Immunology Exam 2 Prep

Question 1 of 58

1

Functions of primary lymphoid organs

Select one or more of the following:

site of B and T lymphocyte development and education
provide a collection of T and B lymphocytes with receptors specific for diverse antigens for secondary lymphoid tissue
production/differentiation of dendritic cells from progenitor cells
central tolerance (render T and B cells tolerant to self antigens)

Explanation

Question 2 of 58

1

Which are primary lymphoid organs

Select one or more of the following:

Thymus (T-cells)
Ileal Peyer's Patches (B - cells)
Bursa (b-cells)
Bone Marrow
tonsil/spleen
Lymph and hemal nodes
Jejunal Peyer's patch

Explanation

Question 3 of 58

1

Which are secondary Lymph Tissues

Select one or more of the following:

Bursa (B-cells)
Tonsil/spleen
Jejunal Peyer's Patch
Bone Marrow
Thymus (T-cells)
Lymph and Hemal nodes

Explanation

Question 4 of 58

1

Fill the blank spaces to complete the text.

Lymphoblasts invade the from the bone marrow where they become . These cells then mature to become .

Explanation

Question 5 of 58

1

There is a difference between immature and naive T-cells.

Select one of the following:

True
False

Explanation

Question 6 of 58

1

Fill the blank space to complete the text.

Immature t-lymphocytes are called .

Explanation

Question 7 of 58

1

Recognition of a self-major histocompatibility complex (MHC) molecule is ❌ selection.
Elimination of a cell with high affinity for self peptides is ❌ selection.
Death by neglect of cells that so not recognize their MHC is negative selection.

Drag and drop to complete the text.

positive

negative

Explanation

Question 8 of 58

1

Expression of accessory molecules during thymocyte maturation
1) signaling component of T-cell receptor - ❌
2) T-helper cells - ❌
3) Cytotoxic T cells - ❌

Drag and drop to complete the text.

CD3

CD4

CD8

Explanation

Question 9 of 58

1

Label this image

Drag an answer into the correct orange point.

T-cell receptor

Polymorphic residue of MHC molecule

MHC

self peptide

anchor residue of peptide

"pocket" of MHC molecule

T cell contact residue of peptide

thymocyte or T-lymphocyte

thymic epithelial cell or dendritic cell

Explanation

Question 10 of 58

1

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cortical epithelial cells

medullary epithelial cells

dendritic cell

MHC bearing

Explanation

Question 11 of 58

1

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immature (1)

Immature (2)

mature

cortical epithelial cells

positive

MHC

dendritic

negative

self-tolerance

Explanation

Question 12 of 58

1

Fill the blank spaces to complete the text.

MHC class 1 binding leads to mature T cell
MHC class 2 binding leads to mature T cell

Explanation

Question 13 of 58

1

Single-positive thymocytes leave the thymus as a single memory cell and are very important for viral immunity. (they are also more prevalent in pigs)

Select one of the following:

True
False

Explanation

Question 14 of 58

1

AIRE gene encodes for..

Select one or more of the following:

self peptides
insulin
thyroid hormone
collagen
T-cell receptors
B-cell receptors

Explanation

Question 15 of 58

1

Fill the blank spaces to complete the text.

() control expression of over 400 tissue specific proteins.
They are expressed by cells with MHC molecules.
genes are important for developing to become .

Explanation

Question 16 of 58

1

❌ - zinc containing peptide produced by thymic epithelial cells important for T- cell function.
❌ - regulate positive selection (produced from Hassall's corpuscles)

Drag and drop to complete the text.

Thymulin

Thymic stromal lymphopoietin

Explanation

Question 17 of 58

1

Zinc is not essential for T cells and skin enzymes.

Select one of the following:

True
False

Explanation

Question 18 of 58

1

Which are consequences of not having a thymus (mice and cats)

Select one or more of the following:

no T cells in secondary lymphoid tissue
No t cells in primary lymphoid tissue
no T cells in circulation
defective rejection of graft tissue
intact rejection of graft tissue
defective t cell mediated immunity
antibodies to protein antigen decreased, other antibodies are okay

Explanation

Question 19 of 58

1

Which of the following processes is preserved in nude mice or nude cats

Select one of the following:

graft tissue rejection
t cell immunity
circulating antibody levels
B lymphocyte concentrations
CD4 and CD8 lymphocyte concentration

Explanation

Question 20 of 58

1

Thymecotmy at birth in calves has little effect on T cell immunity compared to rodents because the thymus is fully developed at birth.

