( Glucose, Lipid, Neither, Both ) metabolism in the WHOLE BODY.

Explanation

Question 14 of 27

1

True or false: Leptin therapy is a promising mode of treatment for most obese patients.

Select one of the following:

  • True
  • False

Explanation

Question 15 of 27

1

True or false: Leptin therapy is a promising mode of treatment for patients with Type 1 Diabetes.

Select one of the following:

  • True
  • False

Explanation

Question 16 of 27

1

True or false: Leptin therapy is a promising mode of treatment for patients with Type 2 Diabetes.

Select one of the following:

  • True
  • False

Explanation

Question 17 of 27

1

Select from the dropdown list to complete the text.

The adipokine Adiponectin is one of the most highly secreted proteins in our blood. Its secretion is generally ( Reduced, Increased, Unaffected ) in obesity.

Explanation

Question 18 of 27

1

Select from the dropdown list to complete the text.

( Adiponectin, Leptin, Both of the above, Neither of the above ) acts to stimulate AMP-kinase to increase β-oxidation [and] increase glucose uptake into the cell.

Explanation

Question 19 of 27

1

True or false: In addition to being stimulated by some adipokines, AMP-kinase is also regulated by exercise, to stimulate energy expenditure within a cell.

Select one of the following:

  • True
  • False

Explanation

Question 20 of 27

1

Hypertrophy vs Hyperplasia (with a view on adipocytes)
Hypertrophy = increase in ;
Hyperplasia = increase in .

Drag and drop to complete the text.

    Size
    Number

Explanation

Question 21 of 27

1

True or false: Ectopic Lipid Accumulation is the “spill over” when adipocytes reach saturation and lipids start getting into other tissues (e.g. muscle, liver) where it causes metabolic dysfunction.

Select one of the following:

  • True
  • False

Explanation

Question 22 of 27

1

True or false: Lipodystrophy is the “spill over” when adipocytes reach saturation and lipids start getting into other tissues (e.g. muscle, liver) where it causes metabolic dysfunction.

Select one of the following:

  • True
  • False

Explanation

Question 23 of 27

1

Which of the two distributions are more strongly associated with metabolic disease?
“Android” distribution – more around the upper body;
“Gynoid” distribution – more around the lower body.

Select one of the following:

  • Gynoid

  • Android

Explanation

Question 24 of 27

1

True or false: BMI = Body Mass Index; WHR = Waist-Hip Ratio

Select one of the following:

  • True
  • False

Explanation

Question 25 of 27

1

Someone with a higher upper-body fat distribution will need to __________ in order to maintain homeostasis.

Select one of the following:

  • Secrete MORE insulin

  • Secrete LESS insulin

  • Absorb MORE insulin

  • Absorb LESS insulin

Explanation

Question 26 of 27

1

True or false: Chronic inflammation often correlates with obesity because there’s increased migration of macrophages into the ADIPOSE tissue.

Select one of the following:

  • True
  • False

Explanation

Question 27 of 27

1

Which of the following are associated with [adipose] hypertrophy and [adipose] hyperplasia?

Select one or more of the following:

  • Hypoxia

  • Fibrosis

  • Inflammation

Explanation

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