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AntiFungal, Antiviral and Antimycobacerial Drugs- Pharmacology- 4th Year- PMU

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AntiFungal, Antiviral and Antimycobacerial Drugs- Pharmacology- 4th Year- PMU

Question 1 of 33

1

Antifungals are:

Select one or more of the following:

tetracyclines
imidazoles
echinocandims
triazols

Explanation

Question 2 of 33

1

Synthetic antifungal drugs are

Select one or more of the following:

Nystatin
Itraconazole
Ketoconazole
Fluconazole

Explanation

Question 3 of 33

1

Antifungal antibiotics are:

Select one or more of the following:

Nystatin
Tetracycline
Gentamycin
Amphotericin B

Explanation

Question 4 of 33

1

Azoles:

Select one or more of the following:

are fungistatic
inhibit cell wall synthesis
inhibit ergosterol synthesis
inhibit hepatic CYP450 enzymes

Explanation

Question 5 of 33

1

lmidazoles are:

Select one or more of the following:

Fluconazole and ltraconazole
Miconazole and Econazole
Given topically
Given systematically

Explanation

Question 6 of 33

1

Ketoconazole is:

Select one or more of the following:

the only imidazole that can be given orally
used for treatment of bacterial skin infections
used topically for cutaneous fungal infections
used intravenously for treatment of systemic fungal infections

Explanation

Question 7 of 33

1

Fluconazole:

Select one or more of the following:

it is non- steroidal anti-inflammatory drug
is triazole antifungal drug
is administered orally or intravenously
is excreted mainly unchanged with the urine

Explanation

Question 8 of 33

1

ADRs of azole antifungals are:

Select one or more of the following:

hepatotoxicity
endocrine disorders
nephrotoxicity
nausea, vomiting

Explanation

Question 9 of 33

1

Point the correct statements for Nystatin:

Select one or more of the following:

has fungistatic activity
causes gastrointestinal disturbances
is effective against Trichomonas vaginalis
is effective against Candida species

Explanation

Question 10 of 33

1

ADRs of Amphoteracin B are:

Select one or more of the following:

renal impairment
hypokalemia
hypotension
liver impairment

Explanation

Question 11 of 33

1

Antiviral drugs act by following mechanisms

Select one or more of the following:

inhibition of viral “uncoating”
inhibition of viral DNA or RNA synthesis
inhibition of viral proteases
inhibition of viral penetration into the cell

Explanation

Question 12 of 33

1

Point out the correct statements for Aciclovir:

Select one or more of the following:

it inhibits viral DNA polymerase
it is used for “treatment of herpesvirus infections
it inhibits neuraminidase enzyme
can be applied topically, orally or intravenously

Explanation

Question 13 of 33

1

ADRs of Aciclovir are:

Select one or more of the following:

hepatotoxicity
renal impairment
local irritation
encephalopathy (at high i.v. doses)

Explanation

Question 14 of 33

1

Drugs for prevention and treatment of flu are:

Select one or more of the following:

Aciclovir (Zovirax)
Amantadin (Symmetrel)
Rimantadin (Flumadine)
Oseltamivir (Tamiflu)

Explanation

Question 15 of 33

1

Mechanism of action of Oseltamivir (Tamiflu) is

Select one or more of the following:

interference with the function of the viral M2 protein
inhibition of specific neuraminidase enzyme
inhibition of reverse transcriptases
inhibition of proteases

Explanation

Question 16 of 33

1

For Amantadine and Rimantadine is true:

Select one or more of the following:

resistance can develop rapidly
they are effective against both type A and type B influenza
they are effective against type A influenza viruses
they interfere with the function of the viral M2 protein and block uncoating of the Virus particles

Explanation

Question 17 of 33

1

Mechanisms of action of drugs for treatment of HIV infection are:

Select one or more of the following:

inhibition of reverse transcriptase
inhibition of HIV protease
inhibition of HIV entry into the host cell
inhibition of the insertion of proviral DNA. into the host cell genome

Explanation

Question 18 of 33

1

Point out the correct statements for Zidovudin;

Select one or more of the following:

it blocks HIV reverse transcriptase
it blocks HIV protease
it is a nucleoside analogue
it can cause anemia and neutropenia

Explanation

Question 19 of 33

1

ADRS of Nucleoside and nucleotide reverse transcriptase inhibitors (NRTIs) are:

Select one or more of the following:

peripheral neuropathy
pancreatitis
polymyositis
glaucoma

Explanation

Question 20 of 33

1

HIV protease inhibitors are:

Select one or more of the following:

Zidovudin
Indinavir
Ritonavir
Aciclovir

Explanation

Question 21 of 33

1

For HIV protease inhibitors is true:

Select one or more of the following:

protease inhibition prevents maturation of the viral particles
they are enzyme inducers
they are enzyme inhibitors
they are combined with other antiretroviral drugs in the treatment of HIV infection

Explanation

Question 22 of 33

1

ADRs of HIV protease inhibitors are:

Select one or more of the following:

hyperlipidaemia
insulin resistance and hyperglycaemia
hypoglycaemia
fat redistribution

Explanation

Question 23 of 33

1

Inhibitor of both hepatitis B virus (HBV) and HIV reverse transcriptases is:

Select one or more of the following:

Zidovudin
Lamivudin
Aciclovir
lndinavir

Explanation

Question 24 of 33

1

Protease inhibitor for treatment of chronic hepatitis C infection is:

Select one or more of the following:

Aciclovir
Telaprevir
Zidovudin
Oseltamivir

Explanation

Question 25 of 33

1

Antimycobacterial drugs are:

Select one or more of the following:

Rifampicin
Isoniazid
Ethambutol
Amoxicillin

Explanation

Question 26 of 33

1

Rifampicin (Rifampin):

Select one or more of the following:

is bactericidal antibiotic with antimycobacterial activity
is antiviral drug
is broad spectrum antibiotic
is enzyme inducer

Explanation

Question 27 of 33

1

Mechanism of action of Rifampicin (Rifampin) is

Select one or more of the following:

inhibition of cell wall synthesis
inhibition of 50 S ribosomal subunit
inhibition of DNA-dependent RNA polymerase
increased cell membrane permeability

Explanation

Question 28 of 33

1

ADRs of Rifampicin (Rifampin) are:

Select one or more of the following:

heart failure
orange-red color of urine and other secretions
hepatotoxicity
hypoglycaemia

Explanation

Question 29 of 33

1

Point out the correct statements for lsoniazid:

Select one or more of the following:

inhibits the synthesis of essential for mycobacteria mycolic acid
it is metabolized by, acetylation
it is specific for treatment of M. Tuberculosis
it is active against broad spectrum of bacteria

Explanation

Question 30 of 33

1

ADRs of lsoniazld are:

Select one or more of the following:

renal impairment
peripheral neuropathy
convulsions
hepatitis

Explanation

Question 31 of 33

1

lsoniazid-induced peripheral neuropathy can be avoided by:

Select one or more of the following:

supplementation with vitamin B1
supplementation with vitamin A
supplementation with vitamin B6
supplementation with vitamin B12

Explanation

Question 32 of 33

1

ADRs of Pyrazinamide are:

Select one or more of the following:

hepatotoxicity
arrhythmia
hyperuricaemia
hypoglycaemia

Explanation

Question 33 of 33

1

Ethambutol:

Select one or more of the following:

is bacteriostatic antimycobacterial drug
may cause liver failure
may cause optic neuritis
inhibits synthesis of the mycobacterial cell wall

Explanation