Hussain Basheer
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Quiz on Molecular Biology MCQs, created by Hussain Basheer on 07/06/2019.

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Hussain Basheer
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Molecular Biology MCQs

Question 1 of 88

1

Which processes are parts of mRNA maturation?

Select one or more of the following:

  • splicing

  • 3´ capping

  • formation of double-stranded regions

  • polyadenylation

Explanation

Question 2 of 88

1

Down syndrome is caused by

Select one or more of the following:

  • a gene mutation

  • a structural chromosomal mutation

  • a numerical chromosomal mutation

  • a frameshift mutation

Explanation

Question 3 of 88

1

During anaphase II of meiosis

Select one or more of the following:

  • homologues separate and migrate towards
    opposite

  • sister chromatids separate and migrate
    towards opposite poles

  • nuclear membrane reforms

  • chromosomes line up in a single line

Explanation

Question 4 of 88

1

What is a promoter

Select one or more of the following:

  • it is a protein complex

  • it is a nucleotide sequence

  • it is needed for initiation of replication

  • it is crucial for transcription initiation

Explanation

Question 5 of 88

1

A primer is a short sequence of

Select one or more of the following:

  • RNA where replication starts

  • DNA where transcription starts

  • DNA where replication starts

  • RNA where translation startS

Explanation

Question 6 of 88

1

A primer is a short

Select one or more of the following:

  • protein sequence where replication starts

  • DNA sequence where transcription starts

  • RNA sequence where replication starts

  • RNA sequence where translation starts

Explanation

Question 7 of 88

1

DNA replication is

Select one or more of the following:

  • conservative

  • semiconservative

  • dispersive

  • continuous

Explanation

Question 8 of 88

1

Necrosis is

Select one or more of the following:

  • a result of acute chronic damage

  • controlled genetically

  • characterized by inflammation

  • characterized by rupture of the plasma
    membrane

Explanation

Question 9 of 88

1

The nucleosome

Select one or more of the following:

  • is DNA wrapped around a histone
    octamer

  • contains four types of histone proteins

  • is a complex of DNA and non-histone
    proteins;

  • contains five types of histone proteins

Explanation

Question 10 of 88

1

RNA Polymerase III transcribes:

Select one or more of the following:

  • mRNA;

  • 5.8S rRNA

  • tRNA

  • 5S rRNA

Explanation

Question 11 of 88

1

Synapsis occurs during

Select one or more of the following:

  • mitosis

  • anaphase I

  • prophase I

  • mitosis and meiosis

Explanation

Question 12 of 88

1

Which statements for oogenesis are true?

Select one or more of the following:

  • it is interrupted process

  • meiosis II is accomplished after
    fertilization

  • starts during puberty

  • has 4 distinct stages

Explanation

Question 13 of 88

1

Oogenesis begins

Select one or more of the following:

  • in the embryonic period

  • at birth

  • at puberty

  • in the last week of gestation

Explanation

Question 14 of 88

1

In oogenesis meiosis II is accomplished

Select one or more of the following:

  • at birth

  • after fertilization

  • before fertilization

  • at ovulation

Explanation

Question 15 of 88

1

A missense mutation

Select one or more of the following:

  • is an exchange of a coding codon with a STOP codon

  • is an exchange of a coding codon with a codon coding for another amino acid

  • a coding codon with a codon coding for the same aminoacid

  • changes the amino acid sequence of the protein

Explanation

Question 16 of 88

1

tRNA carries

Select one or more of the following:

  • The amino acid to the nucleuS

  • the rRNA to the mRNA

  • the mRNA to the nucleus

  • the amino acid to the ribosome

Explanation

Question 17 of 88

1

snRNA are localized in the

Select one or more of the following:

  • nucleus

  • cytoplasm

  • mitochondria

  • cell membrane

Explanation

Question 18 of 88

1

snRNA is used in

Select one or more of the following:

  • translation

  • splicing

  • polyadenylation

  • transcription

Explanation

Question 19 of 88

1

Helicase

Select one or more of the following:

  • separates the two DNA strands

  • elongates the newly synthesized strand

  • joins the Okazaki fragments

  • removes the supercoiling

Explanation

Question 20 of 88

1

Necrosis is characterized by

Select one or more of the following:

  • shrinkage of the cell

  • DNA ladder

  • rupture of the cell membrane

  • genetic program

Explanation

Question 21 of 88

1

In eukaryotes the first amino acid synthesized during translation is

Select one or more of the following:

