blood clotting
requires Ca2+
is promoted by erythrocytes
defects usually shorten the bleeding time
is initiated by tissue tromboplastin in the intrinsic coagulation pathway
is decreased by platelets
B- lymphocytes
secrete circulating antibodies
carry antigen receptors on their surface
secrete antigens
a+b
b+c
red blood cells
measure 15mm in diameter
do not contain mitochondria
have a life span in circulation of 30 days
are released from the bone marrow as mature cells
contain nucleus
the following is true about the ABO and Rh systems
a person of group O is a universal recipient
a person who is group AB has anti-A and anti-B antibodies
the presence of D antigen means that the subject is Rh (+)
Rh antibodies occur naturally
the person of group A has anti-A antibodies
which of the following helps in blood clotting
vit B1
vit B2
vit D
vit K
vit B6
the function of haemoglobin is
transport of oxygen
destruction of bacteria
prevention of anaemia
utilisation of energy
transport of CO
which of the following substances is an anticoagulant
Ca 2+
heparin
fibrinogen
albumin
gama-globulins
what are the agglutinins
antibodies
antigens
beta-globulins
amino acids
lipids
which of the following substances influences indirectly blood clotting
calcium ions
mineralocorticoids
renin
for which of the following cells phagocytosis is not typical
neutrophils
plasmocytes
monocytes
eosinophils
macrophages
normal (physiological) hemolysis takes place
inside the heart
inside the spleen and liver
inside the kidneys
inside the big blood vessels
inside the bone marrow
which of the following are functions of the blood
transport
regulation
protection
temperature regulations
all of the above
the blood volume of an average size male is
3-4l
4-5l
5-6l
6-7l
7-9l
the blood volume is
10-12 % body weight
10L
6-8% body weight
5L
3-5% body weight
the effects on plasma volume of 500ml blood loss are neutralised within
1-2 hours
8-10 hours
24 hours
one week
one month
antithrombin III affects which coagulation factor
XIIa
Xa
IIa
IXa
vitamin K neutralizes
factor 5
antithrombin 3
plasminogen
none of the above
platelet activation will not occur without
Ca2+
vessel wall damage
von Willebrand factor
serotonin
hematocrit of 0.45 means that in the sample of blood analysed
0.45% Hb is in the plasma
0.45% of total blood volume is made up of plasma
0.45% of Hb is in the RBC
0.45% of the total blood volume is made up of RBCs and WBCs
0.45% of blood volume is made of Tr
which of the following statements concerning the monocyte is incorrect
more common in blood than eosinophils and basophils
produced in the adult by the bone marrow and lymph nodes
unlike neutrophil does not accumulate outside circulation in area of inflammation
not classified as a granulocyte
2-8% of differential blood count
hemoglobin contains
one protoporphyrin ring and four ferrous ions
four protoporphyrin ring and one ferrous ions
four protoporphyrin rings and four ferrous ions
one protoprophyrin ring and one ferrous ion
which blood component plays the biggest role in maintaining the osmotic pressure of blood
carbon dioxide
white blood cells
globulins
in a normal blood sample, which of the following cells will be the most abundant
basophils
lymphocytes
an antigen is
a chemical messenger that is released by virus infected cells
a lymphocyte responsible for cell-mediated immunity
something that coats the inside of lungs, causing infection
a protein or other molecule that is recognised as non-self
a thick yellow-white fluid
where is the site of maturation for a B cell
thymus
bone marrow
pancreas
cortex
spleen
nonspecific resistance is
the bodys ability to ward off diseases
the bodys defenses against any kind of pathogen
the bodys defense against a particular pathogen
the lack of resistance
non of the above
which gland shrinks in size during adulthood, and has hormones that function in the maturation of T lymphocytes
lymph nodes
pineal gland
tonsils
the rate of erythrocyte sedimentation is increased when
the plasma albumin fraction is increased
fibrinogen in the blood is decreased
the plasma globulin fraction is decreased
the plasma globulin fraction is increased
lack of erythropoietin
agglutinins are found in
the erythrocyte membrane
the leukocytes
the plasma
the platelets
