T or F. African Americans respond better to a Thiazide diuretic.
T or F. Beta blockers are 1st line drugs for HTN.
Select all that apply. Which of the following are thiazide diuretics.
HCTZ
Indapamide
Lasix
Spironolactone
Metolazone
Which class of diuretics inhibits distal convoluted tubule sodium and chloride re-absorption?
Loop
Potassium Sparing
Potassium Wasting
Select all that apply. Which of the following electrolyte imbalances can occur with thiazide diuretics?
Hypokalemia
Hypehalemia
Hypercalcemia
Hypocalcemia
Hyponatremia
Hypernatremia
Hypomagnesemia
Hypermagnesemia
Chlorthalidone and indapamide, are longer acting thiazide diuretics, more potent than HCTZ and carry a higher risk for hypokalemia.
A dose of HCTZ greater than _____mg has an increased risk for hypokalemia.
30mg
70mg
50mg
60mg
What should the NP monitor when a patient is on thiazide diuretics? Select all that apply.
BUN
Serum Creatinine or CrCl
Heart rate
Blood pressure
Vision changes
Electrolytes
T or F. Thiazide diuretics are commonly combined with other anti-hypertensives.
T or F. Thiazide diuretics are contraindicated in persons with gout as they increase uric acid.
T or F. Loop diuretics are used more often for edema than HTN.
The following are exemplar Loop Diuretics:
Lisinopril
Bumetanide
Toresemide
Identify the MOA for loop diuretics from the choices below:
Inhibits distal convoluted tubule Na+ and Cl reabsorption
Inhibits Loop of Henle and proximal/distal convoluted tubule Na+ and Cl reabsorption
Stops the conversion of Angiotensin I to Angiotensin II
Loop diuretics are contraindicated in patients with:
Shellfish allergies
Sulfa allergies
Diabetes
Edema
Loop diuretics:
Increase K+ and decrease Urea
Increase WBG
Decrease K+ and Increase Urea
Increase neutrophils
T or F. Potassium Sparing Diuretics have weak diuretic activity.
Exemplars of Potassium Sparing Diuretics Includes: (select all that apply)
Triameterene
Bumentanide
Spironalactone
Eplerenone
Spironolactone:
Decreases K+ and Urea
Increases K+ and decreases Urea
Increases K+ and Urea
Increases Na+
Lisinopril should be d/c if serum K+ increases more than?
40%
15%
20%
30%
Which ACE is not used often for maintenance therapy d/t a short half-life and multiple dosing?
Benazepril
Catorpil
Ramipril
If a patient is at high risk for renal artery stenosis, how soon after initiating ACEI should the patient's Cr be checked?
1 week
1 month
48 hours
3-5 days
Which patient populations have a greater risk of developing angioedema with the use of ACEI? Select all that apply.
Asian
Latino
Pacific Islander
Caucasian
African American
ACEI therapy is preferred for the following populations (select all that apply):
Patient's with Diabetic Kidney Disease
Pregnant Women
Patients with DM
Young patients
Patients who are Post MI
Patients with Heart Failure
Patients with Angina
ACEI and ARBS can have the following additional positive effects (select all that apply):
Improve oxygenation to the heart
Decrease inappropriate remodeling of heart muscle after MI
Reduce effects of diabetes on the kidneys
Improve insulin sensitivity
All of the Above
What is a possible inconvenient but not life threatening adverse reaction from ACEI therapy?
Itching
Bradykinin mediated cough
Tachycardia
ACEI can increase K+
An increase in Cr with ACEI therapy is often transient.
What is the most common adverse reaction to ACEI therapy?
SOB
Hypotension
Bradycardia
Fever
The following are exemplars for ARBS (select all that apply)
Losartan
Amlodipine
Valsartan
Verapamil
Olmesartan
ARBS prevent the binding of Angiotensin II to receptors in the kidneys, brain, heart and arterial walls-inhibit RAAS and cause fall in peripheral resistance.
ARBS may never be combined with which class of drug?
Thiazide diuretics
ACEI
CC Blockers
Direct Renin Inhibitors
ACEI and ARBS should be avoided in:
Women who are pregnant or may become pregnant
Menopausal women
The elderly
ARBS can be a good choice for patients with Gout because:
There is decreased uric acid secretion
Increased uric acid secretion
T or F. ARBS can raise serum K+.
The Direct Renin Inhibitor Tekturna shares this possible side effect with ACEI.
Increased WBG
Angioedema
Cough
Decreased K+
T or F. Tekturna can increase serum K+.
T or F. ARBS are contraindicated in patients with Renal Artery Stenosis.
T or F. You can combine ACEI, ARBS and DRI.
The following is true of dihydropyridine CCB (select all that apply):
Are potent vasodilators that lower calcium influx into the smooth muscle.
Have little or no negative effect on cardiac contractility and conduction.
Can treat chronic stable angina
Can be used in patients with CHF
Dihyropyridine CCB include (select all that apply)
Norvasc
Nifedipine
Felodipine
T or F. Peripheral edema can be caused by amlodipine.
Which class of drugs can be combined with Amlodipine to reduce peripheral edema?
ARBS
DRI
ACES
Thiazide Diuretics
Dihyrdopyridine CCB have greater efficacy in African Americans.
T or F. ACEI can never be prescribed to African Americans.
The following is true of non-dihyrdopyridine CCB (select all that apply):
Can treat A-fib
Can be effective in proteinuria reduction.
Have a depressive effect on cardiac contractility and conduction
Should be avoided in patients who are taking beta blockers
T or F. Verapamil has the strongest inotropic effect of the non-dihyrdopyridine CCB and should be avoided in patients with Heart Failure.