  • isoleucine

  • leucine

  • methionine

  • formylmethionine

Explanation

Question 22 of 88

1

Western blotting is a method for detection of:

Select one or more of the following:

  • RNA

  • DNA

  • proteins

  • lipids

Explanation

Question 23 of 88

1

Southern blotting is a method for
detection of:

Select one or more of the following:

  • RNA

  • DNA

  • sugars

  • proteins

Explanation

Question 24 of 88

1

Northern blotting is a method for detection of

Select one or more of the following:

  • RNA

  • DNA

  • proteins

  • lipids

Explanation

Question 25 of 88

1

The nitrogen bases in the DNA helix are linked by

Select one or more of the following:

  • phosphodiester bonds

  • disulfide bridges

  • covalent bonds

  • hydrogen bonds

Explanation

Question 26 of 88

1

In metaphase of mitosis

Select one or more of the following:

  • the nucleolus breaks down

  • chromosomes are at the equator

  • the nuclear membrane reforms

  • chromosomes move to the opposite poles

Explanation

Question 27 of 88

1

Pyrimidines are

Select one or more of the following:

  • adenine and guanine

  • adenine and cytosine

  • thymine and guanine

  • thymine and cytosine

Explanation

Question 28 of 88

1

Purines are

Select one or more of the following:

  • adenine and thymine

  • thymine and guanine

  • adenine and guanine

  • thymine and cytosine

Explanation

Question 29 of 88

1

Mitochondrial DNA is

Select one or more of the following:

  • linear

  • single-stranded

  • inherited paternally

  • circular

Explanation

Question 30 of 88

1

If the mRNA has 90 codons, then the polypeptide chain is made of

Select one or more of the following:

  • 270 amino acids

  • 30 aminoacids

  • 90 amino acids

  • 60 amino acids

Explanation

Question 31 of 88

1

. mRNA

Select one or more of the following:

  • carries the amino acid to the ribosome

  • is synthesized in the cytoplasm

  • is the template for translation

  • contains rRNA genes

Explanation

Question 32 of 88

1

The acrosomal reaction

Select one or more of the following:

  • enables the entry of the sperm cell into oocyte

  • enables fusion of the male and female pronuclei

  • prevents polyspermy

  • completes meiosis II of the oocyte

Explanation

Question 33 of 88

1

The cortical reaction

Select one or more of the following:

  • enables the entry of the sperm cell into the
    oocyte

  • enables the fusion of the male and female
    pronuclei

  • prevents polyspermy

  • changes the membrane potential of the sperm cell membrane

Explanation

Question 34 of 88

1

Crossing-over occurs during

Select one or more of the following:

  • anaphase I

  • prophase I

  • mitosis

  • metaphase

Explanation

Question 35 of 88

1

Okazaki fragments form in the process of:

Select one or more of the following:

  • transcription

  • translation

  • splicing

  • replication

Explanation

Question 36 of 88

1

. A missense mutation changes the

Select one or more of the following:

  • amino acid sequence of the protein

  • open reading frame of the gene

  • order of codons within the gene

  • position of the TATA box in the promoteR

Explanation

Question 37 of 88

1

PCR is a method for amplification of

Select one or more of the following:

  • RNA

  • DNA

  • sugars

  • proteins

Explanation

Question 38 of 88

1

47 XX+21 is the genetic formula of a
female with

Select one or more of the following:

  • Turner syndrome

  • Down syndrome

  • Kleinfelter syndrome

  • Edwards syndrome

Explanation

Question 39 of 88

1

A male with a karyotype 47, XXY has

Select one or more of the following:

  • Turner syndrome

  • Kleinfelter syndrome;

  • Down syndrome

  • Edwards syndrome

Explanation

Question 40 of 88

1

A female with a karyotype 45, X0 has

Select one or more of the following:

  • Turner syndrome

  • Kleinfelter syndrome

  • Down syndrome

  • Edwards syndrome

Explanation

Question 41 of 88

1

The genetic formula 45, XO is typical of

Select one or more of the following:

  • Down syndrome

  • Kleinfelter syndrome

  • Turner syndrome

  • Edwards syndrome

Explanation

Question 42 of 88

1

Turner syndrome is

Select one or more of the following:

  • trisomy of the X chromosome

  • monosomy of the X chromosome

  • monosomy of the Y chromosome

  • trisomy of the Y chromosome

Explanation

Question 43 of 88

1

Edwards syndrome is a trisomy of chromosome

Select one or more of the following:

  • 12

  • 21

  • 23

  • 18

Explanation

Question 44 of 88

1

In proteins amino acids are linked by

Select one or more of the following:

