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Pharmacology- Fluoroquinolones- 4th Year PMU

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Pharmacology- Fluoroquinolones- 4th Year PMU

Pharmacology- Fluoroquinolones- 4th Year PMU

Question 1 of 8

1

Fluoroquinoiones are:

Select one or more of the following:

  • Gentamycin

  • Moxifloxacin

  • Ciprofloxacin

  • Levofloxacin

Explanation

Question 2 of 8

1

Mechanism of action of quinolones is:

Select one or more of the following:

  • inhibition of protein synthesis

  • inhibition of cell wall synthesis

  • inhibition of topoisomerase II and IV

  • inhibition of DNA transcription and replication

Explanation

Question 3 of 8

1

Fluoroquinolones have:

Select one or more of the following:

  • broad antibacterial spectrum

  • narrow antibacterial spectrum

  • bacteriostatic effect

  • bactericidal effect

Explanation

Question 4 of 8

1

Point out the correct statements for pharmacokinetics of fluoroquinolones:

Select one or more of the following:

  • bad oral absorption and are administered always parenterally

  • distribute well into all tissues and body fluids

  • inhibit some liver cytochromes

  • most of them are excreted renally

Explanation

Question 5 of 8

1

Fluoroquinolones are used for treatment of:

Select one or more of the following:

  • Urinary tract infections

  • Respiratory infections

  • Skin infections

  • Gl infections

Explanation

Question 6 of 8

1

Adverse drug reactions of fluoroquinolones are:

Select one or more of the following:

  • articular cartilage erosion (arthropathy)

  • hypertension

  • seizures in patients with epilepsy

  • prolongation of QT interval

Explanation

Question 7 of 8

1

Quinolones are contraindicated in

Select one or more of the following:

  • pregnancy and breast-feeding

  • children under 18 years of age

  • patients with epilepsy

  • patients with renal failure

Explanation

Question 8 of 8

1

Drug interactions of fluoroquinolones are:

Select one or more of the following:

  • increase serum levels of theophyiline by inhibiting its metabolism

  • decrease serum levels of theophyiline by inducing its metabolism

  • synergism with beta-lactams

  • calcium and other divalent cations decrease their absorption

Explanation

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