Melanie Grynsztejn
Quiz by , created more than 1 year ago

Quiz on Pharmacogenetics & Genomics, created by Melanie Grynsztejn on 05/12/2017.

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Melanie Grynsztejn
Created by Melanie Grynsztejn almost 7 years ago
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Pharmacogenetics & Genomics

Pharmacogenetics & Genomics

Question 1 of 18

1

Select from the dropdown lists to complete the text.

Pharmacogenetics is study of inherited genetics ( difference, sameness ) in drug ( metabolic, pharmacokinectic ) pathways which can affect ( individual, ethnic group's ) responses to drugs, both in terms of therapeutic effect as well as adverse effects

Explanation

Question 2 of 18

1

Select from the dropdown lists to complete the text.

Nearly ( 90%, 80%, 70% ) of general population have CYP2D6 functional duplication allele
o ( 10%, 20%, 5% ) has inactive copies of CYP2D6 = codeine has no analgesic effect
o ( 2-5%, 5-10%, 10-15% ) ultrarapid metabolizer

Explanation

Question 3 of 18

1

Codeine is metabolized by an enzyme that is genetically regulated called CYP2D6 in the liver that turns codeine into morphine

Select one of the following:

  • True
  • False

Explanation

Question 4 of 18

1

CYP2D6 is responsible for the metabolism of which drugs

Select one or more of the following:

  • Analgesics

  • BB

  • CCB

  • Antidepressants

  • Antispsychotics

Explanation

Question 5 of 18

1

The CYP2C19 metabolizes which drugs

Select one or more of the following:

  • Plavix (clopidogrel)

  • Coumadin (warfarin)

  • Dabigatran (Pradaxa)

  • Apixaban (Eliquis)

Explanation

Question 6 of 18

1

GeneSight Tests for

Select one or more of the following:

  • ADHD

  • Analgesic

  • MTHFR

  • Psychotropic

  • Anticoagulants

Explanation

Question 7 of 18

1

Genotype is

Select one of the following:

  • genetic constitution, alleles present at one locus

  • manifestation of genes

  • phenotypic differences

  • proportion of heterozygous population expressing the phenotype

Explanation

Question 8 of 18

1

Phenotype is:

Select one of the following:

  • genetic constitution, alleles present at one locus

  • manifestation of genotype

  • phenotypic differences in same genotype

  • proportion of heterozygous population expressing the phenotype

Explanation

Question 9 of 18

1

Variable expressivity is

Select one of the following:

  • genetic constitution, alleles present at one locus

  • manifestation of genotype

  • phenotypic differences in same genotype

  • proportion of heterozygous population expressing the phenotype

Explanation

Question 10 of 18

1

Penetrance is

Select one of the following:

  • genetic constitution, alleles present at one locus

  • manifestation of genotype

  • phenotypic differences in same genotype

  • proportion of heterozygous population expressing the phenotype

Explanation

Question 11 of 18

1

Autosomal dominant inheritance

Select one or more of the following:

  • Required one copy of gene mutation to express the associated condition

  • Phenotype is expressed in person heterozygous for a particular allele

  • Requires two copies of gene mutation (one from each parent) to manifest the condition

  • Phenotypes is expressed in person homozygous for a particular allele

Explanation

Question 12 of 18

1

Autosomal recessive:

Select one or more of the following:

  • Requires one copy of gene mutation to express the associated condition

  • Phenotype is expressed in person heterozygous for a particular allele

  • Requires two copies of gene mutation (one from each parent) to manifest the condition

  • Phenotypes is expressed in person homozygous for a particular allele

Explanation

Question 13 of 18

1

Select from the dropdown list to complete the text.

Breast cancer is ( 5 - 10%, 0 - 5%, 10 - 15%, 15 - 20 % ) hereditary

Explanation

Question 14 of 18

1

Which a mutation in which BRCA gene has a 40% lifetime risk for ovarian cancer

Select one of the following:

  • BRCA-1

  • BRCA - 2

Explanation

Question 15 of 18

1

Tamoxifen is metabolized by

Select one of the following:

  • CYP2D6

  • CYP2CI9

Explanation

Question 16 of 18

1

Hereditary nonpolyposis colorectal cancer (HNPCC) or Lynch syndrome is an autosomal dominant genetic condition that has a high risk of colon cancer as well as other cancers including endometrial cancer (second most common), ovary, stomach, small intestine, hepatobiliary tract, upper urinary tract, brain, and skin

Select one of the following:

  • True
  • False

Explanation

Question 17 of 18

1

Amsterdam II criteria for HNPCC/Lynch Syndrome includes 3 relatives with CRC (colorectal cancer) and other HNPCC cancer in the family. Select the HNPCC cancers:

Select one or more of the following:

  • Hepatic

  • Colon

  • Endometrium

  • Small bowen

  • Pancreatic

  • Renal pelvis

Explanation

Question 18 of 18

1

Pharmacogenetics is the study of _________

Select one of the following:

  • germline mutations

  • x-linked mutations

  • autosomal dominant mutations

  • autosomal recessive mutations

Explanation

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