Alannah McDonnell
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biochem Quiz on Biochem lect 7 - free radicals and the human body, created by Alannah McDonnell on 05/03/2018.

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Alannah McDonnell
Created by Alannah McDonnell almost 7 years ago
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Biochem lect 7 - free radicals and the human body

Question 1 of 16

1

Oxygen can be toxic

Select one of the following:

  • True
  • False

Explanation

Question 2 of 16

1

Which of theses are reasons that oxygen is essential?

Select one or more of the following:

  • Oxidation reactions

  • Generation of ATP (oxidative phosphorylation)

  • Detoxification reactions

  • Anaerobic glycolysis

  • Bio synthetic reactions

Explanation

Question 3 of 16

1

Why is oxygen classified as toxic?

Select one of the following:

  • When it accepts single electrons it is transformed into highly reactive oxygen radicals than can damage things.

  • When it accepts double electrons it is transformed into highly reactive oxygen radicals than can damage things.

  • When it accepts single electrons it is transformed into non-reactive oxygen radicals than can damage things.

  • It takes part in unnecessary reactions

Explanation

Question 4 of 16

1

What do oxygen radicals damage?

Select one or more of the following:

  • Cellular lipids

  • Proteins

  • DNA

  • Glucose

  • Starch

Explanation

Question 5 of 16

1

What are the major sources of primary ROS in the cell?

Select one or more of the following:

  • CoQ generates superoxide in ETC

  • Respiration in lungs

  • Oxidase, oxygenates and peroxidases

  • Ionizing radiation

  • Non-ionizing radiation

Explanation

Question 6 of 16

1

Where can evidence of free radical damage be seen?

Select one of the following:

  • >100 disease states

  • <100 disease states

  • >1000 disease states

Explanation

Question 7 of 16

1

Where is evidence of free radical damage in disease states described?

Select one or more of the following:

  • As primary cause of the disease

  • By enhancing complications

  • In the lumen of cells

Explanation

Question 8 of 16

1

Superoxide and the hydroxyl radical Initiate lipid peroxidation in..

Select one or more of the following:

  • Cellular membrane

  • Mitochondrial membrane

  • Nuclear membrane

  • ER membrane

Explanation

Question 9 of 16

1

Increase in membrane permeability due to radical-mediated damage leads to..

Select one of the following:

  • A further influx of ca2+

  • Repair of the mtiochondria

  • Ca2+ leaving the cell

  • Further escaping of radicals

Explanation

Question 10 of 16

1

Oxidation of nuclear and mitochondrial DNA results in ...

Select one or more of the following:

  • Strand breaks

  • Various damages

  • RNOS

  • Influx of Ca2+

Explanation

Question 11 of 16

1

Disruption of the mitochondrial membrane may augment free radical damage

Select one of the following:

  • True
  • False

Explanation

Question 12 of 16

1

Oxygen derived free radicals are a minor source of DNA damage

Select one of the following:

  • True
  • False

Explanation

Question 13 of 16

1

The non-specific binding of Fe2+ to DNA...

Select one or more of the following:

  • facilitates localized production of the hydroxyl radical

  • Can attack the deoxyribose backbone

  • Can cause strand breaks

  • Will cause apoptosis

  • Can be protective

Explanation

Question 14 of 16

1

At high concentrations nitrogen combines with oxygen or superoxide to form reactive and toxic species which contain both N and O.

Select one of the following:

  • True
  • False

Explanation

Question 15 of 16

1

RNOS’s are implicated in ...

Select one or more of the following:

  • Neurodegenerative diseases

  • Chronic inflammatory diseases

  • Hay fever

  • Alcoholism

  • Hunger

Explanation

Question 16 of 16

1

What are some of the consequences of high concentrations of NO during inflammation?

Select one or more of the following:

  • Inhibition of enzymes

  • Mitochondrial lipid peroxidation

  • Inhibition of ETC and energy depletion

  • Single or double strand breaks in DNA

  • Modification of bases in DNA

Explanation

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