Verapamil can interact with the following (select all that apply):
Simvastatin
Lithium
Amiodarone
Codeine
T or F. Beta blockers are 1st line in the treatment of HTN.
Cardio-selective beta-blockers include (select all that apply):
Atenolol
Metropolol
Coreg
Propranolol
Bisoprolol
Esmolol
Acebutolol
Propranolol is a non-cardioselective beta-blocker that is used for symptom management with which endocrine issue:
Hypothyroidism
Hyperthyroidism
T or F. CCB and Beta-blockers can used for prophylactic treatment of migraines.
T or F. Beta-blockers are superior protection against stroke.
An example of mixed alpha and beta blocker is:
Carvedilol (coreg)
Nadolol
What is major consideration when prescribing a beta-blocker in a patient with DM?
It can mask hypogylcemia
It can cause tachycardia
Can improve blood glucose
Protects against strokes
In a patient with decompensated bronchospastic disease with stable angina, the NP should prescribe:
A beta-blocker
A cardio-selective dihydropyridine
Aspirin
S/E of beta-blockers can include (select all that apply):
Fatigue
Depression
2nd and 3rd degree AV Block
T or F. Discontinuation of beta-blockers needs to occur over a few weeks.
Clonodine belongs to which class of anti-hypertensives?
Beta-blockers
Centrally Acting Agents
Centrally acting agents can be used to treat which condition in pediatric patients.
Dry Mouth
ADHD
Dizziness
Possible Adverse Reactions to Centrally Acting Agents includes (select all that apply):
Dry mouth
Lightheadedness
Rash
Hypoglycemia
Bradycarida
T or F. Patients wanting to come off of clonidine need to be tapered due to risk for rebound HTN.
Methyldopa is indicated in which population?
Elderly
Pregnant women
Adolescents
African Amercians
A contraindication for Methyldopa is:
Kidney Disease
DM
CHF
Active Hepatic Disease
T or F. The MOA of methyldopa is it stimulates the Alpha 2 adrenergic receptors.
Prazosin a peripherally acting agent, while not a 1st line anti-hypertensive is effective in treating:
Anigna
HF
PTSD and associated night terrors
T or F. Doxazosin should be taken at bedtime due to risk for postural lightheadedness.
The following should be avoided in pregnancy (select all that apply):
Sprionolactone
Methyldopa
In addition to methyldopa, which two other drugs are commonly used for HTN in pregnancy:
Lisinopril and Clonidine
Norvasc and Tekturna
Losartan and Spironalactone
Labetalol and Nifedipine
T or F. Betablockers are not recommended as initial therapy in children.
Which class of diuretics is used in fluid volume overload?
Thiazide
When using Digoxin to treat Stage C Heart Failure, the NP knows which medicine can upset the narrow therapeutic index of the drug:
Diltiazem
Benazapril
ASA
T or F. Digoxin increases myocardial contractility.
The therapeutic index for digoxin is:
0.10-0.20
0.1-0.3
0.5-0.9
0.3-0.8
T or F. Low K+ and Mg+ and high Ca+ increase the risk for digoxin toxicity.
Signs of toxicity to tell your patient who is taking digoxin are (select all that apply):
Seeing green and yellow halos
Delirium and confusion
Insomina
Weakness
HMG CoA reductase inhibitors are more commonly known as:
Statins
Fibrates
Omega 3 Fatty Acids
The primary treatment goal of statins is to:
Increase LDL
Increase HDL
Decrease LDL
Increase Liver Function
T or F. It is fine for pregnant women or women planning to become pregnant to take simvastatin.
Which group of patients could benefit from statins:
Age 21 years> with an LDL>190
Patients with active liver disease
African American Females
Smokers
Statins should be discontinued if which lab value if it is >3x the normal value?
GGT
TSH
ALT
WBG
There is an increased risk of myopathy/rhabdomyolysis with which drug interactions:
gemfibrozil and statins
Statins and ACEI
Beta-blockers and Statins
Calcium channel blockers and statins
What lab level should be checked if a patient complains of muscle pain while taking a statin?
Vitamin D
B12
Platelets
Hgb
T or F. New onset DM is less common with pravastatin and pitavastatin.
Before changing a patient to new statin. the NP should ensure the patient has been adhering to their current statin medication by checking:
BP
CMP
Lipid panel
Fasting Blood Glucose
T or F. Short acting statins like Lovastatin should be taken at bedtime?
Lower doses of rosuvastatin is recommended in which population?
African Americans
Latinos
Canadians
Asians
One of the advantages of zetia over statins is:
You can give it to children younger than 10 y/o
It is indicated for use in pregnant women
It raises HDL
It raises LDL
T or F. The MOA of Zetia is the inhibition of cholesterol at the small intestine.
PCSK9 Inhibitors like Alirocumab and Evolocumab:
Are inexpensive
Are powerful at lowering LDL
Are less effective than statins
Can be taken orally
T or F. Alirocumab must be stored in the refrigerator.
T or F. PCSK9 inhibitors should be avoided in pregnancy.
What is one way to decrease the flushing side effect that can come with the use of Niacin?
Take it with milk
Take it at bedtime
Take 325mg ASA 30 minutes before
Take it on an empty stomach
T or F. Fibrates are only taken to reduce high triglycerides.
Gemfibrozil and Fenofibrate should not be taken with statins because:
Increased risk for heart palpitations
Increase risk for drug interactions
They potentiate each other
Causes flushing
Fibrates should be avoided in (Select all that apply)
Hepatic Impairment
Lactation
Pregnancy
In children over age 10 with Triglycerides >500
T or F. Statins can be used in children older than age ten with an elevated LDL.
Omega 3 Fatty Acids are helpful in reducing:
Trigylcerides
HDL
Muscle Pain