Michael Jardine
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PHSI3011 08-1 Hormonal control of bone (PTH and sex steroids)

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Michael Jardine
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PHSI3011 08-1 Hormonal control of bone (PTH and sex steroids)

Question 1 of 13

1

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( Decreased, Increased ) serum Calcium – sensed by Calcium-sensing Receptor (CaR) in the ( ParaThyroid Gland, Hypothalamus, Thyroid Gland ) triggers release of PTH.

Explanation

Question 2 of 13

1

In response to decreased serum Calcium, PTH is released and goes to which of the following?

Select one or more of the following:

  • Kidney

  • Bone

  • Gut

  • Muscle

  • Liver

Explanation

Question 3 of 13

1

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In the kidney, what PTH has 3 effects. These are:
a: ( Increase, Decrease ) 1,25 (OH)2 D;
b: ( Increase, Decrease ) Ca reabsorption;
c: ( Increase, Decrease ) PO4 reabsorption;

Explanation

Question 4 of 13

1

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In the bone, PTH has 2 effects. These are:
a: ↑ ( Osteoclasts, Osteoblasts, Osteocytes, Lining Cells );
b: ↑ Bone ( Resorption, Formation ) (releasing Ca).

Explanation

Question 5 of 13

1

PTH-1 is a class-B GPCR. Yeah?

Select one of the following:

  • Yeah

  • Nah

Explanation

Question 6 of 13

1

The primary effect of Hyperparathyroidism is:

Select one of the following:

  • Increase blood Ca

  • Decrease blood Ca

  • Increase kidney Ca

  • Decrease kidney Ca

Explanation

Question 7 of 13

1

PROLONGED increase of PTH results in which of the following:

Select one or more of the following:

  • Increased osteoclasts

  • Decreased osteoclasts

  • Increased osteocytes

  • Decreased osteocytes

  • Increased bone resorption

  • Increased bone formation

  • Bone loss

  • Bone gain

Explanation

Question 8 of 13

1

The main effect of INTERMITTENT PTH is:

Select one or more of the following:

  • Increased osteoblast numbers

  • Increased osteoclast numbers

  • Decreased osteoblast numbers

  • Decreased osteoclast numbers

Explanation

Question 9 of 13

1

True or false: Intermittent PTH has little effect on osteoclasts, although they are necessary for its action.

Select one of the following:

  • True
  • False

Explanation

Question 10 of 13

1

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Sclerostin is a ( Negative, Positive ) regulator of bone formation.

Explanation

Question 11 of 13

1

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Mutations that inactivate Sclerostin cause ( Increased, Decreased ) bone mass.

Explanation

Question 12 of 13

1

Sclerostin is produced by which of the following:

Select one or more of the following:

  • Osteocytes

  • Osteoclasts

  • Osteoblasts

  • Lining Cells

  • PTH

Explanation

Question 13 of 13

2

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Intermittent PTH ( Decreases, Increases ) sclerostin. Sclerostin ( Inhibits, Stimulates ) Wnt signaling. Therefore Intermittent PTH has a ( Positive, Negative ) effect on Wnt signalling and results in ( Increased, Decreased ) bone formation (and ( Decreased, Increased ) bone resorption).

Explanation

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