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Adrenegic Drugs- Pharmacology 4th Year- PMU

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Adrenegic Drugs- Pharmacology 4th Year- PMU

Question 1 of 31

1

According to their mechanism of action the adrenergic agonists can be divided in:

Select one or more of the following:

  • direct agonists

  • indirect agonists

  • agonists with mixed mechanism of action

  • natural compounds

Explanation

Question 2 of 31

1

α1-adrenoceptors are located on:

Select one or more of the following:

  • presynaptic neuronal endings

  • postsynaptic neuronal endings

  • blood vessels

  • iris dilator muscle

Explanation

Question 3 of 31

1

β1-adrenoceptors are located on:

Select one or more of the following:

  • postsynaptic neuronal endings

  • presynaptic neuronal endings

  • myocardial cells

  • juxtaglomerular apparatus in the kidney

Explanation

Question 4 of 31

1

β2-adrenoceptors are located on:

Select one or more of the following:

  • postsynaptic neuronal endings

  • bronchial smooth muscles

  • liver

  • uterus (womb)

Explanation

Question 5 of 31

1

β3-adrenoceptors are located in:

Select one or more of the following:

  • adipose tissue

  • urinary bladder

  • presynaptic neuronal endings

  • bronchial smooth muscles

Explanation

Question 6 of 31

1

Pharmacological effects of Epinephrine are:

Select one or more of the following:

  • positive chronotropic effect

  • blood pressure elevation

  • bronchial smooth muscles dilation

  • elevated levels of blood sugar

Explanation

Question 7 of 31

1

Indications for the clinical use of Epinephrine are:

Select one or more of the following:

  • anaphylactic shock

  • hypoglycaemia

  • arrhythmia

  • glaucoma with wide iridocorneal angle

Explanation

Question 8 of 31

1

Potential adverse drug reactions of Epinephrine are:

Select one or more of the following:

  • hypoglycaemia

  • arrhythmia

  • tremor

  • anxiety and restlessness

Explanation

Question 9 of 31

1

Clinical indications for prescribing α1-agonists are:

Select one or more of the following:

  • arterial hypotension

  • acute rhinitis

  • asthma attack

  • heart block

Explanation

Question 10 of 31

1

Pharmacological effects of the selective β2-agonists are:

Select one or more of the following:

  • pupillary dilation

  • bronchial dilation

  • blood pressure elevation

  • relaxation of uterine muscle

Explanation

Question 11 of 31

1

Which of the following drugs are selective β2-agonists?

Select one or more of the following:

  • lsoprenalini sulfas

  • Orciprenalini sulfas

  • Salbutamol

  • Salmeterol

Explanation

Question 12 of 31

1

β2-agonists are indicated in:

Select one or more of the following:

  • bronchial asthma

  • digitalis intoxication

  • arterial hypertension

  • threatening abortion

Explanation

Question 13 of 31

1

Adverse drug reactions of β2-agonists are:

Select one or more of the following:

  • finger tremor

  • bronchial dilatation

  • hyperglycemia

  • tolerance

Explanation

Question 14 of 31

1

What are the main features of the indirect-acting adrenergic agonists?

Select one or more of the following:

  • stimulation of central nervous system

  • drug tolerance and dependence

  • have no effect on the cardio-vascular system

  • used for treatment of narcolepsy and attention deficiency hyperactivity disorder (ADHD)

Explanation

Question 15 of 31

1

Clinically desirable interactions can occur between β2-agonists and:(find correct answer)

Select one or more of the following:

  • tricyclic antidepressants

  • inhaled corticosteroids

  • inhaled antimuscarinic drugs

  • beta blockers

Explanation

Question 16 of 31

1

Mechanisms of action of the presynaptic adrenolytics are:

Select one or more of the following:

  • blockade of the presynaptic α2-receptors

  • activation of the presynaptic α2-receptors

  • conversion to a “false“ neurotransmitter

  • blockade of the phosphodiesterase enzyme

Explanation

Question 17 of 31

1

Which of the following drugs act as agonists of the presynaptic α2-adrenoceptors?

Select one or more of the following:

  • Salbutamol

  • Clonidini hydrochloridum

  • α-Methyldopum (Dopegyt)

  • Sotalol

Explanation

Question 18 of 31

1

Pharmacological effects of Clonidin are:

Select one or more of the following:

  • decreased peripheral vascular resistance

  • antihypertensive

  • inhibition of gastric secretion

  • antiarrhythmic

Explanation

Question 19 of 31

1

Adverse drug reactions of Clonidin are:

Select one or more of the following:

  • Dry mouth

  • Drowsiness and depression

  • Hypertensive attacks following abrupt cessation of treatment

  • CNS stimulation

Explanation

Question 20 of 31

1

For Methyldopa is true:

Select one or more of the following:

  • has antihypertensive effect

  • it is safe in pregnancy

  • could cause drug-induced parkinsonism

  • used to treat threatening abortion

Explanation

Question 21 of 31

1

Which of the following drugs are α1-adrenoblockers?

Select one or more of the following:

  • Prazosin

  • Doxazosin

  • Clonidin

  • Chlorpromazin

Explanation

Question 22 of 31

1

Pharmacological effects of Prazosin are:

Select one or more of the following:

  • dilation of the resistive and capacitive vessels

  • antihypertensive

  • relaxation of the muscles in the prostate and bladder neck

  • hyperglycaemia

Explanation

Question 23 of 31

1

Adverse drug reactions of α1-adrenoblockers are:

Select one or more of the following:

  • orthostatic collapse

  • hypokalemia

  • fluid retention

  • hypoglycaemia

Explanation

Question 24 of 31

1

Which of the following drugs are non-selective β-blockers?

Select one or more of the following:

  • Atenolol

  • Pindolol

  • Acebutolol

  • Propranolol

Explanation

Question 25 of 31

1

Which of the following drugs are selective β1-blockers?

Select one or more of the following:

  • Atenolol

  • Pindolol

  • Propranolol

  • Metoprolol

Explanation

Question 26 of 31

1

β-blockers are indicated in case of:

Select one or more of the following:

  • hypertension

  • bronchial asthma

  • arrhythmia

  • ischaemic heart disease

Explanation

Question 27 of 31

1

Pharmacological effects of B-blockers are:

Select one or more of the following:

  • bronchodilation

  • negative inotropic effect

  • positive chronotropic effect

  • negative chronotropic effect

Explanation

Question 28 of 31

1

β-blocker approved for topical use in treatment of glaucoma is:

Select one or more of the following:

  • Bisoprolol

  • Metoprolol

  • Timolol

  • Propranolol

Explanation

Question 29 of 31

1

When applied topically in the eye the B-blocker Timolol will:

Select one or more of the following:

  • increase the intraocular pressure

  • decrease the intraocular pressure

  • cause miosis

  • cause mydriasis

Explanation

Question 30 of 31

1

Potential adverse drug reactions of β-blockers are.

Select one or more of the following:

  • hypoglycaemia

  • bronchoconstriction

  • hyperglycaemia

  • nightmares

Explanation

Question 31 of 31

1

For long-term treatment with β-blockers is true:

Select one or more of the following:

  • up-regulation of B-adrenergic receptors

  • down-regulation of B-adrenergic receptors

  • the therapy should be ceased abruptly

  • the therapy should not be ceased abruptly

Explanation

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