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Pharmacology- Antimicrobial Drugs- Sulfonamides and Quinolones- 4th Year- PMU

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Pharmacology- Antimicrobial Drugs- Sulfonamides and Quinolones- 4th Year- PMU

Question 1 of 11

1

Sulfonamides for topical application on skin and mucous membranes are:

Select one or more of the following:

  • Sulfadiazine

  • Sulfacetamide

  • Sulfisoxazole

  • Co-trimoxazole

Explanation

Question 2 of 11

1

Sulfonamides for oral administration are:

Select one or more of the following:

  • Co-trimoxazole

  • Sulfacetamide

  • Sulfaguanidine

  • Sulfisoxazole

Explanation

Question 3 of 11

1

Mechanism of action of sulfonamide is:

Select one or more of the following:

  • they are synthetic analogues of p-aminobenzoic acid (PABA) and complete with it for the enzyme dihydropteroate synthetase

  • they increase the permeability of the bacterial cell membrane

  • they inhibit bacterial wall synthesis

  • they inhibit the synthesis of bacterial dihydrofolic acid

Explanation

Question 4 of 11

1

For non-combined sulfanamides is true:

Select one or more of the following:

  • have broad antibacteriai spectrum

  • have narrow antibacterial spectrum

  • they are bactericidal

  • they are bacteriostatic

Explanation

Question 5 of 11

1

Co-trimoxazole:

Select one or more of the following:

  • contains trimethoprim and sulfamethoxazole

  • contains sulfadoxine and pyrimethamine

  • has bactericidal effect

  • is taken every 12 hours

Explanation

Question 6 of 11

1

Fansidar:

Select one or more of the following:

  • is used as an antimalarial drug

  • is combined drug containing long-acting sulfonamide

  • mains sulfadoxine and pyrimethamine

  • contains trimethoprim and sulfamethoxazole

Explanation

Question 7 of 11

1

Combined sulfonamides are:

Select one or more of the following:

  • bacteriostatic drugs

  • bactericidal drugs

  • antiviral drugs

  • narrow spectrum antimicrobial drugs

Explanation

Question 8 of 11

1

Crystalluria caused by sulfonamides may be prevented by:

Select one or more of the following:

  • administration of folic acid

  • adequate hydration

  • alkalinization of urine

  • acidification of urine

Explanation

Question 9 of 11

1

Adverse drug reactions of sulfonamides are:

Select one or more of the following:

  • hemapoietic disturbances

  • heart failure

  • hypersensitivity

  • crystalluria

Explanation

Question 10 of 11

1

Sulfonamides are contraindicated in:

Select one or more of the following:

  • renal or liver impairment

  • pregnancy and breast-feeding

  • new-borns and infants less than 2 months of age

  • arterial hypertension

Explanation

Question 11 of 11

1

Drug interactions of sulfonamides are:

Select one or more of the following:

  • petentiation of the effect of oral anticoagulants (warfarin)

  • antagonism when applied together with penicillines

  • synergism when applied together with penicillines

  • potentiation of the hypoglycaemic effect of oral antidiabetic

Explanation

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