Eleanor garvey
Quiz by , created more than 1 year ago

Test II: 25, 27, 29, 59, 64, 66, 96, 100, 107, 109, 111, 121, 122, 123, 126, 133, 137, 141, 143, 145, 147

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Eleanor garvey
Created by Eleanor garvey over 4 years ago
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Psychopharmacology Test 2

Question 1 of 21

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Test 2 Question 25. Which one of the following statements is true regarding atypical antipsychotics?

Select one of the following:

  • Ziprasidone is an agonist at the serotonin (5-HT) 1A receptor and an inhibitor of reuptake of both serotonin and norepinephrine

  • Risperidone is a significantly weaker antagonist of the dopamine D2 receptor than haloperidol

  • Quetiapine is known for its high incidence of extrapyramidal symptoms

  • Olanzapine has been associated with weight loss in the majority of patients

  • Clozapine has been shown to increase suicidality in chronically ill patients

Explanation

Question 2 of 21

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Test 2 Question 27. Which of the following is not a side effect of the tricyclic antidepressants?

Select one of the following:

  • Tachycardia

  • Prolonged PR interval

  • Prolonged QRS interval

  • Orthostatic hypotension

  • Diarrhea

Explanation

Question 3 of 21

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Test 2 Question 29. Which one of the following antidepressants can be used as an antipruritic agent and for the treatment of gastric ulcer
because of its potent histamine blockade?

Select one of the following:

  • Trazodone

  • Fluoxetine

  • Citalopram

  • Amitriptyline

  • Amoxapine

Explanation

Question 4 of 21

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Test 2 Question 59. Which of the following is not a tricyclic antidepressant?

Select one of the following:

  • Amitriptyline

  • Amoxapine

  • Doxepin

  • Desipramine

  • Nortriptyline

Explanation

Question 5 of 21

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Test 2 Question 64. Carbamazepine will not lower the levels or the efficacy of which one of the following agents?

Select one of the following:

  • Warfarin

  • Clozapine

  • Alprazolam

  • Propranolol

  • Citalopram

Explanation

Question 6 of 21

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Test 2 Question 66. Patients who smoke tobacco heavily can markedly reduce levels of psychotropic medications they are taking. Which one of the following medications is not affected by tobacco smoking in this way?

Select one of the following:

  • Clozapine

  • Olanzapine

  • Haloperidol

  • Risperidone

  • Amitriptyline

Explanation

Question 7 of 21

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Test 2 Question 96. Buspirone’s mechanism of action is predominantly linked to which one of the following receptors?

Select one of the following:

  • Serotonin 2A

  • Serotonin 1A

  • N-methyl-d-aspartate (NMDA)

  • Dopamine 2

  • NE

Explanation

Question 8 of 21

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Test 2 Question 100. Which one of the following agents is least likely to exacerbate the extrapyramidal symptoms of Parkinson’s disease?

Select one of the following:

  • Amoxapine

  • Perphenazine

  • Thorazine

  • Fluphenazine

  • Phenelzine

Explanation

Question 9 of 21

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Test 2 Question 107. Which one of the following tricyclic antidepressants is not considered a tertiary amine?

Select one of the following:

  • Imipramine

  • Amitriptyline

  • Desipramine

  • Clomipramine

  • Trimipramine

Explanation

Question 10 of 21

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Test 2 Question 109. The metabolite of which one of the following tricyclic antidepressants has potent dopamine-blocking ability that can lead to antipsychotic-like side effects?

Select one of the following:

  • Amoxapine

  • Clomipramine

  • Desipramine

  • Trimipramine

  • Imipramine

Explanation

Question 11 of 21

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Test 2 Question 111. Interaction with the enzyme cytochrome P450 (CYP) 2D6 has what bearing on the use of tricyclic antidepressants?