gamma- globulins are related to
humoral immunity
blood coagulation
transport of gases by the blood
erythropoiesis
cellular immunity
oxyhaemoglobin is a compound of
hemoglobin and O2
hemoglobin and CO2
hemoglobin and Fe2+
hemoglobin and CO
hemoglobin and N
the amount of plasma proteins is
135-145mmol/l
140-160g/l
50-83 g/l
2.8-5.6 mmol/l
0.4-0.5 l/l
the plasma of blood type AB contains
anti-A agglutinins
anti-B agglutinins
anti-A and anti-B agglutinins
no agglutinins
agglutinogens A and B
osmotic hemolysisis due to
water hypotonic solution entering the erythrocytes
destruction of the erythrocyte membrane by chemicals
fibrinolysis
formation of carbaminohemoglobin
transformation of fibrinogen into fibrin
hypervolemia is
increased blood volume
decreased blood volume
increased blood cholesterol
increased plasma proteins
increased blood pressure
leucopenia is
increased number of leukocytes
increased number of platelets
decreased number of leukocytes
increased number of erythrocytes
decreased number of platelets
when AB(0) blood is transfused to a recipient of blood type 0 (anti-A, anti-B)
the limit of the blood transfused is up to 300ml
the transfused amount is unlimited
transfusion is forbidden
transfusion of plasma is the only possibility
possible only once in a lifetime
sodium citrate stops coagulation by
blocking fibrinogen
reacting with Ca2+
massive fibrinolysis
destruction of platelets
blocking vit K
the normal RBC count in men is
140-160.10/l
4.5-6.0.10/l
4-11.10/l
200-400.10/l
0.4-0.5/l
leukocytosis
increased number of platelet
increased percentage of neutrophils
platelets take part in
the immune defense
the transport of gases in blood
hemostasis
rennin-angiontensin-aldosterone system
hemoglobin concentration in men is
4-5.2.10/l
160 +/- g/l
140-160g%
of major significance for maintaining the blood oncotic pressure is
the number of erythrocytes
the plasma globulin fraction
the leukocyte count
the plasma albumin fraction
the plasma fibrinogen
the red colour of blood is due to
the plasma cholesterol
Ca2+ and K+ in plasma
the granules in the leukocytes
the hemoglobin in the erythrocytes
the normal blood platelet count is
4.4-5.2.10/l
60-90.10/l
140-400.10/l
formation of the white plug
formation of the red plug
fibrin clot destruction
viscose metamorphosis of the platelets
destruction of adrenal medulla
when blood transfused from 0 (anti-A and anti-B) donor to AB (0) recipient
the amount is up to 500 ml
amount is unlimited
transfusion is impossible
only plasma may be transfused
only once in an lifetime
the osmotic fragility is determined by the use of
hypotonic solution of NaCl
hypertonic solution of NaCl
HCl
NaOH
celloscope
heparin is
a factor transforming prothrombin into thrombin
platelet factor 8
endogenic anticoagulant
exogenic anticoagulant
pancreatic enzyme
the plasma protein fraction of major significance for coagulation is
globulin
gamma-globulin
globulin and albumin
the ESR (westergren) reterence values are
men up to 50 <15mm/h
140-160 g/l
women above 50-5-10mm.h
men above 50-3-8mm.h
of major significance for the erythrocyte sedminentation rate is
the albumin/globulin ratio
total blood cholesterol
the platelet count
the leukocytes ratio (%)
the normal leukocyte count is
200-400.10.l
3.5-10.5.10.l
4.5-5.2.10.l
60-90.10.l
20-40% of all blood cells
Fe2+ ions are necessary for
the production of fibrinogen
the formation of leukocytes
the formation of platelets
the synthesis of thyrecalcitonin
the percentage of Rh(+) people is
15%
85%
50%
30%
15% of pregnant women
hematocrit reference range in women is
140-160g.l
2.4-2.6mmol.l
0.55-1.48mmol.l
0.36-0.47 l.l
4.5-10.l
hematocrit measure the percentage of
white blood cells volume
plasma volume
platelets volume
red blood cells volume
serum proteins volume
to prevent blood loss after a tissue injury, blood vessels first
form a platelet plug
form a clot
initiate the coagulation cascade
constrict and form barriers
dilate
a foreign substance, usually a protein, that stimulates the immune system to react by producing antibodies is called
allergen
antigen
histamine
mast cell
interferon
when neutrophils and macrophages squeeze out of capillaries to fight off infection it is called
phagocytosis
hemolysis
interleukins
diapedesis
folliculitis
