Loading [MathJax]/jax/output/HTML-CSS/fonts/TeX/fontdata.js
vikki.hodge
Mind Map by , created more than 1 year ago

Medical Microbiology Mind Map on Antibiotic Targets and modes, created by vikki.hodge on 18/09/2013.

113
2
0
vikki.hodge
Created by vikki.hodge over 11 years ago
Rate this resource by clicking on the stars below:
1 2 3 4 5 (0)
Ratings (0)
0
0
0
0
0

0 comments

There are no comments, be the first and leave one below:

Close
Antibiotic Targets andmodesAct on the Cell Wallrelatively inexpensiveTarget RibosomesInhibit Nucleic Acid SynthesisAnti-metabolitesnon-toxic (can be administered in high doses)Penicillincontains bete-Lactam ring.beta-lactam inhibits the cross link between peptidoglycanbetween NAM and NAG in the bacterial cell wallthe bete-lactam ring binds with the enzymethat produces these linkagesthe enzyme that hydrolisesthese bonds continue to workmaking the cell wall weak, theosmotic pressure will continueto rise eventually causing thecell to burst and dieusually on gram positive as there is a single cell wallBlocks the division of the bacteriaSulfonamidesinhibit the production of folic acid an important metabolitein DNA synthesis therefor cells are unable to dividehumans require folic acid but the get it through diet andwe do not synthesis it therefor this is effective againstorganismis that rely on folic acid synthesisselective toxicitycompetitive inhibition ofdihydropterate synthetase (DHPS)DHPS catalyses tconversion of PABA todihydropterate in folate synthesis pathwayinhibits the use of a metabolite which is part of normal metabolismcan have a toxic effect on cells such as haltgrowth and cell division (sometimes used incancer treatments)Streptomycincannot be administered orally but insteadby regular intramuscular injectionstargets protein synthesisbinds to the 30s subunits of the bacterialribosome, this misleads the DNA codoneventually causing inhibition of proteinsynthesisby binding to the 30s subunit it interferes with the 50s subunit whcih associates withmRNA. as a result an unstable mRNA strand is produced meaning the incorect AAacids are coded for and therefore the worn proteing are produced causing cell deathcan be used on both gran negativeand positive making it a broadspectrum antibioticbacterial ribosomes are different than that ofhumans meaning that it has specific toxicityQunilonesbroad spectrumprevent DNA from unwinding and duplicatingtargets DNA gyrasa (topoisomerase) which causesthe DNA to unwind during DNA replication.used to treat certain infections (UTIs) caused by gram negative bacteriaenter cells via pores therefore oftenused to treat intracellular infectionsDouble click this nodeto edit the textClick and drag this buttonto create a new node