Matthew Coulson
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Wednesdays 2 lectures in 1 quiz.

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Matthew Coulson
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Anticoagulant and Antiplatelet Drugs

Question 1 of 26

1

Which of the following are the body's natural anticoagulants?

Select one or more of the following:

  • Protein C

  • Protein S

  • Protein A

  • Protein G

  • Protein M

  • Antithrombin

  • Antifibrin

  • Antiprothrombinase

  • Antithrombase

  • Antithrombomodulin

Explanation

Question 2 of 26

1

Fill the blank space to complete the text.

is an anticoagulant drug which binds to one of the body's naturally occurring anticoagulants and up-regulates its action

Explanation

Question 3 of 26

1

Fill the blank space to complete the text.

Which naturally occurring anticoagulant of the body does Heparin bind to and potentiate?

Explanation

Question 4 of 26

1

Which two coagulation factors can be inhibited by unfractioned Heparin bound to antithrombin?

Select one or more of the following:

  • Factor Ia (Fibrin)

  • Factor IIa (Thrombin)

  • Factor IIIa

  • Factor IVa

  • Factor Va

  • Factor VIa

  • Factor VIIa

  • Factor VIIIa

  • Factor IXa

  • Factor Xa

Explanation

Question 5 of 26

1

The difference between unfractioned Heparin and LMWH is that LMWH can only bind to one clotting factor, which is...

Select one of the following:

  • Factor Ia

  • Factor IIa

  • Factor IIIa

  • Factor IVa

  • Factor Va

  • Factor VIa

  • Factor VIIa

  • Factor VIIIa

  • Factor IXa

  • Factor Xa

Explanation

Question 6 of 26

1

Which monitoring test should be used to measure the action of unfractioned Heparin?

Select one of the following:

  • Prothrombin time

  • Activated Partial Thromboplastin Time (APTT)

  • Anti-Xa Assay

Explanation

Question 7 of 26

1

Heparin can induce thrombocytopenia with thrombosis in long term use.

Select one of the following:

  • True
  • False

Explanation

Question 8 of 26

1

Which of the following complications can be caused by long term Heparin use?

Select one of the following:

  • Osteoporosis

  • Hypothyroidism

  • Iron Deficiency Anaemia

  • B12 Deficiency Anaemia

  • Acute Myeloid Leukaemia

Explanation

Question 9 of 26

1

Whilst Heparin reversal is usually conducted by simply stopping the heparin (short half life), in cases of major bleeding which drug can be given to reverse the antithrombin effect of heparin?

Select one of the following:

  • Protamine Sulphate

  • IV Ferrous Fibrinase

  • Prothrombin Inducing Enzyme (PTIE)

  • Coagulating Factor III (CFIII)

Explanation

Question 10 of 26

1

Fill the blank space to complete the text.

Warfarin is an anticoagulant which brings about the inhibition of

Explanation

Question 11 of 26

1

Which clotting factors rely on Vitamin K for carboxylation?

Select one or more of the following:

  • Factor II

  • Factor III

  • Factor IV

  • Factor V

  • Factor VI

  • Factor VII

  • Factor VIII

  • Factor IX

  • Factor X

  • Factor I

Explanation

Question 12 of 26

1

Warfarin administration should be conducted at the same time every day.

Select one of the following:

  • True
  • False

Explanation

Question 13 of 26

1

Fill the blank space to complete the text.

Which testing method is used to measure the amount of Warfarin in an individual's system? (use acronym)

Explanation

Question 14 of 26

1

A normal INR is typically between

Select one of the following:

  • 2.0-3.0

  • 1.0-3.0

  • 3.0-4.0

  • 3.0-5.0

Explanation

Question 15 of 26

1

Which two of the following should be given to a patient with suspect Warfarin toxicity?

Select one or more of the following:

  • Vitamin K orally

  • Vitamin K intravenously

  • FFP

  • Protamine Sulphate

  • Platelet transfusion

Explanation

Question 16 of 26

1

Rivaroxaban & Apixaban are direct inhibitors of which clotting factor?

Select one or more of the following:

  • Factor Ia

  • Factor IIa

  • Factor IIIa

  • Factor IVa

  • Factor Va

  • Factor VIa

  • Factor VIIa

  • Factor VIIIa

  • Factor IXa

  • Factor Xa

Explanation

Question 17 of 26

1

Dabigatran is another type of new anticoagulant, providing direct inhibition of ...

Select one of the following:

  • Prothrombinase

  • Thrombin

  • Prothrombin

  • Fibrinogen

  • Fibrin

  • Factor VIIIa

Explanation

Question 18 of 26

1

In prophylaxis of elective hip/knee replacement surgery, which would be the most appropriate choice of medication?

Select one of the following:

  • Warfarin

  • LMWH

  • Apixaban

Explanation

Question 19 of 26

1

Structure of an artery from deep to superficial:
Tunica Intima =
Tunica Media =
Tunica Externa =
Serosa =

Drag and drop to complete the text.

    Endothelial Cells
    Smooth Muscle
    Loose Fibrous Connective Tissue
    Epithelial Cells

Explanation

Question 20 of 26

1

Fill the blank spaces to complete the text.

Atherosclerosis is damage to the endothelium resulting in plaque formation due to recruitment of 'foamy' which are rich in

Explanation

Question 21 of 26

1

Which four of the following are risk factors for arterial thrombosis?

Select one or more of the following:

  • Diabetes

  • Hypertension

  • Smoking

  • High HDL cholesterol

  • High LDL cholesterol

  • Atrial Fibrillation

  • Alcoholism

  • Hyperthryoidism

Explanation

Question 22 of 26

1

Select from the dropdown lists to complete the text.

When there is endothelial damage, platelets bind to the subendothelial collagen via ( Glycoprotein 1b, Platelet Membrane Glycoprotein, ITGA2B, Human Platelet Antigen ) and ( Von Willebrand Factor, Platelet Adhesin, Platelet Derived Growth Factor, Protein Disulfide Isomerase )

Explanation

Question 23 of 26

1

Select from the dropdown list to complete the text.

After binding to the subendothelial collagen, platelets begin to attach to each other via ( Glycoprotein IIb/IIIa, Glycoprotein Ib, Platelet Derived Growth Factor ) and fibrinogen

Explanation

Question 24 of 26

1

Antiplatelet drugs:
Clopidogrel =
Aspirin =

Drag and drop to complete the text.

    Cyclo-Oxygenase Inhibitor
    ADP receptor Antagonist

Explanation

Question 25 of 26

1

Select from the dropdown lists to complete the text.

Antiplatelets such as Abciximab inhibit ( Glycoprotein IIb/IIIa, Glycoprotein Ib, ADP ) thus inhibiting the ( aggregation, adhesion, activation ) stage of platelet plug formation

Explanation

Question 26 of 26

1

Fill the blank space to complete the text.

Antiplatelet agents should be stopped days prior to an elective operation.

Explanation

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