The Nobel Prive this year in Physiology or Medicine went to research on:
Lasers
Climate Change
Immunotherapy and cancer
Improving the welfare of children
Discovery of telomers
The max RF value between 2 genes in coupling is 0.3
True
False
Which of the following does not represent an aneuploid cell?
a triploid cell
a cell with trisomy
a cell with monosomy
a cell from an individual with Klinefelter syndrome
a cell from an individual with Jacob syndrome
A child with Down Syndrome could result from
non-disjunction during meiosis 2
non-disjunction during transcription
non-disjunction during translation
non-disjunction during meiosis 1
two of the above
Live humans can be monosomic for sex chromosomes, but not monosomic for autosomes
true
false
Use the following conditions to answer the question: A. Turner Syndrome B. Edwards syndrome C. Triple X D. Polypoidy E. None of the above
The Human condition where cells have an extra autosome is called-----
A
B
C
D
E
Use the following conditions to answer the question: A. Turner Syndrome B. Edwards syndrome C. Triple X D. Polypoidy E. None of the above The Human condition where cells have a missing sex chromosome is -----
This is seen in some plant cells
Guanylic acid is a -------
base
nucleoside
ribonucleotide
amino-acid
none of the above
What is the structure of B DNA?
Left-handed double helix
right-handed alpha helix
left handed double helix with 10 bp per turn
right-handed double helix
The width of DNA is 20 Angstroms
Based on Griffith's experiment, the following would kill the mouse
heat killed IIIS bacteria and live IIR
heat killed IIR
heat killed IIR and live IIIS
all of the answers are correct
Which of the following represents DNA synthesis?
n(AA) --> (AA)n
n(dXTP)---> (dXMP)n + nPiP
n(XTP)---> (XMP)n + nPiP
n(dXMP)---> (dXMP)n + nPiP
n(dXMP)---> (XTP)n + nPiP
Which of the following is/are True regarding DNA polymerase 1?
it has 5' to 3' polymerase activity
it has ligase activity
it has 3' to 5' exonuclease activity
it has telomerase activity
Meselson and Stahl provided experimental evidence for the conservative model of replication.
Helicase-----while-----topisomerase-------
breaks phosphodiester bonds/ breaks hydrogen bonds
breaks hydrogen bonds/ breaks phosphodiester bonds
breaks peptide bonds/ breaks phosphodiester bonds
breaks ionic bonds/ breaks phosphodiester bonds
Which of the following statements is/are true concerning DNA replication?
both leading and lagging strands are synthesized in a 3' to a 5' direction
the leading strand is synthesized in a 5' to 3' direction, the lagging strand in a 3' to 5' direction
both leading and laggging strands are synthesized in a 5' to 3' direction
DNA polymerase 2 is responsible for the bilk of the nucleotide ploymerization
After receiving a sample of cells, you determine that the cells contain tus. What can you conclude about these cells?
they are prokaryotes
they might be cancer cells
they might be stem cells
they are gametes
B and C are possible
The following are TRUE regarding DNA replication in Prokaryotes and Eukaryotes
Replication is semi-conservative
replication is bi-directional
replication uses ribosomes
replication uses promoter sequences
If a DNA molecule has 200 bp then it is--------long
3.4 nm
6.8 Angstroms
68 nm
20 nm
According to Chargaff's rules if a DNA molecule contains 34% C, then which of the following is true?
Total pyrimidines is 50%
22% are adenine
the four bases are present at 25%
the total purines is 44%
The origins of replication in eukaryotes are called ------ and one would expect to find------
Pribnow box/ A and T bases
OriC/ DnaA, DnaB and DnaC
Shine-Delgarno/ start codon
ARS/ histones
all of the above
Telomerase extends the 3' single stranded DNA overhand in replication
The difference in transcription between eukaryotes and prokaryotes are:
one uses DNA pol 1 2 and 3 and the other uses different DNA pol enzymes
one uses primase and the other does not
one uses chromatin remodeling complexes and the other does not
one always transbries both the sense and antisense strand of the gene while the other does not
The core promoter in prokaryotes is called
kozak sequence
OriC
Pribnow box
rut sequence
operator sequence
Transcription termination in prokaryotes sometimes requires:
rho, rut and tus
stem loop, telomeres and Nus A
term sigma factor and RNA pol 2
RNA pol3 and specific transcription factors
Which is the sense strand?
In the diagram, the following are true
What is an example of a ribozyme?
rRNA
tRNA
intronic RNA
miRNA
Enhancer sequences usually bind activators and they are transcribed
in prokaryotes the small ribosomal subunit is----while in the eukaryotes it is-----
20S, 40S
20S, 50S
30S, 40S
30S, 50S
70S, 80S
Some of the rRNAs in prokaryotes are ---- while some of the rRNAs in eukaryotes are -----
16S rRNA and 18S rRNA / 23S rRNA and 28S rRNA
16S rRNA and 5S rRNA / 18S rRNA and 28S rRNA
23S rRNA and 28S rRNA / 16S rRNA and 28S rRNA
18S rRNA and 5S rRNA / 29S rRNA and 38S rRNA
Some of the steps in 5' capping of mRNA involve:
removing RNA and adding GMP
Removing DNA and adding ATP
Adding DNA and transfering a methyl group
removing a phosphate and adding GMP
adding poly A
In eukaryotes, tRNA ------
undergoes RNA processing
has unusual bases
is transported out of the cytoplasm
has codon sequences
three of the above
In prokaryotic translation, the first charged tRNA enters into the ribosomal P site and carries the amino acid fmet.
Which of the following amino acids exhibits " degeneracy" in the genetic code that CAN be explained by the "Wobble Hypothesis" alone?
The best description of isoaccepting tRNA molecules is
different anticodons but same amino acids
different codons but same amino acids
different anticodons and different amino acids
different codons and different amino acids
Choose the following answers: A. Kozak sequence B. the A site in the ribosome C. release factors D. uncharged tRNA E. none of the answers are correct
Is important in binding to 18S rRNA
Occupies the E site in translation
A possible mechanism of action of an antibiotic could be:
inhibition of DNA pol (any greek letter)
inhibition of DNA gyrase
inhibition prokaryotic peptidyl transferase
inhibition of movement of RNA out to cytoplasm
two of the answers are correct
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