Lecture 3 - GFR

Question 1 of 35

1

What is normal GFR in adult humans?

Select one of the following:

100-125 ml/min
4500-6000 ml/min
1 - 2 ml/min
540 - 900 ml / min

Explanation

Question 2 of 35

1

What does glomerular ultra-filtrate consist of?

Select one or more of the following:

water
small solutes
large solutes
plasma
urine

Explanation

Question 3 of 35

1

Glomerular Ultrafiltrate is normally ...

Select one of the following:

containing proteins
protein free

Explanation

Question 4 of 35

1

What does Regulated reabsorption of water and solutes allow for?

Select one or more of the following:

regulation of extracellular fluid volume
regulation of osmolality
regulation of acid base balance
homeostasis of whole body phosphate concentrations
homeostasis of whole body calcium concentrations
homeostasis of whole body potassium concentrations

Explanation

Question 5 of 35

1

Which of these are freely filtered but not reabsorbed?

Select one or more of the following:

urea
creatinine
water
salt
proteins

Explanation

Question 6 of 35

1

Permselectivity = the restriction of the ❌ of ❌ across ❌ on the basis of ❌ size, charge, and physical ❌

Drag and drop to complete the text.

permeation

permeability

macromolecules

micromolecules

the glomerular barrier

bowmans space

molecular

atomic

configuration.

conglobulation.

Explanation

Question 7 of 35

1

Podocytes = ❌, highly ❌ cells which line the ❌ of glomerular ❌ and thus face the ❌ and the primary ❌

Drag and drop to complete the text.

specialized

common

differentiated

similar

outside

inside

capillaries

vessels

Bowman's space

glomerulus

urine

urea

Explanation

Question 8 of 35

1

Podocytes have a ____ cell body

Select one of the following:

large
small
average sized

Explanation

Question 9 of 35

1

The diaphragm in the podocyte covers the...

Select one of the following:

filtration slit
fenestration
foot process
whole cell body

Explanation

Question 10 of 35

1

What type of collagen composes the backbone of the fibrous network in the glomerular basement membrane?

Select one of the following:

type 1 collagen
type 2 collagen
type 3 collagen
type 4 collagen

Explanation

Question 11 of 35

1

What is the normal urine flow rate in adult humans?

Select one of the following:

1 - 2 ml/min
100-125ml/min
540-900 ml/min
900-1500ml/min

Explanation

Question 12 of 35

1

What is the normal renal blood flow rate in adult humans?

Select one of the following:

900-1500 ml/min
4500 - 6000 ml/min
540-900 ml/min
1-2 ml/min

Explanation

Question 13 of 35

1

What is the normal renal plasma flow rate in adult humans?

Select one of the following:

540-900 ml/min
4500-6000 ml/min
900 - 1500 ml/min
1-2ml/min

Explanation

Question 14 of 35

1

what does the filtration fraction generally measure?

Select one of the following:

20-25%
40-45%
50-60%
80-85%

Explanation

Question 15 of 35

1

Roughly how much primary urine is produced per day?

Select one of the following:

140L
200L
140ml
500L
10L

Explanation

Question 16 of 35

1

Roughly how much filtered fluid is reabsorbed?

Select one of the following:

99%
1%
20%
50%
75%

Explanation

Question 17 of 35

1

Drag and drop the right answer. all answers match up with a space, there are none spare.
For the 0 options, the 00 is in the % column and the normal 0 is in the urine column)

Drag an answer into the correct orange point.

17

0.63

0.5

12.9

125

33

1.4

0.128

0.06

0.0048

0.134

0

18

1.8

0.72

9.5

0.96

1

00

55

130

Explanation

Question 18 of 35

1

drag and drop

Drag an answer into the correct orange point.

Proximal convoluted tubule

glomerulus

Glomerular capsule

efferent arteriole

blood flow

afferent arteriole

glomerular filtrate

fenestrae

podocyte

capillary endothelium

Explanation

Question 19 of 35

1

Glomerular capillaries are __________

Select one of the following:

fenestrated
continuous

Explanation

Question 20 of 35

1

Endothelial cells _______ determine the permselectivity of the glomerular barrier.

Select one of the following:

do
do not

Explanation

Question 21 of 35

1

The endothelial cell coat has _________

Select one of the following:

charge-selective properties
no charge-selective properties.
size selective properties
molecular weight selective properties

Explanation

Question 22 of 35

1

_ density of fenestrae facilitates _ permeability

Select one of the following:

high, high
low, low
high, low
low, high

Explanation

Question 23 of 35

1

Which of these are important components that contribute to the selective properties of the glomerular basement membrane barrier?

Select one or more of the following:

ptoteoglycans such as agrin
ptoteoglycans such as perlecan
glycoproteins

Explanation

Question 24 of 35

1

Where is the endothelial cell surface layer?

Select one of the following:

on the luminal side of the blood vessels
on the fenestrated side of the blood vessels
on the outside of the blood vessels
within the glomerulus

Explanation

Question 25 of 35

1

What are the 2 components of the endothelial cell surface layer?