each of the following is a components of plasma except
water
proteins
formed elements
nutrients
salts
extracellular fluid in adults differs from intracellular fluid in that its
volume is greater
tonicity is lower
Na+ concentration is lower
sodium:potassium molar ratio is higher
pH is lower
total body water, expressed as a percentage of body weight
can be measured with an indicator dilution technique using deuterium oxide
is small on average in women than in men
rises following injection of posterior pituitary extracts
is less than 80% in young adults
breakdown of erythrocytes in the body
occurs when they are 6-8 weeks old
is named erythropoiesis
yields iron, most of which is excreted in the urine
yields bilirubin which is carried by plasma protein to the liver
is required for the synthesis of bile salts
a person with group A blood
has anti-A antibody in the plasma
may have the genotype AB
may have a parent with group 0 blood
may have children with group A or group 0 blood only
whose partner is also A can only have children of group A
the spleen destroys
healthy RBC
damaged RBC
plasma bilirubin
is a steroid pigment
is converted to biliverdin in the liver
does not normally cross cerebral capillary walls
is freely filtered in the renal glomerulus
has red colour
originate from precursors in the lymph nodes
can increase in number when their parent cells are stimulated by factors released from activated lymphocytes
unlike granulocytes do not migrate across capillary walls
take part in haemostasis
manufacture immunoglobulin M
erythrocytes
are responsible for the major part of blood viscosity
contain the enzyme carbonic anhydrase
metabolize glucose to produce CO2 to H2O
carry O2 and CO2
human plasma albumin
contributes more to plasma colloid osmotic pressure than globulin
can not filter freely at the glomerulus
is negatively charged at the normal pH of blood
carries sex hormones in blood
neutrophil granulocytes
are the most common leukocyte in normal blood
contain proteolytic enzymes
contain actin and myosin microfilaments
are present in high concentration in pus
bleeding from a small cut in the skin
is normally diminished by local vascular spasm
ceases within about 5 minutes in normal people
is greater from warm skin than from cold skin
is reduced if the affected limb is elevated
circulating red blood cells
are about 1% nucleated
take part in immunity
are distributed evenly across the blood stream in large blood vessels
deform as they pass through the capillaries
travel at a slower velocity in venules than in capillaries
are motile
can transform into plasma cells
increase in number during infection
decrease in number during immunosuppressive drug therapy
blood
makes up about 3% of body weight
forms a higher percentage of body weight in fat than in thin people
squeezes out serum when it clots
volume can be calculated by multiplying plasma volume by the haematocrit (expressed as a percentage)
volume rises after diuretic is taken
the pH
of arterial blood normally ranges from 7.2-7.6
units express [H+] in moles/litre
of blood is directly proportional to the pCO2
of blood is directly proportional to [HCO3]
of arterial blood is lower than venous blood
blood eosinophils
have agranular cytoplasm
are about a quarter of all leukocytes
are relatively abundant in the mucosa of the respiratory, urinary and alimentary tracts
are 50-70% of all leukocytes
increase in number in viral infections
lymph
doesnt contain plasma protiens
vessels are involved in the absorption of amino acids from the intestine
production decreases during muscular activity
does not normally contain cells
flow is aided by contraction of adjacent skeletal muscles
blood platelets
are formed in bone marrow
are normally more numerous than white cells
increase in number after injury and surgery
alter shape when in contact with collagen
an appropriate dilution indicator for measuring
total body water is sucrose
plasma volume is radioactive sodium
extracellular fluid volume is inulin
intracellular fluid volume directly is heavy water
total body water is radioactive iodine
ceases within about five minutes in normal people
is greater from warm skin than form cold skin
travel at slower velocity in venules than in capillaries
forms a higher percentage of body weigh in fat than in thin people
