L4 Sympathetic nervous system and adrenergic neurotransmission

Question 1 of 10

1

Acetylcholine is the neurotransmitter at all ganglia, sympathetic or parasympathetic, and acts at nicotinic (N1) receptors.

Select one of the following:

True
False

Explanation

Question 2 of 10

1

Most sympathetic post ganglionic nerve endings have ❌ receptors (adrenoceptors), which come in 2 types, ❌. There are subtypes ❌ for both alpha and beta receptors.
Catecholamines act on several R types. Noradrenaline acts on ❌. Adrenaline acts on ❌.

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adrenergic

alpha and beta

1 and 2

alpha 1 and beta 1 receptors

all adrenergic receptors

Explanation

Question 3 of 10

1

Select all the systems on which catecholamines have inhibitory actions.

Select one or more of the following:

Heart
Vasculature to the skin, membranes and kidney
Salivary and sweat glands
Gut
Bronchial tree
Vasculature of the skeletal muscle

Explanation

Question 4 of 10

1

Select from the dropdown lists to complete the text.

Sympathetic affects on the heart, via ( beta 1, beta 2 ) receptor stimulation:
• ( increased, decreased ) heart rate and contractility
• ( increased, decreased ) AV node conduction
• ( increased, decreased ) cardiac output
Sympathetic affects on the lungs, via ( beta 2, beta 1 ) receptor stimulation:
• ( decreased, increased ) secretions
• ( increased, decreased ) airway diameter (relaxed bronchial muscle)
Sympathetic affects on the bladder:
• Relaxation of the detrusor muscle (via ( beta, alpha ) receptors)
• Contraction of the sphincter (via ( alpha 2, alpha 1 ) receptors)

Explanation

Question 5 of 10

1

Blood vessels express alpha, beta, dopamine, histamine, and muscarinic receptors. SNS activation releases noradrenaline, adrenaline, and dopamine.
Alpha 1 activation ❌ vessels (arterioles) and ❌ blood flow to unnecessary organs, so more blood can flow to where it's needed. Beta 2 ❌ skeletal muscle beds and decreases overall vascular ❌, increasing ❌ to muscles.

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vasoconstricts

decreases

vasodilates

resistance

blood flow

Explanation

Question 6 of 10

1

Dopamine (DA) has 3 different concentration-dependent mechanisms:
- Low [DA]: acts at ❌ receptors to dilate renal ❌, and increase ❌.
- Med [DA]: stimulates ❌ receptors to dilate ❌, and decreases systemic vascular ❌
- High [DA]: stimulates ❌ receptors to cause vessel constriction and increase ❌.

All levels of dopamine ❌ kidney perfusion.

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dopamine 1

kidney perfusion

artery

beta 2

skeletal muscle bed

resistance.

alpha 1

blood pressure

increase

Explanation

Question 7 of 10

1

Which of these is not a side effect of drugs that activate the SNS?

Select one of the following:

Decrease motility of large intestine, can cause constipation
Cause pupillary dilation (may cause blurred vision)
Cause piloerection (goose bumps)
Cause perspiration (sweating)
Cause dry mouth (may cause dysphagia)

Explanation

Question 8 of 10

1

Sympathomimetic drugs are drugs that mimic the action of the ❌ nervous system and are adrenergic ❌. They can be ❌ acting, and therefore selective for specific adrenergic receptors(or non-selective). They can also be ❌ acting, by increasing the availability of ❌ to stimulate adrenoceptors.

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agonists

sympathetic

direct

indirect

noradrenaline/adrenaline

Explanation

Question 9 of 10

1

Entacapone and selegine are directly acting sympathomimetic drugs used to treat Parkinson's disease.

Select one of the following:

True
False

Explanation

Question 10 of 10

1

Adrenergic ❌ are sympatholytics, i.e. they break the effects of the SNS. Many drugs ❌ with the function of the SNS, and affect the ❌ of sympathetically innervated organs. Several of these are important for the treatment of ❌ diseases(e.g. Beta blockers such as ❌.)

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antagonists

interfere

physiology

cardiovascular

metoprolol

	Created by Mer Scott over 5 years ago

PHCY310 Quiz on L4 Sympathetic nervous system and adrenergic neurotransmission, created by Mer Scott on 02/04/2019.

L4 Sympathetic nervous system and adrenergic neurotransmission

Question 1 of 10

Acetylcholine is the neurotransmitter at all ganglia, sympathetic or parasympathetic, and acts at nicotinic (N1) receptors.

Select one of the following:

Explanation

Question 2 of 10

Most sympathetic post ganglionic nerve endings have ❌ receptors (adrenoceptors), which come in 2 types, ❌. There are subtypes ❌ for both alpha and beta receptors. Catecholamines act on several R types. Noradrenaline acts on ❌. Adrenaline acts on ❌.

Drag and drop to complete the text.

Explanation

Question 3 of 10

Select all the systems on which catecholamines have inhibitory actions.

Select one or more of the following:

Explanation

Question 4 of 10

Select from the dropdown lists to complete the text.

Explanation

Question 5 of 10

Drag and drop to complete the text.

Explanation

Question 6 of 10

Drag and drop to complete the text.

Explanation

Question 7 of 10

Which of these is not a side effect of drugs that activate the SNS?

Select one of the following:

Explanation

Question 8 of 10

Sympathomimetic drugs are drugs that mimic the action of the ❌ nervous system and are adrenergic ❌. They can be ❌ acting, and therefore selective for specific adrenergic receptors(or non-selective). They can also be ❌ acting, by increasing the availability of ❌ to stimulate adrenoceptors.

Drag and drop to complete the text.

Explanation

Question 9 of 10

Entacapone and selegine are directly acting sympathomimetic drugs used to treat Parkinson's disease.

Select one of the following:

Explanation

Question 10 of 10

Adrenergic ❌ are sympatholytics, i.e. they break the effects of the SNS. Many drugs ❌ with the function of the SNS, and affect the ❌ of sympathetically innervated organs. Several of these are important for the treatment of ❌ diseases(e.g. Beta blockers such as ❌.)

Drag and drop to complete the text.

Explanation

Most sympathetic post ganglionic nerve endings have ❌ receptors (adrenoceptors), which come in 2 types, ❌. There are subtypes ❌ for both alpha and beta receptors.
Catecholamines act on several R types. Noradrenaline acts on ❌. Adrenaline acts on ❌.