Crystal Yu
Quiz by , created more than 1 year ago

•Be able to describe drug delivery to the above-mentioned areas •Be able to describe the different types of suppository bases and their properties •Know and describe three methods to compound suppositories •Be able to manufacture suppositories with the different types of bases (after the lab) •Determine the density factor of a drug in different bases and be able to use the appropriate calculations for suppositories

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Crystal Yu
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Suppositories

Suppositories

Question 1 of 31

1

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The mucosal route of drug administration is divided into seven membrane surfaces
characterized as , , , ,
, vaginal, and rectal.

Explanation

Question 2 of 31

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Suppositories are sometimes preferred because it evades the that happens in the liver

Explanation

Question 3 of 31

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Vaginal inserts are often compounded with -soluble bases such as to minimize leakage

Explanation

Question 4 of 31

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Rectal suppositories are or . Approximately 2 g and are about 2 to 3 cm long

Explanation

Question 5 of 31

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Vaginal inserts are or shaped. The weigh about to g

Explanation

Question 6 of 31

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Urethral inserts vary depending on whether it is for male or female.
Males - They are in diameter, in length, and in weight
Females - They are in diameter, in length, and in weight

Explanation

Question 7 of 31

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The choice of a particular melting range is dictated by the influence of other components that influence the final melting range of the product. In general, suppository bases melt between and degrees

Explanation

Question 8 of 31

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Hard fat suppository bases are mixtures of of longer-chain fatty acids.

Explanation

Question 9 of 31

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bases are mixtures of hydrophilic materials that in combination are solid at room temperature and yet release the drug by melting, erosion, and dissolution when administered to the patient

Explanation

Question 10 of 31

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drugs are treated as different drugs because they display different properties. An example is which should not be heated over degrees.

Explanation

Question 11 of 31

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Cocoa butter has no , and therefore, cannot emulsify water. Some substances such as chloral hydrate tend to lower the melting point of CB. It may be necessary to add to raise the melting point.

Explanation

Question 12 of 31

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Water-soluble ionized salt forms of drugs that have base partition coefficients should be used when possible with cocoa butter particularly when a is desired.

Explanation

Question 13 of 31

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Newer synthetic triglycerides such as and have properties, do not exhibit like cocoa butter. However, they are more expensive

Explanation

Question 14 of 31

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is a useful suppository base for vaginal inserts. Used for sustained release over a long period

Explanation

Question 15 of 31

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is categorized in the NF as a , plasticizer, solvent and tonicity-adjusting agent

Explanation

Question 16 of 31

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For suppositories in the body, there is either melting or erosion (dissolution). The erosion may be favorable for those who want

Explanation

Question 17 of 31

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PEG bases are incompatible with a large number of drugs, especially those prone to . PEG also interacts with some plastics such as which is used in some prescription vials, which is why suppositories are wrapped in foil or in plastic bags

Explanation

Question 18 of 31

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Several surfactants closely related chemically to polyethylene glycols can be used as suppository vehicles. Examples of these are polyoxyethylene and

Explanation

Question 19 of 31

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One major advantage of substances such as polyoxyethylene sorbitan fatty acid esters and polyoxyethylene stearates as suppository vehicles is their

Explanation

Question 20 of 31

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Cocoa butter melts quickly at body temperature and is with body fluids. This the diffusion of fat-soluble drugs to the affected sites.

Explanation

Question 21 of 31

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is a suitable base for some antiseptics

Explanation

Question 22 of 31

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Glycerinated gelatin is seldom used rectally because of its

Explanation

Question 23 of 31

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When selecting a suppository base, fatty bases exhibit the following:

Select one or more of the following:

  • More comfortable, non-irritating

  • Stinging sensation, defecating reflex

  • Less reactive, melt on storage

  • More reactive, doesn't melt on storage

  • Rectal administration

  • Vaginal administration

  • Poor release of hydrophobic drugs systemically

  • More reliable release of hydrophobic drugs systemically

  • Emollient effect locally

Explanation

Question 24 of 31

1

When selecting a suppository base, PEG exhibits the following:

Select one or more of the following:

  • More comfortable, non-irritating

  • Stinging sensation, defacating reflex

  • Less reactive, melt on storage

  • More reactive, doesn't melt on storage

  • Rectal administration

  • Vaginal administration

  • Poor release of hydrophobic drugs systemically

  • More reliable release of hydrophobic drugs systemically

  • Emollient effect locally

Explanation

Question 25 of 31

1

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:
- Plastic-like mass is prepared by triturating grated cocoa butter and active ingredients in a mortar
- The mass is formed into a ball in the palm of the hands then rolled into a uniform
- The cylinder is then cut into a number of pieces which are rolled to produce a shape

Explanation

Question 26 of 31

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Advantages to Hand Rolling are the following:

Select one or more of the following:

  • Don’t require special equipments

  • Avoid necessity of heating cocoa butter

  • Have an elegant and professional appearance

  • Density calculations and mold calibration are required

  • Require experience and good technique

Explanation

Question 27 of 31

1

Disadvantages of Hand Rolling are the following:

Select one or more of the following:

  • Require experience and good technique

  • Don’t have elegant appearance

  • Caution must be used when heating the base and drug

  • Density calculations and mold calibration are required

  • Mixed mass of suppository base and the drug is forced into a special compression molds

Explanation

Question 28 of 31

1

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:
- First, melt the suppository base
- Dispersing the drug in the melted base
- Remove from the heat and pour into a supp. mold
- After , the suppositories are removed from the mold
- Metal molds must be !!

Explanation

Question 29 of 31

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:
Mixed mass of suppository base and the drug is forced into a special compression molds

Explanation

Question 30 of 31

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Density factor = Weight of / Weight of

Explanation

Question 31 of 31

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When DF is unknown, you can determine is via double casting method:
- Take -% of base and pour all the drug you need into the mold
- And then take the rest of the base () and fill it to the top
- Allow it to cool down
- Cut off excess base
- Take suppositories out, re-melt and pour again
- Calculating for excess is important because the base will

Explanation

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