Fill the blank spaces to complete the text.
Fill in the blanks below to describe the process of endochronal ossification.
1. A bone forms around the cartilage model. This occurs when the perichondreum is vascularised, supplying nutrients which allow the cells to differentiate into which gather at the diaphysis wall.
2. within the central cavity enlarge, causing the matrix to . This matrix is then impermeable to nutrients causing the cells within to . This forms a cavity supported by the bone collar.
3. The invades the cavity. forming spongy bone.
4. break down new spongy bone to form the cavity. The ossification centres appear at the .
5. Once ossification of the epiphyses is complete, hyaline cartilage remains only at the epihyseal and the surfaces.