Select one or more of the following:

the glycocalyx
the endothelial cell coat
the endometrial cell jacket
the caloglycax
the glucose layer

Explanation

Question 26 of 35

1

Thye glycocalyx is the...

Select one of the following:

plasma-membrane-bound part of the layer
the more loosely associated part of the layer

Explanation

Question 27 of 35

1

Thye endothelial cell coat is the...

Select one of the following:

more loosely associated part of the layer
plasma-membrane-bound part of the layer

Explanation

Question 28 of 35

1

*** The endothelial cell surface layer is composed of....

Select one or more of the following:

negatively charged glycoproteins
glycosaminoglycans
membrane associated and secreted proteoglycans

Explanation

Question 29 of 35

1

drag and drop the substances along the graph in relation to where there relative permeability lies

Drag an answer into the correct orange point.

H2O

NaCl

Glucose

Inulin

Myoglobin

Hemoglobin

Albumin

Explanation

Question 30 of 35

1

Filtration of solutes that are not reabsorbed serves as an ineffective mechanism for their excretion

Select one of the following:

True
False

Explanation

Question 31 of 35

1

Which of these about polo trees are true?

Select one or more of the following:

Have long extending cytoplasmic foot processes
Foot processes are separated by a filtration slit
The filtration slit is 25-60nm wide
The filtration slit is covered by a diaphragm
One of the proteins that make up the diaphragm is nephrin
Nephrin is very safe

Explanation

Question 32 of 35

1

When mutated, nephrin...

Select one or more of the following:

Causes massive leakage of protein
Causes severe consequences for patients with congenital nephrotic syndrome.
Causes the diaphragm in the kidney to close
Causes excess water to be absorbed
Causes alcoholism

Explanation

Question 33 of 35

1

The basement membrane allows free passage of neutral molecules up to...

Select one of the following:

6Kd MW (18A radius)
16Kd MW (8A radius)
12Kd MW (24A radius)
2A MW (7Kd radius)

Explanation

Question 34 of 35

1

Negatively charged pores restrict passage of .... molecules

Select one of the following:

Large
Small
Medium
Long
Short

Explanation

Question 35 of 35

1

In disease states, protein Irial may be due to loss of negatively charge selectivity or to increasing numbers of large size pores

Select one of the following:

True
False

	Created by Alannah McDonnell over 6 years ago

- Renal physiology Quiz on Lecture 3 - GFR, created by Alannah McDonnell on 04/04/2018.

Lecture 3 - GFR

Lecture 3 - GFR

Question 1 of 35

What is normal GFR in adult humans?

Select one of the following:

Explanation

Question 2 of 35

What does glomerular ultra-filtrate consist of?

Select one or more of the following:

Explanation

Question 3 of 35

Glomerular Ultrafiltrate is normally ...

Select one of the following:

Explanation

Question 4 of 35

What does Regulated reabsorption of water and solutes allow for?

Select one or more of the following:

Explanation

Question 5 of 35

Which of these are freely filtered but not reabsorbed?

Select one or more of the following:

Explanation

Question 6 of 35

Permselectivity = the restriction of the ❌ of ❌ across ❌ on the basis of ❌ size, charge, and physical ❌

Drag and drop to complete the text.

Explanation

Question 7 of 35

Podocytes = ❌, highly ❌ cells which line the ❌ of glomerular ❌ and thus face the ❌ and the primary ❌

Drag and drop to complete the text.

Explanation

Question 8 of 35

Podocytes have a ____ cell body

Select one of the following:

Explanation

Question 9 of 35

The diaphragm in the podocyte covers the...

Select one of the following:

Explanation

Question 10 of 35

What type of collagen composes the backbone of the fibrous network in the glomerular basement membrane?

Select one of the following:

Explanation

Question 11 of 35

What is the normal urine flow rate in adult humans?

Select one of the following:

Explanation

Question 12 of 35

What is the normal renal blood flow rate in adult humans?

Select one of the following:

Explanation

Question 13 of 35

What is the normal renal plasma flow rate in adult humans?

Select one of the following:

Explanation

Question 14 of 35

what does the filtration fraction generally measure?

Select one of the following:

Explanation

Question 15 of 35

Roughly how much primary urine is produced per day?

Select one of the following:

Explanation

Question 16 of 35

Roughly how much filtered fluid is reabsorbed?

Select one of the following:

Explanation

Question 17 of 35

Drag and drop the right answer. all answers match up with a space, there are none spare. For the 0 options, the 00 is in the % column and the normal 0 is in the urine column)

Drag an answer into the correct orange point.

Explanation

Question 18 of 35

drag and drop

Drag an answer into the correct orange point.

Explanation

Question 19 of 35

Glomerular capillaries are __________

Select one of the following:

Explanation

Question 20 of 35

Drag and drop the right answer. all answers match up with a space, there are none spare.
For the 0 options, the 00 is in the % column and the normal 0 is in the urine column)

_ density of fenestrae facilitates _ permeability