Alba Del Rio Serrato
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Quiz on Previous year Quizz 5, created by Alba Del Rio Serrato on 03/12/2017.

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Previous year Quizz 5

Previous year Quizz 5

Question 1 of 19

1

Which of the following answers is correct?

Select one of the following:

  • The NOAEL is defined as the highest dose at which no clinical and/or biological relevant adverse effect is observed in preclinical toxicology studies

  • The NOAEL is defined as the lowest dose at which at least one clinical and/or biological relevant adverse effect is observed in preclinical toxicology studies

Explanation

Question 2 of 19

1

The following are true about the early stages of schizophrenia: (more than one answer might be correct)

Select one or more of the following:

  • Attention deficits may be present

  • Motor dysfunction is an early warning sign.

  • Medical interventions prior to the first psychotic symptoms may be more effective

  • Brain structure that is clearly different from healthy individuals

  • Mild or moderate disturbance in language.

Explanation

Question 3 of 19

1

Schizophrenia is a genetic disorder,

Select one of the following:

  • but it is not heritable

  • and its heritability is around 80%.

  • and environmental factors are not important.

  • and its heritability is around 10%.

  • but genetics factors are not associated with schizophrenia symptoms

Explanation

Question 4 of 19

1

What types of bias affect the "internal validity" of a study? (several answers are correct)

Select one or more of the following:

  • selection bias (creating groups with different confounders; solved by randomization)

  • performance bias and detection bias (investigators respectively treating or assessing more positively those subjects on the treatment arm; controlled by blinding interventions and outcome assessments)

  • attrition bias (dropout of subjects with a negative outcome not included in the final result)

Explanation

Question 5 of 19

1

Which brain function is dominated most by one hemisphere?

Select one of the following:

  • Hearing

  • Smelling

  • Language

  • Memory

  • Vision

Explanation

Question 6 of 19

1

Which of these anatomic structures is not part of the basal ganglia?

Select one of the following:

  • Corpus striatum

  • Red nucleus

  • Subthalamic nucleus

  • Caudate nucleus

Explanation

Question 7 of 19

1

A meta-analysis is a study that

Select one of the following:

  • retrospectively combines all trials performed by one group

  • eliminates the bias introduced by studies of low quality

  • can only be performed when more than 10 trials have been performed

  • is a prospective trial of study quality

  • none of the above

Explanation

Question 8 of 19

1

Which study(ies) belong(s) to Phase I? (more than one answer might be correct

Select one or more of the following:

  • Bioequivalence

  • First in Human

  • Pharmacokinetics in renal impairment

  • Proof of concept

  • Pharmacokinetic drug interaction

Explanation

Question 9 of 19

1

What has the neurotransmitter dopamine been shown to encode?

Select one of the following:

  • stop signals

  • reward signals

  • fear signals

  • motor signals

Explanation

Question 10 of 19

1

Which answer is incorrect? Risk factors for schizophrenia include:

Select one of the following:

  • Weight gain

  • Influenza infection during pregnancy

  • Toxoplasmosis gondii

  • Age of father at conception

  • High expressed emotions families

Explanation

Question 11 of 19

1

What is the main advantage of bipolar electrophysiological recordings, compared to a common reference?

Select one of the following:

  • better spectral resolution

  • better time resolution

  • better spatial resolution

  • higher amplification

Explanation

Question 12 of 19

1

Which of the following statements is correct?

Select one of the following:

  • A SUE is always related to the administration of the test substance

  • A SUSAR can be a serious or a non-serious adverse reaction

  • A SUSAR should be reported to Ethic Committee and Health Authorities

Explanation

Question 13 of 19

1

The attrition (=failure) rate from first in man to registration of a drug in medicine is typically ...

Select one of the following:

  • 50%

  • 90%

  • 20 %

  • 30%

  • E. 99%

Explanation

Question 14 of 19

1

What are the legal preconditions for the conduct of a clinical study? (more than one answer is correct)

Select one or more of the following:

  • IRB approval

  • Insurance Certificate

  • Data protection approval

  • Youth welfare office approval

  • Study bank account

Explanation

Question 15 of 19

1

Which of the following statements is correct?

Select one of the following:

  • The first dose in humans is equivalent to NOAEL

  • The first dose in humans is a fraction of NOAEL

  • The first dose in humans is higher than NOAEL

Explanation

Question 16 of 19

1

Ownership of intellectual property in academic research in Germany and the US is held by

Select one of the following:

  • the inventor(s)

  • the funding agency

  • the University

  • Researcher(s) who are not employed by the University but inventor(s)

  • the University
    Researcher(s) who are not employed by the University but inventor(s)

Explanation

Question 17 of 19

1

Which of the following statements is true regarding the striatum? (more than one answer is correct)

Select one or more of the following:

  • receives inhibitory input from the cortex

  • consists of the lenticular nucleus and the putamen

  • receives dopaminergic input from the substantia nigra pars compacta

  • contains cells that use acetylcholine as their transmitter

  • all of the above statements are true

Explanation

Question 18 of 19

1

Which other description of the clinical symptom chorea is correct?

Select one of the following:

  • Babinski sign

  • akinesia

  • rigidity

  • uncontrollable involuntary movement

  • spasticity

Explanation

Question 19 of 19

1

The primary outcome of a First-in-Human study is always:

Select one of the following:

  • Safety and tolerability

  • Feasibility

  • Pharmacodynamics

  • Therapeutic effect

Explanation

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