Protein trafficking

Question 1 of 16

1

Which trafficking pathway is highlighted in the picture?

Select one of the following:

Biosynthetic pathway
Endocytic pathway
Secretory pathway
Nuclear export pathway

Explanation

Question 2 of 16

1

The depicted trafficking pathway is regulated by cellular signals.

Select one of the following:

True
False

Explanation

Question 3 of 16

1

Which experiment is a genetic approach to characterize the components and the molecular mechanism of the endomembrane system?

Select one of the following:

Cell-free systems
Live-cell imaging
Pulse-chase labelling
Mutant phenotype analysis

Explanation

Question 4 of 16

1

Which experiments make use of microsomes to study the endomembrane system?

Select one or more of the following:

Pulse-chase labelling
Cell-free systems
Subcellular fractionation
Live-cell imaging

Explanation

Question 5 of 16

1

Which is the organelle with the largest surface area?

Select one of the following:

Golgi
Endoplasmic reticulum
Plasma membrane
Nucleus

Explanation

Question 6 of 16

1

The signal sequence is a short stretch of ❌ amino acids at the ❌ of a nascent protein that serves as an ❌ signal.

Drag and drop to complete the text.

hydrophobic

hydrophilic

N-terminus

C-terminus

ER-targeting

nuclear export

Golgi-targeting

Explanation

Question 7 of 16

1

Fill the blank space to complete the text.

SRP stands for "".

Explanation

Question 8 of 16

1

Which of the following is a multi-protein complex with an hour-glass shaped aqueous pore?

Select one of the following:

NPC
Sec61
SRP
Proteosome

Explanation

Question 9 of 16

1

Fill the blank space to complete the text.

TMD stands for "".

Explanation

Question 10 of 16

1

Fill the blank space to complete the text.

TMD is a short stretch of hydrophobic amino acids which serves as a .

Explanation

Question 11 of 16

1

Fill the blank space to complete the text.

UPR () initiates pathways that lead to either the production of more chaperone protein or a global reduction in protein synthesis to alleviate ER stress.

Explanation

Question 12 of 16

1

Fill the blank spaces to complete the text.

The process in which misfolded proteins are shuttled out of the ER to the where the oligosaccharide chain is removed and the protein is degraded in the is called ().

Explanation

Question 13 of 16

1

During core modification of a glycoprotein, the last remaining glucose is removed by

Select one of the following:

Glycosidase I
Glycosidase II
Glycosidase III
Calnexin

Explanation

Question 14 of 16

1

Select from the dropdown lists to complete the text.

UGGT is an ER chaperone which recognizes ( hydrophobic, negatively charged, hydrophilic ) regions of misfolded proteins and tags them for refolding by adding back a ( glucose, fatty acid ) molecule.

Explanation

Question 15 of 16

1

In the endomembrane system, the new membrane can only arise from the existing membrane.

Select one of the following:

True
False

Explanation

Question 16 of 16

1

According to current knowledge, which of the following are not components of the endomembrane system?

Select one or more of the following:

Nucleus
Golgi
ER
Lysosome
Endosome
Clathrin-coated vesicle
Mitochondria

	Created by Chau Tran about 5 years ago

Quiz on Protein trafficking, created by Chau Tran on 17/11/2019.

Protein trafficking

Question 1 of 16

Which trafficking pathway is highlighted in the picture?

Select one of the following:

Explanation

Question 2 of 16

The depicted trafficking pathway is regulated by cellular signals.

Select one of the following:

Explanation

Question 3 of 16

Which experiment is a genetic approach to characterize the components and the molecular mechanism of the endomembrane system?

Select one of the following:

Explanation

Question 4 of 16

Which experiments make use of microsomes to study the endomembrane system?

Select one or more of the following:

Explanation

Question 5 of 16

Which is the organelle with the largest surface area?

Select one of the following:

Explanation

Question 6 of 16

The signal sequence is a short stretch of ❌ amino acids at the ❌ of a nascent protein that serves as an ❌ signal.

Drag and drop to complete the text.

Explanation

Question 7 of 16

Fill the blank space to complete the text.

SRP stands for "".

Explanation

Question 8 of 16

Which of the following is a multi-protein complex with an hour-glass shaped aqueous pore?

Select one of the following:

Explanation

Question 9 of 16

Fill the blank space to complete the text.

TMD stands for "".

Explanation

Question 10 of 16

Fill the blank space to complete the text.

TMD is a short stretch of hydrophobic amino acids which serves as a .

Explanation

Question 11 of 16

Fill the blank space to complete the text.

UPR () initiates pathways that lead to either the production of more chaperone protein or a global reduction in protein synthesis to alleviate ER stress.

Explanation

Question 12 of 16

Fill the blank spaces to complete the text.

The process in which misfolded proteins are shuttled out of the ER to the where the oligosaccharide chain is removed and the protein is degraded in the is called ().

Explanation

Question 13 of 16

During core modification of a glycoprotein, the last remaining glucose is removed by

Select one of the following:

Explanation

Question 14 of 16

Select from the dropdown lists to complete the text.

UGGT is an ER chaperone which recognizes hydrophobic negatively charged hydrophilic( hydrophobic, negatively charged, hydrophilic ) regions of misfolded proteins and tags them for refolding by adding back a glucose fatty acid( glucose, fatty acid ) molecule.

Explanation

Question 15 of 16

In the endomembrane system, the new membrane can only arise from the existing membrane.

Select one of the following:

Explanation

Question 16 of 16

According to current knowledge, which of the following are not components of the endomembrane system?

Select one or more of the following:

Explanation

UGGT is an ER chaperone which recognizes ( hydrophobic, negatively charged, hydrophilic ) regions of misfolded proteins and tags them for refolding by adding back a ( glucose, fatty acid ) molecule.