Select one of the following:

  • None; tricyclics do not interact with CYP 2D6

  • Those with decreased CYP 2D6 activity will have lower than expected plasma drug concentrations

  • Giving a patient on a tricyclic a CYP 2D6 inhibitor could cause a drop in the plasma concentration of the drug

  • Cimetidine can cause an increase in tricyclic levels as a result of its interaction with CYP 2D6

  • Concomitant use of drugs that inhibit CYP 2D6 with tricyclics may necessitate higher than usual prescribed doses of either drug to obtain the same levels

Explanation

Question 12 of 21

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Test 2 Question 121. Which one of the tricyclic antidepressants has the most antihistaminic activity?

Select one of the following:

  • Amoxapine

  • Clomipramine

  • Desipramine

  • Nortriptyline

  • Doxepin

Explanation

Question 13 of 21

1

Test 2 Question 122. Which one of the following is not helpful in the treatment of obsessive–compulsive disorder?

Select one of the following:

  • Bupropion

  • Fluvoxamine

  • Clomipramine

  • Sertraline

  • Fluoxetine

Explanation

Question 14 of 21

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Test 2 Question 123. Which one of the following is true regarding the tricyclic antidepressants?

Select one of the following:

  • The downregulation of β-adrenergic receptors correlates most closely with time needed for clinical improvement in
    patients

  • Giving tricyclics leads to an increase in β-adrenergic receptors

  • Giving tricyclics leads to an increase in 5-HT receptors

  • Giving tricyclics leads to an increase in β-adrenergic receptors and a decrease in 5-HT receptors

  • Giving tricyclics leads to a decrease in β-adrenergic receptors and an increase in 5-HT receptors

Explanation

Question 15 of 21

1

Test 2 Question 126. Patients with which one of the following disorders may have clinically significant side effects from tricyclic antidepressant drugs?

Select one of the following:

  • Insomnia

  • Benign prostatic hypertrophy

  • Migraine

  • Parkinson’s disease

  • Pituitary adenoma

Explanation

Question 16 of 21

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Test 2 Question 133. Which one of the following is among the least sedating of the tricyclic antidepressants?

Select one of the following:

  • Desipramine

  • Amitriptyline

  • Trimipramine

  • Doxepin

  • Imipramine

Explanation

Question 17 of 21

1

Test 2 Question 137. Caution should be taken when prescribing which one of the following to a woman on oral contraception?

Select one of the following:

  • Risperidone

  • Valproic acid

  • Gabapentin

  • Lithium

  • Carbamazepine

Explanation

Question 18 of 21

1

Test 2 Question 141. Which one of the following is not a potential repercussion of lithium intoxication?

Select one of the following:

  • Seizure

  • Renal toxicity

  • Ataxia and coarse tremor

  • Nonspecific T-wave changes

  • . Jaundice

Explanation

Question 19 of 21

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Test 2 Question 143. Which one of the following is not true regarding use of the tricyclic antidepressants?

Select one of the following:

  • Owing to their ability to prolong cardiac conduction time their use in patients with conduction defects is contraindicated.

  • These agents should be discontinued before elective surgery because they may cause hypertensive episodes during surgery

  • Some patients who experience orthostatic hypotension may respond to the use of fludrocortisone

  • Myoclonic twitches and tremors of the tongue and upper extremities are common in some patients on tricyclics

  • Amoxapine is the least likely to cause parkinsonian symptoms of all the tricyclics

Explanation

Question 20 of 21

1

Test 2 Question 145. Which one of the following antidepressants is the most serotonin-selective of the tricyclics?

Select one of the following:

  • Amoxapine

  • Clomipramine

  • Desipramine

  • Nortriptyline

  • Doxepin

Explanation

Question 21 of 21

1

Test 2 Question 147. Which one of the following is not a side effect of treatment with tricyclic antidepressants?

Select one of the following:

  • Termination of ventricular fibrillation

  • Increased collateral blood supply to ischemic heart muscle

  • Decreased contractility

  • Tachycardia

  • Hypertension

Explanation

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