The reaction of antibody with a non soluble antigen or an antigen-cated particles result in formation of visible to the eye clumb is called
agglutination
precipitation
neutralization
complement fixation test
ELlSA makes use of:
fluorenlubels
enzyme
radioactive lubels
It is not a labeled immune for...
widal from used to.....
slide agglutination test
tube agglutination
CUT
lectin pathway
Which of the following immunoglobulins may be transferes to the fetus during pregnancy
lgG
lgM
The genus specific name for group A streptococci is
streptococcus pneumonia
streptococcus viridans
streptococcus diphtheria
streptococcus pyogenes
The main pathogenic factor of corynebacterium diphtheria is
an endotoxin
an exotoxin
a spore
a protein
The specific prophylaxis of diphtheria is performed by
a toxoid
a killed vaccine
passive transfer at serum
a live vaccine
Which of the following statement concerning cholera infection is correct?
death occurs in 46 weeks exclusion and respiratory failure
the disease is marked by microorganism invasion and hemorrhage of large intestine
vibrio cholera produce an acute fehrile disease with
the disease is rapidly progressive and maybe fatal in 2 days because of bacterial multiplication in the gut and shock
Beta lactamase production is a major problem for treatment of infections caused by:
Corynebacterium diphtheria
Neisseria meningitides
Staphylococcus aureus
Treponemapallidum
HIV has been shown to be transmitted by one of the following except
Sexual contact
Perinatal infection
Mosquitos
Blood transfer
Each organism is identified by two names including:
family and kingdom
genus and species
family and species
family and genus
techniques of staining make use of only one dye,where as staining a combination of dyes?
The volutine granules of corynebacterium diptheria are visualized by Staining
The following structure are located in the cytoplasmic membrane?
spore
nucleotid
ribosomes
capsule
Based on their cell wall structure bacteria are divided into:
gram(+) and gram(-)
aerobe and anerobe
sphere and spinal
cocci and rods
Peptidoglycan polymers are found only in:
bacterial cell
animal cell
a,b
viruses
Flagella are present in every bacterium
Sporulation appears to be
an initiation of the bacterium cell
a reaction to conditions that are unfavorable for normal growth
a status to resist desiccation and other harmful conditions
b,c
The complete killing or removal of all microorganisms including bacterial spores is called?
sterilization
disinfection
antisepsis
non is true
Cytoplasm contains:
storage granules
spores
capsules
Which of following component are not found in the gram negative cell wall?
amino acids
lipopolysaccharides
peptidoglycan
teichoic acids
Pfeiffer technique of staining makes use of following dye?
methylene blue
ziehl’s fuchsine
neutral red
gentian violet
Which of the following structure contains genes for enzymes and antibiotic resistance
plasmld
pilli
plasma membrane
Which of the following is the most important structure related to microbial attachment to cells
flagella
plasmid
glycocalix
Which of the following is not a gram negative microbe
Clostridum perfringes
Vibrio cholerae
excheriehia
bordetella
What causes it to be pink
pheiffer's fuchsine
gram iodine
crystale violet
neisser
Selective media are designed to
support the growth of the desires microorganisms
inhibit the growth of non-desired microorganisms
a+b
none of the above
Which part of the antibody molecule reacts with the antigenic determinant agent
the fab fragment
the fe fragment
the constant H region
the constants
The chemical complement pathway is activated by
microbial endotoxins
antigen-antibody complex
microbial proteins
All of the following statement about exotoxins are true expect
they are produce mainly by gram (+) bacteria
they may be neutralized by antitoxins
they are proteins
they are heat stable at 100*
In Solid media bacterial growth is detected by observing
appearance of colonies
development of pellet
development of turbidity
a surface membrane
The last phase of bacterial growth curve is:
log phase
lag phase
stationary phase
phase of decline
Which of the following component is not found in the gram(-) cell wall
lipopolysaccharide
O antigen
The antiseptic is:
an antimicrobial agent that can be used on inanimate object
an antimicrobial agent that can be used on living tissue
an antibiotic
an enzyme
Klett is a staining procedure for visualizing:
volutine granules
All of the following media are differential except:
Teilurite agar
Eosin-methylene blue agar(Levine)
Moller-hiton agar
Deoxycholate citrate
Immunoprophylaxis of tuberculosis includes:
live affenuated vaccine BCG
injection of antimycobacterial serum
passive transfer of ready made antibodies from sensitized person
Passive immunization is an application of:
small doses of infective agent
ready made antibodies, formed by another host in response to artificial immunization or to natural infection
toxoids
killed vaccines
Which of the following statements about exotoxins are true:
they are produced mainly by gram(+) bacteria
Which of the following is not a distinctive characteristic of viruses
viruses lack the machinery for protein synthesis
viruses require living cells for replication
viruses replicate by a process of binary fission
viral genomes are either DNA or RNA but not both
the immune response elicited by Salk’s inactivated polio vaccine is deficient in specific
secretory lgA
serum IgA
serum lgM
IgG
All of the following are characteristics of the human immunodeficiency virus(HIV)expect?