Select one of the following:

True
False

Explanation

Question 21 of 58

1

Where are B cells developed mainly for primates and rodents.

Select one of the following:

Bone Marrow
ileal peyer's patches
bursa
appendix

Explanation

Question 22 of 58

1

When is the Peyer's patch in the ileum involuted by

Select one of the following:

12 mo
11 mo
at birth
15 mo

Explanation

Question 23 of 58

1

When is the discontinuous jejunal peyer's patch involuted by?

Select one of the following:

15 mo
at birth
it isn't - it is life long
11 mo

Explanation

Question 24 of 58

1

What is the role of the bursa

Select one of the following:

generate BcR diversity
MHC expression
positive selection

Explanation

Question 25 of 58

1

What occurs within the cortex of the Bursa

Select one of the following:

stromal cells present self-antigens on surface receptors to B cells
negative selection of self reactive B cells
B cell proliferation and rearrangement of genes occurs

Explanation

Question 26 of 58

1

Fill the blank spaces to complete the text.

In the of the bursa, stromal cells present on the surface receptors (sIgM) to B cells. selection occurs when B cells are .

Explanation

Question 27 of 58

1

Effects of bursectomy or removal of ileal peyer's patch

Select one or more of the following:

total lymphocyte pool would slightly decrease
humoral immunity (antibody concentration markedly altered)
there would be no circulating T-lymphocytes
dendritic cells in tissues would decrease

Explanation

Question 28 of 58

1

Lymphocyte cones each have the same specificity for epitopes because there is not diverse set of genes.

Select one of the following:

True
False

Explanation

Question 29 of 58

1

What is gene rearrangement in primary or central organs unique to?

Select one or more of the following:

innate immune system
adaptive immune system
vertebrates
invertebrate

Explanation

Question 30 of 58

1

the insertion of upstream DNA or the addition of gene rearrangement (occurs in the bursa or its species equivalent -ileal peyer's patch-)

Select one of the following:

gene interconversion
gene mutation
gene conversion
gene morphing

Explanation

Question 31 of 58

1

Fill the blank spaces to complete the text.

Somatic hypermutation only happens to . It is a mutation that occurs in the centers during exposure.

Explanation

Question 32 of 58

1

Fill the blank spaces to complete the text.

What do each of the letters stand for when it comes to receptor chain regions (gene segments)
V-
D-
J-
c-

Explanation

Question 33 of 58

1

B cell receptor chains
❌ - VJC
❌ - VDJC

T-cell receptors chain pairs
Gamma and Delta
❌ - VJC
❌- VDJC
Alpha and Beta
❌- VJC
❌ - VDJC

Drag and drop to complete the text.

light

heavy

Gamma

delta

Alpha

Beta

Explanation

Question 34 of 58

1

When does receptor gene rearrangement occur in each lymphocyte?

Select one of the following:

during the mutation process
during the selection process
during the migration process
after each lymphocyte leaves and enters circulation

Explanation

Question 35 of 58

1

Receptor gene rearrangement is a random process (like shuffling cards).

Select one of the following:

True
False

Explanation

Question 36 of 58

1

Fill the blank spaces to complete the text.

RAG or 1 and 2, is a gene that initiates recombination.

Explanation

Question 37 of 58

1

Which of the following are members of the nonhomologous end joining (NHEJ) pathway of DNA repair?

Select one or more of the following:

RAG 1
TdT polymerase
Artemis
DNA dependent protein kinase, catalytic subunit (DNA-PKcs)

Explanation

Question 38 of 58

1

Which B cell chain rearranges first? (heavy or light)

Select one of the following:

heavy
light

Explanation

Question 39 of 58

1

The B cell gets a few tries to rearrange its heavy chain.