units express [H+] in moles/ litre
of blood is directly proportional to pCO2
of blood is directly proportional to [HCO3-]
doesnt contain plasma proteins
flow is aided by concentration of adjacent skeletal muscles
are formed in the bone marrow
extracellular fluid volume is insulin
intracellular fluid volume directly is heavy water (deuterium oxide)
excessive tissue fluid (oedema) in the legs may
be associated with a raised extracellular fluid volume
results from hepatic disease
result from blockage of pelvic lymphatics
increase local interstitial fluid pressure
haemolytic disease of the newborn
can be perverted by injecting the mother with antiD agglutinins just after delivery
affects mainly babies of Rh positive mothers
occurs mainly in babies who lack D agglutinogen
causes jaundice which clears rapidly after birth
can be treated by transfusing the affected baby with Rh positive blood
patients with moderate severe anaemia have a reduced
cardiac output
incidence of vascular bruits
2:3 diphosphoglycerate blood level
arterial pO2
capacity to raise oxygen consumption in exercise
iron deficiency
frequently follows persistent loss of blood from the body
is more common in men than in women
may cause anaemia by inhibiting the rate of multiplications of RBC stem cells
may cause large pale erythrocytes to appear in peripheral blood
anaemia should normally be treated by injections of iron
severe reactions are likely after transfusion of blood gorups
A to a group B person
0 to a group AB person
0 to a group A person
A to a group AB person
0 Rh negative to a group AB Rh positive person
the haematocrit (packed cell volume)
may be obtained by centrifugation of blood
may be calculated by multiplying the mean cell volume by the red cell count
rises in a patient who sustains widespread burns
rises following vomiting
red cell formation is increased
in blood donors one week after a blood donation
in patients with a hemolytic anaemia
by giving injections of erythropoietin to nephrectomized patients
in patients who have a raised blood reticulocyte count
hematocrit reference range in men is
0.4-0.54l/l
2.4-2.6 mmol/l
0.55-1.48 mmol/l
4.5-1012/l
red blood cells would swell in which type of solution
hypotonic
isotonic
hypertonic
hydrophilic
lipophilic
the most abundant type of protein in plasma is
insulin
glycogen
the number of oxygen molecules carried by one Hb molecule
1
2
4
8
6
majority of clotting factors are produced in
liver
kidney
heart
brain
muscle
cellular immunity is due to
B lymphocytes
T lymphocytes
action of plasmin is
to remove calcium
antithrombin action
to stimulate heparin
to degenerate fibrin
to produce plug
which is the most rare blood group
A (Rh+)
AB (Rh+)
AB (Rh-)
B (Rh-)
0 (Rh+)
the hemoglobin level in women is
4-5.2x1012/l
140 +- 20g/l
140-160 g%
the number of RBC in women is
140-160.109/l
0.4-0.5.l
4-11.109.l
200-400.109.l
3.9-5.3.1012.l
the ESR (westergren) reference values are
women above 50-5-10 mm.h
140-160 g.l
women up to 50: <20mm.h
men up to 50:3-8mm.h
carbhemoglobin is a compound of
hemoglobin with carbon dioxide
hemoglobin with oxygen
hemoglobin with carbon monoxyde
hemoglobin with nitrogen
hemoglobin with Fe3
in the WBC defferntial count the neutrophilic band cells are
0-6%
0-2%
42-70%
22-48%
1-14%
in the WBC differential count the basophil granulocytes are
in the WBC defferential count the eosinophil granulocytes are
in the WBC defferential count the lymphocytes are
in the WBC differential count the monocytes are
bleeding time is
1-12ng.ml
2-5min
11-14s
2.0-4.5g.l
136-151mmol.l
which hormones reduced erythropoiesis
androgens
growth hormones
glucocorticoids
estrogens
erythropoietin
erythropoiesis stimulating factors are
vitB12 and folic acid
iron
testosterone
the valency of iron in the hem group is
1+
2+
3+
4+
5+
anemia is
reduced hemoglobin level
reduced RBC count
reduced RBC count and/or hemoglobin level
hyperhemoglobinemia
the plasma of blood type A contains
aglutinins alpha and beta
aglutinins alpha
aglutinins beta
no aglutinins
aglutinogen A
the plasma of blood type B contains
aglutinogen B
the plasma of blood type 0 contains
aglutnins beta
aglutinogens A and B
the lymphatic system is one of the main pathways for the absorption of
carbohydrates
micronutrients