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Antibacterial Drugs (Antibiotics)

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Antibacterial Drugs (Antibiotics)- Pharmacology- 4th Year- PMU

Antibacterial Drugs (Antibiotics)- Pharmacology- 4th Year- PMU

Question 1 of 42

1

Bactericidal antibacterial drugs:

Select one or more of the following:

  • inhibit the growth of microorganisms

  • inhibit the multiplication of microorganisms

  • kill the microorganisms

  • block the enzyme penicillinase

Explanation

Question 2 of 42

1

Antimicrobials with bactericidal activity are:

Select one or more of the following:

  • beta-lactam antibiotics

  • amphenicols and lincosamides

  • aminoglycosides

  • quinolones

Explanation

Question 3 of 42

1

Bacteriostatic action means:

Select one or more of the following:

  • inhibition of the growth of microorganisms

  • inhibition of the multiplication of microorganisms

  • destruction of microorganisms

  • inhibition of the enzyme penicillinase

Explanation

Question 4 of 42

1

Bacteriostatic antimicrobials are:

Select one or more of the following:

  • amphenicols

  • aminoglycosides

  • tetracyclines and macroiides

  • lincosamides

Explanation

Question 5 of 42

1

Narrow spectrum antimicrobial drugs are active against:

Select one or more of the following:

  • Gram (+) cocci

  • Gram (+) bacteria

  • Fungi and viruses

  • Parasites

Explanation

Question 6 of 42

1

Antimicrobials with a narrow spectrum of activity are:

Select one or more of the following:

  • classic penicillins

  • lincosamides

  • aminoglycosides

  • classic macrolides

Explanation

Question 7 of 42

1

Antimicrobials with broad spectrum of activity are:

Select one or more of the following:

  • cephalosporins

  • aminopenicilins

  • lincosamides

  • rifamycins

Explanation

Question 8 of 42

1

Antimicrobials that inhibit bacterial cell wall synthesis are:

Select one or more of the following:

  • penicillins

  • cephalosporins

  • monobactams

  • tetracyclines

Explanation

Question 9 of 42

1

Antimicrobial that inhibit protein synthesis in microorganisms are:

Select one or more of the following:

  • tetracyclines

  • macrolldes

  • quinolones

  • carbapenems

Explanation

Question 10 of 42

1

Antibiotics that inhibit DNA synthesis in microorganisms are

Select one or more of the following:

  • cephalosporins

  • quinolones

  • macrolides

  • rifampicin

Explanation

Question 11 of 42

1

Antibiotics that must be avoided during pregnancy are:

Select one or more of the following:

  • tetracyclines

  • penicillins

  • cephalosporins

  • rifampicin

Explanation

Question 12 of 42

1

Antimicrobial agents with urine excretion are:

Select one or more of the following:

  • penicillins

  • cephalosporins

  • aminoglycosides

  • quinolones

Explanation

Question 13 of 42

1

Antimicrobial agents with bile excretion are:

Select one or more of the following:

  • tetracyclines

  • aminoglycosides

  • macrolides

  • sulfonamides

Explanation

Question 14 of 42

1

Optimal combinations of antimicrobial agents are:

Select one or more of the following:

  • bactericidal antibiotics with bactericidal antibiotics

  • tetracyclines with macrolides

  • bactericidal antibiotics with bacteriostatic antibiotics

  • penicillins with B-lactamase inhibitors

Explanation

Question 15 of 42

1

Tetracyclines

Select one or more of the following:

  • are bactericidal

  • ae bacterostatic

  • accumulate in tissues- in bones and teeth

  • are effective against rickettsiae, mycoplasma, chlamydia

Explanation

Question 16 of 42

1

Which foods and drugs interact with tetracyclines' gastrointestinal absorption?

Select one or more of the following:

  • Vitamin B1

  • Yogurt or Cheese

  • Fe2+ or Mg2+ containing drugs

  • Aminoglycosides

Explanation

Question 17 of 42

1

Adverse drug reactions of tetracyclines are:

Select one or more of the following:

  • nephro-and ototoxicity

  • hepatotoxicity

  • yellow-brown discoloration of teeth and frequent tooth decay in children

  • inhibition of bone growth in children

Explanation

Question 18 of 42

1

Tetracyclines are contraindicated in:

Select one or more of the following:

  • pregnancy

  • children less than 8 years

  • liver failure

  • heart failure

Explanation

Question 19 of 42

1

Macrolide antibiotics are:

Select one or more of the following:

  • Azithromycin (Azatril)

  • Roxithromycin (Rulid)

  • Clarithroomycin (Klacid)

  • Gentamycin

Explanation

Question 20 of 42

1

Macrolides are:

Select one or more of the following:

  • bactericidal

  • bacteriostatic

  • inhibitors of methylxanthines’ metabolism

  • effective against mycoplasmas, Legionella, Chlamydia

Explanation

Question 21 of 42

1

Adverse drug reactions of macrolides include:

Select one or more of the following:

  • gastrointestinal disturbances

  • allergy

  • hepatotoxicity

  • nephrotoxicity

Explanation

Question 22 of 42

1

Macrolides are contraindicated in:

Select one or more of the following:

  • Pregnancy in the first half

  • G-6-PDH deficiency

  • Liver failure

  • Breastfeeding

Explanation

Question 23 of 42

1

Lincosamides:

Select one or more of the following:

  • are bacteriostatic antibiotics

  • are appropriate for the treatment of staphylococcal osteomyelitis

  • can be hepato- and haematotoxic

  • accumulate in the bone marrow

Explanation

Question 24 of 42

1

Lincosamides are contraindicated in:

Select one or more of the following:

  • pregnancy

  • children less than 2 years

  • liver failure

  • heart failure

Explanation

Question 25 of 42

1

Chloramphenicol:

Select one or more of the following:

  • is a bactericidal antibiotic

  • is effective against Gram (-) microorganisms

  • is a tetracycline derivative

  • inhibits alcohol dehydrogenase enzyme

Explanation

Question 26 of 42

1

The correct statements for Chloramphenicol are:

Select one or more of the following:

  • It is used as a reserve antibiotic because of many ADRs

  • Causes gastrointestinal disbacteriosis

  • Can be administered orally

  • It Is used for the treatment of tuberculosis

Explanation

Question 27 of 42

1

Adverse drug reactions of Chloramphenicol are:

Select one or more of the following:

  • damage of teeth enamel

  • "gray baby" syndrome

  • disulfiram- alcohol reaction

  • bone marrow supression (myelotoxicity)

Explanation

Question 28 of 42

1

Chloramphenicol is contraindicated in:

Select one or more of the following:

  • Pregnancy

  • Children less than 2 years

  • Alcoholism

  • G-6-PDH deficiency

Explanation

Question 29 of 42

1

Beta-lactam antibiotics are

Select one or more of the following:

  • penicillins

  • cephalosporins

  • monobactams

  • carbapenems

Explanation

Question 30 of 42

1

Narrow spectrum (classic) penicillins are:

Select one or more of the following:

  • Amoxicillin

  • Benzylpeniciliin (Penicilin G)

  • Phenoxymethylpenicillin (Ospen)

  • Oxacillin

Explanation

Question 31 of 42

1

Broad spectrum semisynthetic penicillins are:

Select one or more of the following:

  • Amoxicillin (Amopen)

  • Ampicillin

  • Azlocillin

  • Gentamycin

Explanation

Question 32 of 42

1

Adverse drug reactions of penicillins are:

Select one or more of the following:

  • allergic reactions

  • hepatotoxicity

  • anaphylactic shock

  • disbactenosrs (for orally administered broad-spectrum penicillins)

Explanation

Question 33 of 42

1

Penicillins and cephalosporins block the synthesis of:

Select one or more of the following:

  • the bacterial cell wall

  • the bacterial membrane

  • proteins

  • nucleic acids

Explanation

Question 34 of 42

1

Cephalosporins 1st generation are:

Select one or more of the following:

  • More effective against Gram (+) microorganisms

  • Cefalexin and Cefazolin

  • Bacteriostatic

  • Some agents are nephrotoxic

Explanation

Question 35 of 42

1

Cephalosporins 2nd generation are:

Select one or more of the following:

  • Bactericidal

  • Cefaclor and Cefamandol

  • More effective against Gram (-) organisms: Klebsiella, H. lnfluenzae

  • With high bile concentrations (most of them)

Explanation

Question 36 of 42

1

Cephalosporins 3rd generation are:

Select one or more of the following:

  • Cefetamet and Ceftriaxon

  • Cefaclor and Cefamandol

  • More effective against Gram (-) microorganisms

  • Used for treatment of life-threatening infections

Explanation

Question 37 of 42

1

Cephalosporins 4th generation are:

Select one or more of the following:

  • Cefepim and Cefpifom

  • Narrow spectrum antibiotics

  • Effective against Gram (-) microorganisms as 3rd generation and against Gram (+) as 1st generation cephalosporins

  • Used for treatment of life-threatening infections

Explanation

Question 38 of 42

1

Adverse drug reactions of cephalosporins are:

Select one or more of the following:

  • allergic reactions

  • suppressed vitamin K synthesis

  • hepatotoxicity

  • nephrotoxicity

Explanation

Question 39 of 42

1

Aminoglycoside antibiotics are:

Select one or more of the following:

  • Gentamaicin

  • Amoxiclav

  • Amikacin

  • Tobramycin

Explanation

Question 40 of 42

1

The correct statements of aminoglycoside antibiotics are:

Select one or more of the following:

  • they block protein synthesis and are bactericidal

  • they accumulate in soft tissues and bones

  • they are administrated orally for treatment of urinary infections

  • they are effective against Gram (-) microorganisms

Explanation

Question 41 of 42

1

Adverse drug reactions of aminoglycosides are:

Select one or more of the following:

  • nephrotoxicity

  • ototoxicity

  • myelotoxlcity

  • hepatotoxiclty

Explanation

Question 42 of 42

1

Aminoglycosides are contraindicated in:

Select one or more of the following:

  • pregnancy

  • children less than 2 years

  • renal failure

  • liver failure

Explanation

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