  • peptide bonds

  • disulfide bridges

  • hydrogen bonds

  • triphosphate bridges

Explanation

Question 45 of 88

1

In anaphase of mitosis

Select one or more of the following:

  • The nucleolus breaks down

  • chromosomes are at the equator

  • the nuclear membrane reforms

  • chromosomes move to the opposite poles

Explanation

Question 46 of 88

1

In meiosis sister chromatids separate during

Select one or more of the following:

  • metaphase I

  • telophase II

  • anaphase II

  • prometaphase I

Explanation

Question 47 of 88

1

An enhancer is a

Select one or more of the following:

  • nucleotide sequence

  • protein complex

  • transcription factor

  • ribozyme

Explanation

Question 48 of 88

1

In DNA nucleotides are linked by

Select one or more of the following:

  • phosphodiester bonds

  • disulfide bridges

  • covalent bonds

  • hydrogen bonds

Explanation

Question 49 of 88

1

The functions of miRNAs are

Select one or more of the following:

  • coding

  • enzymatic

  • transporting

  • regulatory

Explanation

Question 50 of 88

1

The nitrogen bases in the DNA helix are linked by

Select one or more of the following:

  • phosphodiester bonds

  • disulfide bridges

  • covalent bonds

  • hydrogen bonds

Explanation

Question 51 of 88

1

The 5’ cap is important for

Select one or more of the following:

  • snRNA stability

  • formation of the spliceosome

  • termination of transcription

  • mRNA transport into the cytoplasm

Explanation

Question 52 of 88

1

The TATA sequence is commonly found
in:

Select one or more of the following:

  • telomeres

  • centromeres

  • promoters

  • enhancers

Explanation

Question 53 of 88

1

In meiosis sister chromatids separate
during

Select one or more of the following:

  • metaphase I

  • telophase II

  • anaphase II;

  • prometaphase I

Explanation

Question 54 of 88

1

The Robertsonian translocation is a

Select one or more of the following:

  • structural chromosomal mutation

  • gene mutation

  • point mutation

  • separation of metacentric chromosomes.

Explanation

Question 55 of 88

1

Which proteins control the cell cycle?

Select one or more of the following:

  • snRNPs

  • activators

  • CDKs

  • promoters

Explanation

Question 56 of 88

1

Polyadenylation occurs at

Select one or more of the following:

  • the 5’ end of DNA during replication

  • the 3’ end of rRNA during transcription

  • the 5’ end of mRNA during transcription

  • the 3’ end of mRNA during transcription

Explanation

Question 57 of 88

1

The spliceosome contains

Select one or more of the following:

  • transcription factors

  • endonucleases

  • snRNPs

  • enhancers

Explanation

Question 58 of 88

1

Capacitation is a reaction that occurs in

Select one or more of the following:

  • oogenesis

  • spermatogenesis

  • fertilization

  • meiosis

Explanation

Question 59 of 88

1

The START codon for translation is

Select one or more of the following:

  • AAU

  • AUU

  • AUG

  • AUC

Explanation

Question 60 of 88

1

How many types of rRNA exist in
eukaryotes?

Select one or more of the following:

  • 1

  • 2

  • 3

  • 4

Explanation

Question 61 of 88

1

DNA replication takes place during

Select one or more of the following:

  • S phase

  • G1 phase

  • metaphase

  • telophase

Explanation

Question 62 of 88

1

Prokaryotic mRNA

Select one or more of the following:

  • is monocistronic

  • contains introns;

  • has a 5’ cap

  • has more than one cistron

Explanation

Question 63 of 88

1

Heterochromatin

Select one or more of the following:

  • contains functional genes

  • is decondensed

  • replicates late in the S phase

  • is lightly stained

Explanation

Question 64 of 88

1

Euchromatin

Select one or more of the following:

  • is darkly stained

  • is replicated late in the S phase

  • contains functional genes

  • is highly condensed

Explanation

Question 65 of 88

1

Apoptosis

Select one or more of the following:

  • causes inflammation

  • is under genetic control

  • is caused by rupture of the cell membrane

  • causes enlargement of the cell

Explanation

Question 66 of 88

1

Which enzymes promote apoptosis?

