GEGE2001 Week 03 (L05 & L06)

Question 1 of 15

2

(from end of L05 slides)
In a particular cell, a non Watson-Crick base pair (T-G) is formed during DNA replication. What is likely to happen next?

Select one of the following:

Polymerase *probs* removes it, often via 3' exonuclease activity
Polymerase *probs* removes it, often via 5' exonuclease activity
Polymerase *probs* removes it, often via 3' endonuclease activity
Polymerase *probs* removes it, often via 5' endonuclease activity

Explanation

Question 2 of 15

2

(from end of L05 slides)
How does a frameshift mutation differ from a missense mutation?

Select one of the following:

Missense affects many codons; Frameshift mutation does not.
Frameshift affects many codons; Missense mutation does not.
Frameshift affects many codons; Missense mutation only affects 3.
Missense affects many codons; Frameshift mutation only affects 3.

Explanation

Question 3 of 15

2

(from end of L05 slides)
Did the fluctuation test show that bacterial cells induce mutation upon exposure to the selective agent (viral infection)? Explain. (well, don’t explain here, but be ready to)

Select one of the following:

No.
Yes.

Explanation

Question 4 of 15

1

DNA is replicated in:

Select one of the following:

S phase
M phase
G phase
Cytokinesis
Telekinesis

Explanation

Question 5 of 15

2

UV:

Select one or more of the following:

light has HIGH energy
light has LOW energy
damage forms a join between two adjacent bases, usually Thymine (forming a Thymine dimer)
damage forms a join between two adjacent bases, usually Cytosine (forming a Cytosine dimer)
damage forms a join between two adjacent bases, usually Adenosine (forming a Adenosine dimer)
damage forms a join between two adjacent bases, usually Guanine (forming a Guanine dimer)
damage forms a join between two adjacent bases, usually Adenine (forming a Adenine dimer)

Explanation

Question 6 of 15

1

Which of the following is NOT a type of DNA mutation (necessarily)?

Select one or more of the following:

Indels
Incels
Transitions
Transversions

Explanation

Question 7 of 15

2

Types of mutations AT THE PROTEIN-CODING LEVEL. Fill in the blanks:
Silent mutation: ❌;
Missense mutation: ❌;
Nonsense mutation: ❌;
Frameshift ❌.

Drag and drop to complete the text.

bp change, NO amino acid sequence change

bp change, amino acid change

bp change, early stop codon

1bp+ indel, alters reading frame

Explanation

Question 8 of 15

1

UV repair in humans is through:

Select one or more of the following:

Nucleotide excision repair
Enzyme photolyase

Explanation

Question 9 of 15

1

A mutation resulting in COPY NUMBER VARIATION can vary between identical twins. Therefore it happens during:

Select one of the following:

Mitosis
Meiosis
Both of the above
None of the above

Explanation

Question 10 of 15

1

What does the image above show?

Select one or more of the following:

Gene expression of different members of a gene family varying in different parts of the same plant
Gene expression of different members of a gene family varying in different stages of the same plant's development

Explanation

Question 11 of 15

2

(from end of L06 slides)
Variation in gene regulation = mutations that alter the amount of protein product, without a chance in the amino acid sequence. Basically a regulatory mutation. This can be in which of the following:

Select one or more of the following:

promoters
introns
5’-UTR
3’-UTR
exons
5’-URT
3’-URT

Explanation

Question 12 of 15

1

Blonde vs brown-hair is an example of variation in:

Select one of the following:

gene expression
aa sequence
gene splicing

Explanation

Question 13 of 15

2

(from end of L06 slides)
Define a gene family:

Select one of the following:

A set of several similar genes, formed by duplication of a single original gene
A set of several copies of identical genes, responsible for varying levels of a single trait

Explanation

Question 14 of 15

1

(from end of L06 slides)
What is a pseudogene?

