PHSI3012 10-2 Disorders of Lipid Metabolism #2 (T3L2)

Question 1 of 8

2

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Cholesterol is a 26-Carbon sterol lipid that’s synthesised through a complex 37-step process.
It composes ( 10%, 30%, 50%, 70%, 90% ) of cell membranes.
Circulating cholesterol arises from the diet as well as from ( Intracellular, Extracellular, Intercellular ) synthesis.
It circulates mostly as Cholesterol Ester (cholesterol + FA).

Explanation

Question 2 of 8

2

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Familial Hypercholesterolaemia is a family of pathologies that range from heterozygous to homozygous. It’s characterised by ( Increased, Decreased ) ( LDL-Chol, HDL-Chol ) levels. Caused by a loss of LDL-R.

Explanation

Question 3 of 8

2

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Lysosomal Storage Disease (aka Niemann-Pick disease type C) is a collection of ~50 rare inherited metabolic pathologies. Its hallmark is defective lysosomal function. It’s characterised by ( Free cholesterol, FFA, TAG ) ( Accumulation, Dissipation ) in the lysosome due to the loss of function of NPC1 and/or NPC2.

Explanation

Question 4 of 8

2

The highly proliferative nature of cancer cells means they have increased metabolic requirements, especially of which two things?

Select one or more of the following:

Energy
Phospholipids

Explanation

Question 5 of 8

4

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In cancer, metabolism changes.
De Novo Cholesterol ( Synthesis AND uptake, Synthesis, Uptake ) ( Increases, Decreases );
De Novo Lipid ( Synthesis AND uptake, Synthesis, Uptake ) ( Increases, Decreases ).

Explanation

Question 6 of 8

3

Prostate cancer growth is [primarily?] driven by ❌.
It’s a ❌ metabolism cancer and is greatly dependent on ❌.

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Androgens

Non-Warburg

Warburg

Fatty Acid oxidation

Reactive Oxygen Species

Cholesterol oxidation

Explanation

Question 7 of 8

1

CRPC = ??

Select one of the following:

Castration-Resistant Prostate Cancer
Castratian-Resistant Prostate Cancer

Explanation

Question 8 of 8

1

PHSI3012 10-2 Disorders of Lipid Metabolism #2 (T3L2)

PHSI3012 10-2 Disorders of Lipid Metabolism #2 (T3L2)

PHSI3012 10-2 Disorders of Lipid Metabolism #2 (T3L2)

Question 1 of 8

Select from the dropdown lists to complete the text.

Explanation

Question 2 of 8

Select from the dropdown lists to complete the text.

Familial Hypercholesterolaemia is a family of pathologies that range from heterozygous to homozygous. It’s characterised by ( Increased, Decreased ) ( LDL-Chol, HDL-Chol ) levels. Caused by a loss of LDL-R.

Explanation

Question 3 of 8

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Explanation

Question 4 of 8

The highly proliferative nature of cancer cells means they have increased metabolic requirements, especially of which two things?

Select one or more of the following:

Explanation

Question 5 of 8

Select from the dropdown lists to complete the text.

In cancer, metabolism changes.
De Novo Cholesterol ( Synthesis AND uptake, Synthesis, Uptake ) ( Increases, Decreases );
De Novo Lipid ( Synthesis AND uptake, Synthesis, Uptake ) ( Increases, Decreases ).

Explanation

Question 6 of 8

Prostate cancer growth is [primarily?] driven by ❌.
It’s a ❌ metabolism cancer and is greatly dependent on ❌.

Drag and drop to complete the text.

Explanation

Question 7 of 8

CRPC = ??

Select one of the following:

Explanation

Question 8 of 8

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Gene Expression of Steroidogenic Enzymes is ( Increased, Decreased ) in CRPC.

Explanation

	Created by Michael Jardine almost 7 years ago

PHSI3012 10-2 Disorders of Lipid Metabolism #2 (T3L2)

PHSI3012 10-2 Disorders of Lipid Metabolism #2 (T3L2)

PHSI3012 10-2 Disorders of Lipid Metabolism #2 (T3L2)

Question 1 of 8

Select from the dropdown lists to complete the text.

Explanation

Question 2 of 8

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Familial Hypercholesterolaemia is a family of pathologies that range from heterozygous to homozygous. It’s characterised by Increased Decreased( Increased, Decreased ) LDL-Chol HDL-Chol( LDL-Chol, HDL-Chol ) levels. Caused by a loss of LDL-R.

Explanation

Question 3 of 8

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Explanation

Question 4 of 8

The highly proliferative nature of cancer cells means they have increased metabolic requirements, especially of which two things?

Select one or more of the following:

Explanation

Question 5 of 8

Select from the dropdown lists to complete the text.

Explanation

Question 6 of 8

Prostate cancer growth is [primarily?] driven by ❌. It’s a ❌ metabolism cancer and is greatly dependent on ❌.

Drag and drop to complete the text.

Explanation

Question 7 of 8

CRPC = ??

Select one of the following:

Explanation

Question 8 of 8

Select from the dropdown list to complete the text.

Gene Expression of Steroidogenic Enzymes is Increased Decreased( Increased, Decreased ) in CRPC.

Explanation

Familial Hypercholesterolaemia is a family of pathologies that range from heterozygous to homozygous. It’s characterised by ( Increased, Decreased ) ( LDL-Chol, HDL-Chol ) levels. Caused by a loss of LDL-R.

Prostate cancer growth is [primarily?] driven by ❌.
It’s a ❌ metabolism cancer and is greatly dependent on ❌.

Gene Expression of Steroidogenic Enzymes is ( Increased, Decreased ) in CRPC.