Inflammation and Wound Healing - L6-7

Question 1 of 24

1

Fill the blank space to complete the text.

How do you describe an organ that is inflamed?

= inflammation of that tissue

Explanation

Question 2 of 24

1

Acute Inflammation

Select one or more of the following:

mediated by Interleukin-1 and other cytokines
Systemic response to severe injury or inflammation
To over come the cause of Inflammation (occurring after the other type of inflammation fails)
Walls off area with fibrous connective tissue

Explanation

Question 3 of 24

1

Chronic Inflammation

Select one or more of the following:

Walls off the area with fibrous connective tissue
Mediated by Interleukin-1 and other cytokines
Systemic response to severe injury or inflammation
To over come the cause of Inflammation (occurring after the other type of inflammation fails)

Explanation

Question 4 of 24

1

Fill the blank spaces to complete the text.

What are the five classical signs associated with Inflammation?
1.
2.
3.
4.
5.

Explanation

Question 5 of 24

1

Changes occurring during the vascular phase of acute inflammation

1. ❌
Capillary beds ❌
Signs associated: ❌ and ❌

2. ❌
Chemical mediators are released ❌
Fluid flows through the ❌
Signs associated: ❌

3. ❌
Blood is more ❌ - ❌ the flow
Increase in ❌ and ❌ in the area

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Vasodilation of arterioles

Contraction of endothelial cells

Leakage of Fluid

viscous

Heat

Redness

gaps into the extracellular space

Swelling

Slows

RBC

WBC

causing contraction of endothelial cells

distend with blood

Explanation

Question 6 of 24

1

Fill the blank spaces to complete the text.

Functions of the vascular phase

1.
2.
3.
4.

Explanation

Question 7 of 24

1

Changes occurring during the cellular phase of inflammation

1. ❌
Slowing of blood during the vascular phase - leukocytes contact endothelial cells

2. ❌
2a. ❌
2b. ❌
2c. ❌ and ❌
2d. ❌
2e. ❌

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Margination

Emigration

Tethering

Rolling

Activation

firm adhesion

Transmigration

Chemotaxis

Explanation

Question 8 of 24

1

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Functions of the cellular phase

1.
2.
3. to
4.

Explanation

Question 9 of 24

1

Fill the blank spaces to complete the text.

What are the Leukocytes associated with inflammation?

1.
2.
3.

Explanation

Question 10 of 24

1

What are the four different inflammatory exudates?

1. ❌ exudate
❌, low in ❌

2. ❌ Inflammation
Fibrinogen --> ❌
❌ present

3. ❌ Inflammation
Mucus
Due to inflammation of ❌

4. ❌ or ❌ Inflammation
❌
Lot of ❌, ❌ and ❌

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Serous

Watery fluid

protein

clots

Neutrophils

Catarrhal

mucous membranes

Suppurative

Purulent

Pus

neutrophils

fluid

necrotic debris

Fibrinous

Explanation

Question 11 of 24

1

Fill the blank spaces to complete the text.

What is the purpose of inflammatory mediators?

Be the that , or inflammation

Explanation

Question 12 of 24

1

Demolition Phase

What: The ❌ after the fluid and cellular phases

Processes occurring: ❌ and ❌

Processes function: To ❌

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breakdown and removal of necrotic tissue

Liquefaction

Phagocytosis

prepare for repair and regeneration

Explanation

Question 13 of 24

1

Fill the blank spaces to complete the text.

What are the outcomes of acute inflammation?

1.
If injury is and there is
Damage is or

2.
OR occurs when there is lots of tissue destruction or they cant regenerate

3.
If the cause of OR
Something

Explanation

Question 14 of 24

1

Four phases of wound healing

1. ❌
AIM: ❌ ❌
❌ --> ❌ --> ❌

2. ❌
❌ present
❌ remove ❌

3. ❌ & ❌
AIM: ❌
❌ produce ❌ --> ❌ of epi. cells and fibroblasts
Granulation tissue = ❌

4. ❌
Once inflammation finished & new tissue forms - ❌ ❌

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Homeostasis

Acute Inflammation

Granulation tissue formation

replacement of epithelial tissue cells

Wound maturation and Remodeling

To prevent further bleeding

by blood clotting

Vessel constriction

Platelet plug

Fibrin plug

Classical signs of inflammation

Neutrophils and Macrophages

debris from injury

Fill in gap of damaged tissue

fibrous connective tissue + capillaries

granulation tissue is replaced by mature

connective tissue

macrophages

growth factors

proliferation

Explanation

Question 15 of 24

1

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Healing by First Intention
+

Occurs if:
Minimal
Minimal

Explanation

Question 16 of 24

1

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Healing by second intention
- , ,

Occurs when:
Greater

Wound edges
present

Explanation

Question 17 of 24

1

Process of wound contraction
Feature of ❌
Wound margins ❌

- ❌ ❌
- ❌ ❌
- Continues ❌

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2nd Intention

grow towards each other

Myofibroblasts at edges contract

bringing edges together

Makes smaller wound to fill with

granulation tissue and epithelial cells

after re-epithelialisation

Explanation

Question 18 of 24

1

Fill the blank spaces to complete the text.