it bind to CD4 molecule preferentially
it contains gp120 and gp30 envelope proteins
it is the causative agent of AIDS
it contains DNA within its core
Complement fixation test requires
dissolved antigen
corpusculum antigen
antitoxin
complement
Which of the immunoglobin molecule is pentamenie
lgD
lgE
lgA
Resection of the transplanted organ due to preformed antibodies in recipient is defined
hyper acute
aclerated
acute
chronic
microorganisms can be defined as living creatures so small that are not visible by eye
Loffler staining procedure stains bacteria in
blue
red
green
yellow
Which of the following is not true related to endotoxins
are secreted from cells
can be linked to meningococcemia
produced by gram negative microorganism
can cause fever
Gram negative bacteria differ from gram(+) organism because they passes?
LPC(A)
Peptidoglycan
Only a cytoplasmic membrane
Lipoteichoic acid
Most bacteria increase in number through the process of
binary fission
budding
sporulation
sexual reproduction
The term “growth” when for microorganism refer to
increase in cell number
production of endospores
the age and size of the cell
all of the above
All of the following statement about bacteria cell division are true except:
all bacteria double their number every 1 hour
bacterial times are influenced by environmental conditions
the two bacterial cells following division are genetically identical, they are ones
all the above
Bacterial nucleotid consist of
no chromosomes
one chromosome
several chromosome
Bacterial capsule can be visual sated by:
gram stain
loeffler stain
klett stain
moller stain
Lipopolysacharides can be found in large amount in:
gram(+) bacterial wall
gram (-) bacterial wall
both
none of above
Complex methods for bacterial staining are
Loeffler stain
Pfefiffer stain
Gram stain
ZiehI-Neelsen stain
Specific identity (serotype) of influenza virus can be accomplished by:
hemmagglutination inhibition test
neutralization test
hemadsorbtion test
enlargement of one or both parotid glands in the common clinical manifestation of:
measles
mumps
rubella
grippe
The initial replication of human poliovirus starts in:
pharyngeal and intestinal mucosa
blood
brain
joint
In congenital rubella the fetus produce:
IgM
The most common classification system used in microbiology is binomal and was established by:
Pasteur
Koch
Linnaeus
Gram
Common pili play role in bacterial;
conjugation
adherence to surface
motility
Endotoxins are:
found in gram (+) bacteria
found in gram(-) bacteria
proteins
a structural component of the spore
Which of the following techniques allows to start with a single piece of microbial DNA and produce billions of copies in matter of hour
PCR
ELlSA
hybridoma biotechnology
IFA
Which of the following is the fastest way to kill endospores
autoclave at 121*C
hot air at 160*C
clorox solution
filtration
Gram positive bacterium is most susceptible to the action of penicillin in the following phase of growth?
lag
log
stationary
decline
The primary immune response include participation of?
The first vaccine was used against:
tuberculosis
hepatitis
small pox
The alternative pathway of complement activation is:
T lymphocytes dependent
antibody independent
antibody dependent
T lymphocytes independent
Which of the immunoglobulins mediates the local immunity
The formation of pharyngeal pseudomembrane is not indicative for
diphtheria
whooping
gas gangrene
The most potent biological toxin known is
clastridiumbotidinum exotoxin
staphylococcus aureus enterotoxin
bacillus cereus toxin
clostridium perfringes exotoxin
The special staining method used for microscopic diagnosis of tuberculosis
Klett
Ziehl-Neelsen
Moller
Cytopathic effect is
killing of bacteria by viruses
absorption of red blood cells by surface of cultured cells
damage of cultured infected cells and associated morphological change
antigen-antibody reaction
Viruses contain the following type of nucleic acid
DNA-single strained
DNA double strained
DNA or RNA
both DNA and RNA
Hepatitis B virus is most often transmitted by
sexual contact
air
blood transfusion
ticks
Varicellazinster virus is a member of
hypersnviridae
hepadnaviridae
retroviridae
paenviridae
Epstizin Bar Virus is the causative agent of:
infectious mononucleosis
Sabin's vaccine against poliomyelitis is secretory immunity in the intestine
monovalent hysosome vaccine
Spherical bacteria,arranged in cluster are known as:
Staphylococci
Streptococci
Diplococci
Vibrios
Which concentration of ethyl alcohol is the most effective one as disinfectant and antiseptic
95%
70%
50%
30%
Penicillin specifically inhibits:
protein synthesis
peptidoglyconsynthesis
nucleic acid synthesis
formation of capsules
Conjugation differs from transformation and transduction in that it requires a contact between the donor and the recipient:
Which of the following structure is involved in bacterial attachment to cell surface?