Select one or more of the following:

  • snRNPs

  • topoisomerases

  • polymerases

  • caspases

Explanation

Question 67 of 88

1

Intron is the

Select one or more of the following:

  • coding region of a gene

  • non-coding region of a gene

  • 2 nucleotides that code for one amino acid

  • 3 nucleotides that code for one amino acid

Explanation

Question 68 of 88

1

Exon is the:

Select one or more of the following:

  • coding region of a gene

  • non-coding region of a gene

  • 2 nucleotides that code for one amino acid

  • 3 nucleotides that code for one amino acid

Explanation

Question 69 of 88

1

Spermatogenesis

Select one or more of the following:

  • is an interrupted process

  • begins at birth

  • has 4 distinct stages

  • is very inefficient

Explanation

Question 70 of 88

1

The consequence of a nonsense mutation
is

Select one or more of the following:

  • change in the amino acid sequence

  • truncated protein

  • shift of the open reading frame

  • different codon order

Explanation

Question 71 of 88

1

The first AUG sequence in eukaryotes is
located in the

Select one or more of the following:

  • Shine-Dalgarno sequence

  • Kozak sequence

  • Pribnow box

  • TATA box

Explanation

Question 72 of 88

1

Kozak sequence

Select one or more of the following:

  • tRNA

  • mRNA

  • rRNA

  • snRNA

Explanation

Question 73 of 88

1

Which method is used for DNA
amplification?

Select one or more of the following:

  • Southern blot

  • Northern blot

  • PCR

  • RT-PCR

Explanation

Question 74 of 88

1

Which enzyme is not involved in DNA
replication?

Select one or more of the following:

  • RNA polymerase

  • ligase

  • RNA primase

  • telomerase

Explanation

Question 75 of 88

1

The acrosome is:

Select one or more of the following:

  • an organelle at the tip of the sperm cell

  • the site where the flagellum of the sperm
    cell begins

  • an organelle in the perivitelline space of
    the oocyte

  • the vitelline envelope of the sperm cell

Explanation

Question 76 of 88

1

The polypeptide chain is built up of

Select one or more of the following:

  • fatty acids

  • amino acids

  • disaccharides

  • polysaccharides

Explanation

Question 77 of 88

1

In oogenesis meiosis II is accomplished

Select one or more of the following:

  • at birth

  • after fertilization

  • before fertilization

  • at ovulation

Explanation

Question 78 of 88

1

The nucleosome

Select one or more of the following:

  • Contains H2A, H2B, H3, H4 histone
    molecules;

  • contains 2 types of histone molecules

  • is DNA wrapped around a non-histone
    octamer

  • contains 6 types of histone molecules

Explanation

Question 79 of 88

1

The ribosome is a complex of

Select one or more of the following:

  • DNA and proteins

  • mRNA and tRNA

  • rRNA and polysaccharides

  • rRNA and proteins

Explanation

Question 80 of 88

1

Restriction enzymes are used in

Select one or more of the following:

  • DNA replication

  • DNA cloning

  • RNA replication

  • RNA restriction

Explanation

Question 81 of 88

1

Which nucleic acid functions as a
ribozyme?

Select one or more of the following:

  • mRNA

  • DNA

  • rRNA

  • ssDNA

Explanation

Question 82 of 88

1

Plasmids are circular DNAs in

Select one or more of the following:

  • mammalian cells

  • viruses

  • bacterial cells

  • sperm cells

Explanation

Question 83 of 88

1

. The nucleosome contains

Select one or more of the following:

  • an octamer of histones and 246 bp of DNA

  • an octamer of histones and 146 bp of DNA

  • a hexamer of histones and 146 bp of DNA

  • a hexamer of histones and 146 bp of RNA

Explanation

Question 84 of 88

1

SSB proteins are required for

Select one or more of the following:

  • transcription

  • translation

  • splicing

  • replication

Explanation

Question 85 of 88

1

Which enzyme does not take part in DNA
replication?

Select one or more of the following:

  • helicase

  • ligase

  • RNA primase

  • RNA polymerase

Explanation

Question 86 of 88

1

Which enzyme unwinds DNA?

Select one or more of the following:

  • DNA-polymerase

  • helicase

  • transferase

  • topoisomerase

Explanation

Question 87 of 88

1

What is the sequence of the mRNA, if the DNA antisense strand is
AATCCGGAT?

Select one or more of the following:

  • 5’ ATCCGGATT 3’

  • 5’ TTAGGCCTA 3’

  • 5’ AUCCGGAUU 3’

  • 5’ UUAGGCCUA 3’

Explanation

Question 88 of 88

1

Topoisomerase

Select one or more of the following:

  • removes supercoiling of DNA

  • separates the two DNA strands

  • destroys the nuclear envelope

  • forms the peptide bond

Explanation

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