Factors affecting wound healing

1.
2.
3.
4.
5.
6.

Explanation

Question 19 of 24

1

Fill the blank spaces to complete the text.

What are the events involved in fracture repair?
1.
2.
3.
4.

Explanation

Question 20 of 24

1

Fill the blank spaces to complete the text.

What are the factors that affect fracture healing?

1.
2.
3.

Explanation

Question 21 of 24

1

Fill the blank spaces to complete the text.

Antigen:
substance that or

Antibody:
in response to or

Explanation

Question 22 of 24

1

Hypersensitivity reactions P1

Type I = ❌ Hypersensitivity
Due to ❌
Occurs within ❌
Reactions directed against ❌
activation of ❌, ❌ & ❌
Mediators that cause: ❌, ❌ --> ❌, ❌

E.g ❌ (Hay fever)

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Immediate

IgE antibodies

minutes of repeat exposure

seconds of repeat exposure

antigens from enviro & parasites

mast cells

basophils

eosinophils

smooth muscle spasm

oedema

swelling

excessive mucus secretion

Allergic Rhinitis

Rhinitis Allergic

Explanation

Question 23 of 24

1

Hypersensitivity reactions P2

Type II = ❌ hypersensitivity
Formation of ❌ of the ❌
Leads to the ❌

E.g. ❌

Type III = ❌ hypersensitiviity
Occurs due to ❌ ❌
These ❌
Neutrophils release ❌ into tissue - damage tissue
commonly occurs in the ❌, ❌, ❌ and ❌

E.g. ❌ (SLE)

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Antibody mediated

Immune complex

Immune mediated haemolytic anaemia

Lupus

antibodies directed against antigens

surface of a cell or tissue

cell being destroyed

formation of antigen-antibody complexes

in bloodstream

get stuck in capillaries

toxic free radicals and enzymes

joints

glomeruli

eye

blood vessels

Explanation

Question 24 of 24

1

	Created by Hannah-Marie Rhodes over 4 years ago

Pathology Quiz on Inflammation and Wound Healing - L6-7, created by Hannah-Marie Rhodes on 12/02/2020.

Inflammation and Wound Healing - L6-7

Question 1 of 24

Fill the blank space to complete the text.

How do you describe an organ that is inflamed? = inflammation of that tissue

Explanation

Question 2 of 24

Acute Inflammation

Select one or more of the following:

Explanation

Question 3 of 24

Chronic Inflammation

Select one or more of the following:

Explanation

Question 4 of 24

Fill the blank spaces to complete the text.

What are the five classical signs associated with Inflammation? 1. 2. 3. 4. 5.

Explanation

Question 5 of 24

Changes occurring during the vascular phase of acute inflammation 1. ❌ Capillary beds ❌ Signs associated: ❌ and ❌ 2. ❌ Chemical mediators are released ❌ Fluid flows through the ❌ Signs associated: ❌ 3. ❌ Blood is more ❌ - ❌ the flow Increase in ❌ and ❌ in the area

Drag and drop to complete the text.

Explanation

Question 6 of 24

Fill the blank spaces to complete the text.

Functions of the vascular phase 1. 2. 3. 4.

Explanation

Question 7 of 24

Changes occurring during the cellular phase of inflammation 1. ❌ Slowing of blood during the vascular phase - leukocytes contact endothelial cells 2. ❌ 2a. ❌ 2b. ❌ 2c. ❌ and ❌ 2d. ❌ 2e. ❌

Drag and drop to complete the text.

Explanation

Question 8 of 24

Fill the blank spaces to complete the text.

Functions of the cellular phase 1. 2. 3. to 4.

Explanation

Question 9 of 24

Fill the blank spaces to complete the text.

What are the Leukocytes associated with inflammation? 1. 2. 3.

Explanation

Question 10 of 24

What are the four different inflammatory exudates? 1. ❌ exudate ❌, low in ❌ 2. ❌ Inflammation Fibrinogen --> ❌ ❌ present 3. ❌ Inflammation Mucus Due to inflammation of ❌ 4. ❌ or ❌ Inflammation ❌ Lot of ❌, ❌ and ❌

Drag and drop to complete the text.

Explanation

Question 11 of 24

Fill the blank spaces to complete the text.

What is the purpose of inflammatory mediators? Be the that , or inflammation

Explanation

Question 12 of 24

Demolition Phase What: The ❌ after the fluid and cellular phases Processes occurring: ❌ and ❌ Processes function: To ❌

Drag and drop to complete the text.

Explanation

Question 13 of 24

Fill the blank spaces to complete the text.