measurants
Bacterial growth medium that contains penicillins:
minimal medium
selective medium
differential medium
The antigen-antibody complex activates complement through:
classical pathway
alternative pathway
Complement is
an acute phase protein
an extracellular microbial factor
a manose receptor
multicomponent humeral factor trigger enzyme cascade in innate immunity
The unit of measurement of bacterial size is:
nanometer
micrometer
millimeter
kilobase
Bacterial growth curve is generally separated into
two distinct phase
three distinct phase
four distinct phase
five distinct phase
Resistance to many antibiotics is carried by:
R plasmids
sex pilli
Which of the following structures are known to protect bacteria from phago... by white blood cells
Spherical bacteria, arranged in chains are known as:
staphylococci
streptococci
neisseria
bacilli
Endotoxins are associated with
Catalase production
Flagella in gram (-) bacteria
LPS (lipopolyshoccharide)
Capsules in gram (-) bacteria
The antigenic typing of salmonella spp detects:
D, Vi and H antigens
Protein
M protein
Endotoxin
Which of the following test is used to detect delayed type hypersensitivity
ASO test
CFT
Mantoux test
None of the above
Which are the most important immunoglobulins at the mucosal surfaces
IgA
Salmonella spp is causative agent of
typhoid fever
cholera
paratyphoid fever
bacterial dysentery
There are animal reservoirs for:
leptosspinosis
salmonellosis
Bacteria could be cultured in artificial nutrient media
The mean doubling time for most bacterium is
8 hours
24 hours
20-30 minutes
4 weeks
Dark field microscopy is usually applied for
stained preperations with irreversion cell between cochser
unstrained wet preparation with oil between the conduncer and the slide irreverSion
unstained wet properations with water between the condenser and the slide
ultra thin reactions of tissue
Which of the following component contain peptidoglycan?
Gram(+) cell walls +F
DNA
Flagella
Cytoplasmic membrane
The clorax solution and ethyl alcohol are example of:
sterilizing agents
antibiotics
base analogs
Which immunoglobin contain j chain
IgA and lgG
lgM and lgA
lgG and IgM
lgD and lgG
Which of the following are DNA viruses?
adenoviruses
picornviruses
paramyxoviruses
orthomyoviruses
Which one is considered a vireal disease viral
herpes simplex type 1
herpes simplex type 2
rubella vire
medual vire
Which of the following diagnostic markers persist in the blood stream of HBV infected individuals and is found an (imcatox) of infection
HBsAg
anti-HAV antibodies
H-2
All of the following statement about poliomyelitis are correct except:
virus is transmitted mainly in respiratory droplets
most disease occur apparent sub-clinical infection
persistantviremiafam CNS involvement
spinal poliomyelitis involves the anterior born cells of the spinal cord
During the incubation period of the HBV infection which of the following viral diagnostic marker is most abundant in blood and is commonly used for diagnosis
HBSAg
Anti-HAV antibodies
Anti-HCV antibodies
Influenza virus on RNA virus:
Human herpes virus 2 is usually associated with:
genital herpes
rubelia
erpes zoster
Human immunodeficiency virus belongs to:
adenoviridae
togruviridae
poxviridae
The presence of low levels lgG but not lgM antibodies to rubella virus in the newborn suggests:
congenital infection
autoimmune disease
presence of maternal antibodies
allergy
A four fold or greater increase in autoantibody titer,measured by appropriate available viral diagnostic test and performed on serum collected at time of disease onset and 14 days later would:
be highly suggestive to the presence of the disease
indicate previous infection in healthy person
not be sufficient for diagnosis
not be informative since the serum specimens were not collected at proper interval of time
Current acute HAV infection is best diagnosed by the presence of?
HBgcAg
anti-HBcsntibodies
IgM anti-HAV
delta antigen
Which of the following microorganisms lack a cell wall
ram positive cocci
gram negative rods
richetsia
mycoplasma
All of the following statement are characteristics for group A strepcoccus?
they are rarely resistaned to paraisitis
they produce beta-hemolysis on blood agar
they are sensitive to bacitracin
they are of the normal environment fiera
Herpes virus varicella is a member of (zoster) (varicella zoster virus is member of:
herpes viridae
Which of the following Viruses cause infection mononucleosis?
