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According to the FDA, patients who are opioid-tolerant have been taking opioids for a 1 or longer in the following doses: at least 60mg of oral morphine QD, 25 mcg of transdermal fentanyl per hour, 30 mg oral oxycodone QD, 8 mg hydromorphone QD, 25 mg of oxymorphone QD or an equianalgesic dose of another opioid.