First generation H1 antihistamines have low ❌ selectivity and high ❌ permeability. They take ❌ hours to onset of action, and last ❌ hours. They are taken ❌. Their side effects can include sedation, dry ❌, urinary ❌, increased appetite, postural ❌ or dizziness, and possibly ventricular arrythmias.
Second generation antihistamines have ❌ H1 selectivity and ❌ BBB permeability, therefore side effects are uncommon. They take ❌ hours to onset of action, and the majority of them are dosed ❌ daily, lasting for 24 hours.
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