Select one of the following:

True
False

Explanation

Question 40 of 58

1

Which gene loops out a segment of DNA to be broken from the main segment for use in recombination?

Select one of the following:

RAG
TdT
Artemis

Explanation

Question 41 of 58

1

Fill the blank spaces to complete the text.

RAG knows where to cut because the gene sequence has flanked by the gene segments.

Explanation

Question 42 of 58

1

❌ base pairs make about ❌ turn of the DNA helix.
❌ base pairs make about ❌ turns of the DNA helix.

Drag and drop to complete the text.

12

1

23

2

Explanation

Question 43 of 58

1

Fill the blank spaces to complete the text.

The region begin targeted by RAG is flanked first by the conserved region, then comes the region (which is removed for the ), and finally the conserve region.

Explanation

Question 44 of 58

1

❌: movement of a cell in response to a chemical stimuli
❌: a family of cytokines with the ability to induce direct chemotaxis
❌: transmembrane cell adhesion proteins and signaling receptors (ex CD11b/CD18)

Drag and drop to complete the text.

chemotaxis

chemokine

integrins

Explanation

Question 45 of 58

1

Fill the blank spaces to complete the text.

CCR7 is the cell receptor that interacts with the chemokine receptor for chemokines CCL and CCL which are both crucial for T-cell trafficking.

Explanation

Question 46 of 58

1

Fill the blank spaces to complete the text.

CXCR5 is a cell receptor that interacts with the chemokine CXCL to traffic B cells.

Explanation

Question 47 of 58

1

❌ cells take up bacterial ❌ in the skin (at the site of infiltration) and then move to enter a draining lymphatic vessels using ❌ to migrate. Antigen bearing dendritic cells enter the draining lymph nodes, where they settle in the ❌ areas.

Drag and drop to complete the text.

Dendritic

antigens

chemokines

T-cell

Explanation

Question 48 of 58

1

Where do CCR7 naive and memory T-cells migrate.

Select one of the following:

LN follicle
Cortex
Paracortex

Explanation

Question 49 of 58

1

Where do CXCR5 presenting B-cells migrate?

Select one of the following:

paracortex
cortex
LN follicle

Explanation

Question 50 of 58

1

Where do CCR7 presenting dendritic cells migrate.

Select one of the following:

paracortex
LN follicle
cortex

Explanation

Question 51 of 58

1

Which chemokines do dendritic cells use to migrate through tissues (3)

Select one or more of the following:

CCL19
CCL21
CXCL13
CXCL12

Explanation

Question 52 of 58

1

Hemolymph nodes contain B cells in cortex and T-cells at the center. They also have gamma/delta T cells.

Select one of the following:

True
False

Explanation

Question 53 of 58

1

function of splenic red pulp

Select one or more of the following:

filters blood
filters lymph
removes aged blood cells and immune complex coated cells by macrophages in sinus the red pulp
salvage iron and bilirubin from red blood cells

Explanation

Question 54 of 58

1

Functions of splenic white pulp

Select one or more of the following:

marginal zones - macrophage APC
follicles - B lymphocytes reside
periarteriolar sheath (PALS) - t cells
no high endothelial venules

Explanation

Question 55 of 58

1

Select from the dropdown lists to complete the text.

The ( sinusoidal, nonsinusoidal ) type of spleen has an abundance of venous sinuses which store large amounts of blood for quick release. It common in horses, dogs, and humans.
The ( nonsinusoidal, sinusoidal ) type of spleen has poorly developed sinuses. It is most prominent in cats and ruminants.

Explanation

Question 56 of 58

1

The spleen does not contract and the smooth muscle located around the ellipsoid capillary is used to control in and out flow.

Select one of the following:

True
False

Explanation

Question 57 of 58

1

Bone marrow can act as a secondary lymphoid organ by memory cell colonization, and a release of large quantities of antibodies in rodents and other species when a large dose of antigen is encountered.