Select one or more of the following:

A non-functional copy of a gene including a regulatory mutation that prevents its expression
A non-functional copy of a gene including a premature stop codon within the gene that prevents its expression

Explanation

Question 15 of 15

2

(from end of L06 slides)
What are the 2 most likely sources of phenotypic and genomic variation between individuals within a species? (…excluding environmental factors for some reason)

Select one or more of the following:

Variation in amino acid sequences
Regulatory sequences
Variation in gene number
Variation in splicing
Novel genes

	Created by Michael Jardine over 6 years ago

L05 - Mutation and repair: - Errors and repair; - Types of mutations; - Consequences of mutation L06 - Mutation and phenotypic variation: - Phenotypic differences can be obtained by: * Adding sequences to the genome; * Changing sequences or gene expression; * Changing the environment

GEGE2001 Week 03 (L05 & L06)

Question 1 of 15

(from end of L05 slides) In a particular cell, a non Watson-Crick base pair (T-G) is formed during DNA replication. What is likely to happen next?

Select one of the following:

Explanation

Question 2 of 15

(from end of L05 slides) How does a frameshift mutation differ from a missense mutation?

Select one of the following:

Explanation

Question 3 of 15

(from end of L05 slides) Did the fluctuation test show that bacterial cells induce mutation upon exposure to the selective agent (viral infection)? Explain. (well, don’t explain *here*, but be ready to)

Select one of the following:

Explanation

Question 4 of 15

DNA is replicated in:

Select one of the following:

Explanation

Question 5 of 15

UV:

Select one or more of the following:

Explanation

Question 6 of 15

Which of the following is NOT a type of DNA mutation (necessarily)?

Select one or more of the following:

Explanation

Question 7 of 15

Types of mutations AT THE PROTEIN-CODING LEVEL. Fill in the blanks: Silent mutation: ❌; Missense mutation: ❌; Nonsense mutation: ❌; Frameshift ❌.

Drag and drop to complete the text.

Explanation

Question 8 of 15

UV repair in humans is through:

Select one or more of the following:

Explanation

Question 9 of 15

A mutation resulting in COPY NUMBER VARIATION can vary between identical twins. Therefore it happens during:

Select one of the following:

Explanation

Question 10 of 15

What does the image above show?

Select one or more of the following:

Explanation

Question 11 of 15

(from end of L06 slides) Variation in gene regulation = mutations that alter the amount of protein product, without a chance in the amino acid sequence. Basically a regulatory mutation. This can be in which of the following:

Select one or more of the following:

Explanation

Question 12 of 15

Blonde vs brown-hair is an example of variation in:

Select one of the following:

Explanation

Question 13 of 15

(from end of L06 slides) Define a gene family:

Select one of the following:

Explanation

Question 14 of 15

(from end of L06 slides) What is a pseudogene?

Select one or more of the following:

Explanation

Question 15 of 15

(from end of L06 slides) What are the 2 most likely sources of phenotypic and genomic variation between individuals within a species? (…excluding environmental factors for some reason)

Select one or more of the following:

Explanation

(from end of L05 slides)
In a particular cell, a non Watson-Crick base pair (T-G) is formed during DNA replication. What is likely to happen next?

(from end of L05 slides)
How does a frameshift mutation differ from a missense mutation?

(from end of L05 slides)
Did the fluctuation test show that bacterial cells induce mutation upon exposure to the selective agent (viral infection)? Explain. (well, don’t explain here, but be ready to)

Types of mutations AT THE PROTEIN-CODING LEVEL. Fill in the blanks:
Silent mutation: ❌;
Missense mutation: ❌;
Nonsense mutation: ❌;
Frameshift ❌.

(from end of L06 slides)
Variation in gene regulation = mutations that alter the amount of protein product, without a chance in the amino acid sequence. Basically a regulatory mutation. This can be in which of the following:

(from end of L06 slides)
Define a gene family:

(from end of L06 slides)
What is a pseudogene?

(from end of L06 slides)
What are the 2 most likely sources of phenotypic and genomic variation between individuals within a species? (…excluding environmental factors for some reason)