Matthew Coulson
Quiz by , created more than 1 year ago

Chronic Myeloid Leukaemia, Polycythaemia Rubra Vera, Essential Thrombocythaemia and Idiopathic Myelofibrosis

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Matthew Coulson
Created by Matthew Coulson over 5 years ago
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Myeloproliferative Disorders

Question 1 of 20

1

Fill the blank space to complete the text.

Philadelphia Chromosome is most associated with which form of Leukaemia?

Explanation

Question 2 of 20

1

Chronic Myeloid Leukaemia is fatal without stem cell/bone marrow transplantation in the chronic phase

Select one of the following:

  • True
  • False

Explanation

Question 3 of 20

1

Which of the following conditions can in some cases present as Gout?

Select one of the following:

  • Acute Myeloid Leukaemia

  • Acute Lymphoblastic Leukaemia

  • Chronic Lymphoblastic Leukaemia

  • Chronic Myeloid Leukaemia

Explanation

Question 4 of 20

1

Which of the following would describe findings fitting with a diagnosis of Chronic Myeloid Leukaemia?

Select one of the following:

  • Neutrophilia, Eosinophilia, Basophilia, Thrombocytosis

  • Neutropenia, Eosinopenia, Basopenia, Thrombocytopenia

Explanation

Question 5 of 20

1

- Causes a drastic rise in erythrocytes, platelets, neutrophils, etc
- Causes a drastic fall in erythrocytes, platelets, neutrophils, etc

Drag and drop to complete the text.

    Acute Myeloid Leukaemia
    Chronic Myeloid Leukaemia

Explanation

Question 6 of 20

1

Philadelphia Chromosome causes expression of a new gene encoding a protein kinase. Which of the following protein kinase inhibitors can be used to successfully treat Chronic Myeloid Leukaemia?

Select one of the following:

  • Tyrosine Kinase Inhibitors

  • Protein Kinase A Inhibitors

  • Protein Kinase G Inhibitors

  • Protein Kinase C Inhibitors

  • Tyramine Kinase Inhibitors

Explanation

Question 7 of 20

1

Fill the blank space to complete the text.

The main tyrosine kinase inhibitor used to treat chronic myeloid leukaemia is called

Explanation

Question 8 of 20

1

Fill the blank space to complete the text.

A patient presents to their GP complaining of headache, fatigue and an intense itching which only ever occurs whilst in the bath or shower. Their blood results show high haemoglobin levels accompanied by erythrocytosis (increase in circulating RBCs). What is your working diagnosis?

Explanation

Question 9 of 20

1

Fill the blank space to complete the text.

The presence of a JAK2 mutation in a patient would immediately lead you to thinking of which Myeloproliferative disorder?

Explanation

Question 10 of 20

1

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The main treatment for polycythaemia rubra vera is regular

Explanation

Question 11 of 20

1

Select from the dropdown list to complete the text.

The treatment for Polycythaemia Rubra Vera is venesection until the haematocrit falls below ( 0.45, 0.55, 0.65, 0.35 )

Explanation

Question 12 of 20

1

Fill the blank space to complete the text.

An uncontrolled production of abnormal platelets is known as Essential

Explanation

Question 13 of 20

1

Essential Thrombocythaemia causes excessive bleeding problems

Select one of the following:

  • True
  • False

Explanation

Question 14 of 20

1

Teardrop-shaped Red Blood Cells in the peripheral blood is characteristic of which Myeloproliferative Disorder?

Select one of the following:

  • Idiopathic Myelofibrosis

  • Essential Thrombocythaemia

  • Polycythaemia Rubra Vera

Explanation

Question 15 of 20

1

Fill the blank space to complete the text.

Idiopathic is a condition in which the proliferation of an abnormal clone of a hematopoietic stem cell results in fibrosis, or the replacement of bone marrow with scar tissue

Explanation

Question 16 of 20

1

Myelofibrosis typically results in hepatomegaly

Select one of the following:

  • True
  • False

Explanation

Question 17 of 20

1

What is the first line treatment for essential thrombocythaemia?

Select one of the following:

  • Interferon Gamma

  • Interferon Beta

  • Hydroxycarbamide

  • Aspirin

  • Clopidogrel

Explanation

Question 18 of 20

1

Which of the following can be used as a secondary therapy for Essential Thrombocythaemia?

Select one of the following:

  • Interferon Gamma

  • Interferon Alpha

  • Interferon Beta

Explanation

Question 19 of 20

1

Chronic Haemolysis predisposes an individual to gallstones

Select one of the following:

  • True
  • False

Explanation

Question 20 of 20

1

Fill the blank space to complete the text.

Chronic haemolysis predisposes to gallstones as there are raised levels of in the blood

Explanation

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