Herpes simplex 1
Epstein-barr-viruses
CMV
Varicella zoster virus
Type 2 hypersensitivity reactions are
anaphylactic and atopic
comlement-mediated cytolysis
immune-complexes mediated
cell mediated with participation
The causative agent of AIDS is:
Human herpes virus
Haemophilus influenzae
Human papilloma virus
HIV
Which of the following components contain peptidoglycan?
Gram (+) cell walls
Gram (-) cell walls
Risus sardonicus refers to:
tetanus
botulism
Slide agglutination test detects:
microbial antigens
unknown
viral particles
bacterial phagocytosis
Protein A is a surface protein covalently bound to most strains of
staphylococcus aureus
staphylococcus epidermidis
Which of the following interferons participate in the .... immune response?
interferon alpha
interferon beta
interferon gamma
The microbiological test that is widely used for the diagnosis of staphylococcal
Agglutination test type wide
Agglutination type ....oneresh
ASO
Which of the following statements are characteristics for group A streptococci
they are rarely resistant to penicillin
they produce Beta-hemolysis on blood agar
they are part of the normal intestinal flora
Which of the following vaccines is of routine use?
against smallpox
against hepatitis
against measles
against mumps
Which of the following vaccines is not of routine use anymore
against hepatitis B
)against mumps (not* hangislkfarkliysacvpodur)
Which are is consider venereal disease virus
herpes simplex 2
The subspecies group are identified on the basis of
arrangement of the bacteria on the preparations
their antigen
gram staining
their growth requirement
The main pathogenic factor of clostridium tetani is
endotoxin
exotoxin
RIA makes use of:
fluorescence labels
enzymes
radioactive labels
it is not labelled immune reaction
Which of the following immunoglobulin is the principal immunoglobin in exocrine secretion?
IgE
The causative agents of tetanus is:
clostridium difficile
clostridium botulinum
clostridium perfingens
clostridium tetani
The positive coagulase test for staphylococcus aureus is indicated by:
character of plasma
clotting of plasma
formation of red ring
beta hemolysis on blood agar
This microorganism causes a sexually transmitted disease that can be diagnosed by demonstration of cytoplasmic inclusions in......?
Chlamydia atrachomatis
Candida albicans
Trepomena pfedure
Neisseria gonorrhoeae
Viridans streptococci:
can cause neonatal sepsis
are involved in urinary infection in females
are the most frequent cause of bacterial endocarditis
cause zoonotic disease transmitted to humans primary by contact with animal urine
Which of the following statement about microbiological diagnosis of diphtheria is correct
Microorganisms are coagulase positive
microscopy from culture on lofller’s medium or tallarite agar would reveal characteristic chinede letter formation
microorganisms are impossible to be identified by Neisser stain because of their small size
microorganisms are delicate and can be cultured only in ell culture
Exotoxins play a determinant role in the pathogenesis of each of the following EXCEPT:
plaque
Influenza virus belongs to:
hepado viridae
orthomyxoviridae
paramyxoviridae
hypesviridae
Which of the following is the leading cause of post transfusion hepatitis producing the highest frequency of chronic disease
hepatitis A virus (HAV)
hepatitls B virus (HBV)
hepatitis C virus (HCV)
hepatitis D
Which of the following immunoglobulins has the highest serum level in healthy adults
IgD
Trepanemapallidum is the causative agent of:
plague
syphilis
The pathogenesis and clinical of primary tuberculosis are characterized by
cell mediated response with macrophage and lymphocyte infiltrating the focus of infection
a complement mediated immune response
a humoral mediated immune response
an absence of adaptive immune response
Which form of plague is most likely to be transmitted from human to human:
typhoidal
sylvatic
pneumonic
ulceroglandular
Staphylococci differ from streptococci in:
gram reactivity
cell diameter
acid fast staining
catalase production
All of the following characteristics of Salmonella typhimurium are true EXCEPT:
has a multianimal reservoir
is one of the most common causes of enterocolitis
ferments lactose
is a gram (-), molite, endotoxin bearing rod
Which of the following characteristics concerning influenza A virus is correct
it can always cause generalized infections
it can always cause encephalitis
it has the capacity to undergo shift and drift
it has nonsegmented negative sense genoma
Hepatitis A virus is most often transmitter by
contaminated food
shared needles
All of the following statements are characteristic for group A streptococci EXCEPT:
they are rarely resistant to Penicillin