Matthew Coulson
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Neurobiology of Addiction lecture given on 05/10/2018

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Matthew Coulson
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Neurobiology of Addiction

Neurobiology of Addiction

Question 1 of 9

1

Fill the blank spaces to complete the text.

The reward pathway, in the most basic sense, begins in the floor of the midbrain at the (clue: VTA), which then projects to the . This structure then projects finally to the cortex.

Explanation

Question 2 of 9

1

The reward pathway is also known as the

Select one of the following:

  • Mesolimbic Pathway

  • Mesocortical Pathway

  • Nigrostriatal Pathway

  • Tuberoinfundibular Pathway

Explanation

Question 3 of 9

1

The mesolimbic pathway is one of the four ...

Select one of the following:

  • Dopaminergic Pathways

  • Adrenergic Pathways

  • Glutamatergic Pathways

Explanation

Question 4 of 9

1

In terms of the nucleus accumbens, overexpression of which gene transcription factor is thought to be the main influencer of addiction?

Select one of the following:

  • ΔFosB

  • ΔJunD

  • cAMP

  • CREB

  • NFκB

Explanation

Question 5 of 9

1

Patients showing addictive behaviours tend to have a preserved insight; they know they are unwell.

Select one of the following:

  • True
  • False

Explanation

Question 6 of 9

1

Dopamine release usually has the ability to update info and set new goals in the prefrontal cortex, thus having the ability to avoid compulsive repetition of a behaviour. Addictive drugs provide a potent dopamine signal which disrupts the normal dopamine learning pathway in the prefrontal cortex.

Select one of the following:

  • True
  • False

Explanation

Question 7 of 9

1

On average, those who start experimenting with drugs earlier in life tend to have a shorter relationship with drugs.

Select one of the following:

  • True
  • False

Explanation

Question 8 of 9

1

Which part of the frontal cortex concerns the following:
Emotion and reward in decision making; hyperactivity of this area during addiction behaviour represents craving

Select one of the following:

  • Orbitofrontal Cortex

  • ‎Ventrolateral Prefrontal Cortex

  • ‎Dorsolateral Prefrontal Cortex

Explanation

Question 9 of 9

1

Select from the dropdown lists to complete the text.

In ( non-addicted, addicted ) brains, areas such as the Anterior Cingulate Gyrus send inhibitory signals to the orbitofrontal cortex and thus the sensation of craving ( does not, does ) occur.
In ( addicted, non-addicted ) brains, the nucleus accumbens sends inhibitory signals to areas such as the Anterior Cingulate Gyrus so that the inhibitory signals are not sent to the Orbitofrontal cortex and thus the sensation of craving ( does, does not ) occur

Explanation

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