What are the outcomes of acute inflammation? 1. If injury is and there is Damage is or 2. OR occurs when there is lots of tissue destruction or they cant regenerate 3. If the cause of OR Something

Explanation

Question 14 of 24

Four phases of wound healing 1. ❌ AIM: ❌ ❌ ❌ --> ❌ --> ❌ 2. ❌ ❌ present ❌ remove ❌ 3. ❌ & ❌ AIM: ❌ ❌ produce ❌ --> ❌ of epi. cells and fibroblasts Granulation tissue = ❌ 4. ❌ Once inflammation finished & new tissue forms - ❌ ❌

Drag and drop to complete the text.

Explanation

Question 15 of 24

Fill the blank spaces to complete the text.

Healing by First Intention + Occurs if: Minimal Minimal

Explanation

Question 16 of 24

Fill the blank spaces to complete the text.

Healing by second intention - , , Occurs when: Greater Wound edges present

Explanation

Question 17 of 24

Process of wound contraction Feature of ❌ Wound margins ❌ - ❌ ❌ - ❌ ❌ - Continues ❌

Drag and drop to complete the text.

Explanation

Question 18 of 24

Fill the blank spaces to complete the text.

Factors affecting wound healing 1. 2. 3. 4. 5. 6.

Explanation

Question 19 of 24

Fill the blank spaces to complete the text.

What are the events involved in fracture repair? 1. 2. 3. 4.

Explanation

Question 20 of 24

Fill the blank spaces to complete the text.

How do you describe an organ that is inflamed?

= inflammation of that tissue

What are the five classical signs associated with Inflammation?
1.
2.
3.
4.
5.

Changes occurring during the vascular phase of acute inflammation

1. ❌
Capillary beds ❌
Signs associated: ❌ and ❌

2. ❌
Chemical mediators are released ❌
Fluid flows through the ❌
Signs associated: ❌

3. ❌
Blood is more ❌ - ❌ the flow
Increase in ❌ and ❌ in the area

Functions of the vascular phase

1.
2.
3.
4.

Changes occurring during the cellular phase of inflammation

1. ❌
Slowing of blood during the vascular phase - leukocytes contact endothelial cells

2. ❌
2a. ❌
2b. ❌
2c. ❌ and ❌
2d. ❌
2e. ❌

Functions of the cellular phase

1.
2.
3. to
4.

What are the Leukocytes associated with inflammation?

1.
2.
3.

What are the four different inflammatory exudates?

1. ❌ exudate
❌, low in ❌

2. ❌ Inflammation
Fibrinogen --> ❌
❌ present

3. ❌ Inflammation
Mucus
Due to inflammation of ❌

4. ❌ or ❌ Inflammation
❌
Lot of ❌, ❌ and ❌

What is the purpose of inflammatory mediators?

Be the that , or inflammation

Demolition Phase

What: The ❌ after the fluid and cellular phases

Processes occurring: ❌ and ❌

Processes function: To ❌

What are the outcomes of acute inflammation?

1.
If injury is and there is
Damage is or

2.
OR occurs when there is lots of tissue destruction or they cant regenerate

3.
If the cause of OR
Something

Four phases of wound healing

1. ❌
AIM: ❌ ❌
❌ --> ❌ --> ❌

2. ❌
❌ present
❌ remove ❌

3. ❌ & ❌
AIM: ❌
❌ produce ❌ --> ❌ of epi. cells and fibroblasts
Granulation tissue = ❌

4. ❌
Once inflammation finished & new tissue forms - ❌ ❌

Healing by First Intention
+

Occurs if:
Minimal
Minimal

Healing by second intention
- , ,

Occurs when:
Greater

Wound edges
present

Process of wound contraction
Feature of ❌
Wound margins ❌

- ❌ ❌
- ❌ ❌
- Continues ❌

Factors affecting wound healing

1.
2.
3.
4.
5.
6.

What are the events involved in fracture repair?
1.
2.
3.
4.

What are the factors that affect fracture healing?

1.
2.
3.

Antigen:
substance that or

Antibody:
in response to or

Hypersensitivity reactions P1

Type I = ❌ Hypersensitivity
Due to ❌
Occurs within ❌
Reactions directed against ❌
activation of ❌, ❌ & ❌
Mediators that cause: ❌, ❌ --> ❌, ❌

E.g ❌ (Hay fever)

Hypersensitivity reactions P2

Type II = ❌ hypersensitivity
Formation of ❌ of the ❌
Leads to the ❌

E.g. ❌

Type III = ❌ hypersensitiviity
Occurs due to ❌ ❌
These ❌
Neutrophils release ❌ into tissue - damage tissue
commonly occurs in the ❌, ❌, ❌ and ❌

E.g. ❌ (SLE)

Immunological Test
Measures - checks the
E.g.

Serological Test
Based on the ability to detect reactions from the
E.g. S