Select one of the following:

True
False

Explanation

Question 58 of 58

1

label this image

Drag an answer into the correct orange point.

pluripotent stem cell

common lymphoid

NK

T

B

myeloid

megakaryocyte / erythroid

eruthrocytes

Platelets

megakaryocyte

granulocyte / macrophage

monocyte

neutrophil

eosinophil

basophil

	Created by Sarai Gruver over 6 years ago

Primary Lymphoid tissue (section 7) - Immunobiology to tumors (section 13)

Immunology Exam 2 Prep

Question 1 of 58

Functions of primary lymphoid organs

Select one or more of the following:

Explanation

Question 2 of 58

Which are primary lymphoid organs

Select one or more of the following:

Explanation

Question 3 of 58

Which are secondary Lymph Tissues

Select one or more of the following:

Explanation

Question 4 of 58

Fill the blank spaces to complete the text.

Lymphoblasts invade the from the bone marrow where they become . These cells then mature to become .

Explanation

Question 5 of 58

There is a difference between immature and naive T-cells.

Select one of the following:

Explanation

Question 6 of 58

Fill the blank space to complete the text.

Immature t-lymphocytes are called .

Explanation

Question 7 of 58

Recognition of a self-major histocompatibility complex (MHC) molecule is ❌ selection. Elimination of a cell with high affinity for self peptides is ❌ selection. Death by neglect of cells that so not recognize their MHC is negative selection.

Drag and drop to complete the text.

Explanation

Question 8 of 58

Expression of accessory molecules during thymocyte maturation 1) signaling component of T-cell receptor - ❌ 2) T-helper cells - ❌ 3) Cytotoxic T cells - ❌

Drag and drop to complete the text.

Explanation

Question 9 of 58

Label this image

Drag an answer into the correct orange point.

Explanation

Question 10 of 58

Label this image

Drag an answer into the correct orange point.

Explanation

Question 11 of 58

Label this image

Drag an answer into the correct orange point.

Explanation

Question 12 of 58

Fill the blank spaces to complete the text.

MHC class 1 binding leads to mature T cell MHC class 2 binding leads to mature T cell

Explanation

Question 13 of 58

Single-positive thymocytes leave the thymus as a single memory cell and are very important for viral immunity. (they are also more prevalent in pigs)

Select one of the following:

Explanation

Question 14 of 58

AIRE gene encodes for..

Select one or more of the following:

Explanation

Question 15 of 58

Fill the blank spaces to complete the text.

() control expression of over 400 tissue specific proteins. They are expressed by cells with MHC molecules. genes are important for developing to become .

Explanation

Question 16 of 58

❌ - zinc containing peptide produced by thymic epithelial cells important for T- cell function. ❌ - regulate positive selection (produced from Hassall's corpuscles)

Drag and drop to complete the text.

Explanation

Question 17 of 58

Zinc is not essential for T cells and skin enzymes.

Select one of the following:

Explanation

Question 18 of 58

Which are consequences of not having a thymus (mice and cats)

Select one or more of the following:

Explanation

Question 19 of 58

Which of the following processes is preserved in nude mice or nude cats

Select one of the following:

Explanation

Question 20 of 58

Thymecotmy at birth in calves has little effect on T cell immunity compared to rodents because the thymus is fully developed at birth.

Recognition of a self-major histocompatibility complex (MHC) molecule is ❌ selection.
Elimination of a cell with high affinity for self peptides is ❌ selection.
Death by neglect of cells that so not recognize their MHC is negative selection.

Expression of accessory molecules during thymocyte maturation
1) signaling component of T-cell receptor - ❌
2) T-helper cells - ❌
3) Cytotoxic T cells - ❌

MHC class 1 binding leads to mature T cell
MHC class 2 binding leads to mature T cell

() control expression of over 400 tissue specific proteins.
They are expressed by cells with MHC molecules.
genes are important for developing to become .

❌ - zinc containing peptide produced by thymic epithelial cells important for T- cell function.
❌ - regulate positive selection (produced from Hassall's corpuscles)

What do each of the letters stand for when it comes to receptor chain regions (gene segments)
V-
D-
J-
c-

B cell receptor chains
❌ - VJC
❌ - VDJC

T-cell receptors chain pairs
Gamma and Delta
❌ - VJC
❌- VDJC
Alpha and Beta
❌- VJC
❌ - VDJC