Becca Shaw
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University Physiology and Pharmacology Quiz on Drug Targets - Receptors, created by Becca Shaw on 07/05/2015.

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Becca Shaw
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Drug Targets - Receptors

Drug Targets - Receptors

Question 1 of 34

1

Drugs are evenly distributed around the body. True or false?

Select one of the following:

  • True
  • False

Explanation

Question 2 of 34

1

Irreversible binding is mainly confined to what?

Select one of the following:

  • Receptor binding sites

  • Ion channels

  • Enzyme inhibitors

  • Transport/carrier proteins

Explanation

Question 3 of 34

1

Irreversible binding uses what type of bonding?

Select one of the following:

  • Covalent

  • Hydrogen

  • Ionic

  • Van der Waals

Explanation

Question 4 of 34

1

Which of the following are examples of natural binding sites?

Select one or more of the following:

  • Receptor binding sites

  • Modulatory sites

  • Allosteric sites

  • Enzyme active sites

Explanation

Question 5 of 34

1

Modulatory or allosteric sites are a type of separate site to which drugs can bind. True or false?

Select one of the following:

  • True
  • False

Explanation

Question 6 of 34

1

Drugs that block function are known as

Select one or more of the following:

  • Antagonists at receptors

  • Inhibitors at transporters/carriers

  • Blockers at ion channels

  • Inhibitors at enymes

Explanation

Question 7 of 34

1

What is the generic name for Adrenaline?

Select one of the following:

  • Fluoxetine

  • Noradrenaline

  • Epinephrine

  • Tetracycline

Explanation

Question 8 of 34

1

What is the generic name for Aspirin?

Select one of the following:

  • Mefanamic acid

  • Epinephrine

  • Diacetylmorphine

  • Acetylsalicylic acid

Explanation

Question 9 of 34

1

What is the generic name for Heroin?

Select one of the following:

  • Fluoxetine

  • Diacetylmorphine

  • Epinephrine

  • Acetylsalicylic acid

Explanation

Question 10 of 34

1

What is the generic name for Prozac?

Select one of the following:

  • Fluoxetine

  • Diacetylmorphine

  • Acetylsalicylic acid

  • Mefanamic acid

Explanation

Question 11 of 34

1

The use of an antagonist on a receptor results in

Select one or more of the following:

  • Enzyme activition

  • Opening of ion channels

  • No effect produced

  • Blockage of endognous mediators

Explanation

Question 12 of 34

1

What direct mechanism would an agonist have on a receptor molecule?

Select one of the following:

  • Enzyme activation or inhibition

  • Opening or closing of ion channels

  • Modulation of ion channels

  • DNA transcription

Explanation

Question 13 of 34

1

What transduction mechanisms may occur due to the activity of an agonist on a receptor molecule?

Select one or more of the following:

  • Ion channel modulation

  • DNA transcription

  • Enzyme inhibition or activation

  • Opening or closing of ion channel

Explanation

Question 14 of 34

1

Proteins that bind to specific molecules, called ligands, to produce a response are known as receptors. True or false?

Select one of the following:

  • True
  • False

Explanation

Question 15 of 34

1

When drugs act through receptors, these receptors will always have exogenous ligands. True or false?

Select one of the following:

  • True
  • False

Explanation

Question 16 of 34

1

Examples of endogenous ligands are

Select one or more of the following:

  • Hormones

  • Diacetylmorphine

  • Fluoxetine

  • Neurotransmitters

Explanation

Question 17 of 34

1

The endogenous ligand is always an agonist. True or false?

Select one of the following:

  • True
  • False

Explanation

Question 18 of 34

1

In the absence of ligands, receptors have no other function. True or false?

Select one of the following:

  • True
  • False

Explanation

Question 19 of 34

1

Where are most receptors found?

Select one of the following:

  • Embedded in the plasma membrane

  • Circulating in the blood

  • Lining the epithelium of the gut

  • In the brain

Explanation

Question 20 of 34

1

Which of the following statements are true regarding antagonists?

Select one or more of the following:

  • They bind loosely to receptors

  • The produce no effect themselves

  • They prevent agonists from binding

  • The block the response

Explanation

Question 21 of 34

1

Which of the following statements is false regarding Histamine?

Select one of the following:

  • It is an endogenous agonist

  • Binds to receptors on stomach parietal cells

  • Is an exogenous agonist

  • Causes release of gastric acid

Explanation

Question 22 of 34

1

Which of the following blocks the parietal histamine receptors?

Select one of the following:

  • Fluoxetine

  • Acetylcholine

  • Epinephrine

  • Ranitidine

Explanation

Question 23 of 34

1

Histamine receptor H1 mediates which effect on the gastrointestinal tract?

Select one of the following:

  • Inflammation

  • Bile secretion

  • Smooth muscle contraction

  • Gastric acid secretion

Explanation

Question 24 of 34

1

Histamine receptor H2 mediates which effect on the gastrointestinal tract?

Select one of the following:

  • Inflammation

  • Secretion of gastric acid

  • Bile secretion

  • Smooth muscle contraction

Explanation

Question 25 of 34

1

Which anatagonist acts upon Histamine receptor H2 to prevent secretion of gastric acid?

Select one of the following:

  • Ranitidine

  • Epinephrine

  • Acetylsalicylic acid

  • Mepyramine

Explanation

Question 26 of 34

1

Which antagonist acts upon Histamine receptor H1 to prevent contraction of smooth muscle in parietal cells?

Select one of the following:

  • Epinephrine

  • Ranitidine

  • Mepyramine

  • Fluoxetine

Explanation

Question 27 of 34

1

Different receptors for the same endogenous agonist are called subtypes. True or false?

Select one of the following:

  • True
  • False

Explanation

Question 28 of 34

1

Which of the following are a type of receptor family?

Select one or more of the following:

  • Ionotropic receptors (ligand-gated ion channels)

  • Kinase-linked receptors

  • Nuclear receptor (cytoplasmic)

  • Metabotropic receptors (G-protein coupled receptors)

Explanation

Question 29 of 34

1

Which of the following statements are true concerning ionotropic receptors?

Select one or more of the following:

  • Channel formed from 3-5 subunits

  • Pore domain of each subunit forms a hydrophobic channel

  • Ligands bind to an intracellular domain

  • Ions flow selectively through the membrane

Explanation

Question 30 of 34

1

The following is typical of the mechanism of receptors incorporating ion channels: 1. Agonist binds to receptor 2. Change in ion concentration in the cell 3. Depolarisation or hyperpolarisation occurs 4. Cellular effects (response)

Select one of the following:

  • True
  • False

Explanation

Question 31 of 34

1

Nicotinic acetylcholine receptor is a part of the ionotrophic receptor family. True or false?

Select one of the following:

  • True
  • False

Explanation

Question 32 of 34

1

Which of the following statements is false regarding Metabotropic receptors? (G-protein coupled receptors)

Select one of the following:

  • Consists of a single polypeptide

  • 7 transmembrane domains

  • Domains consist of beta helices

  • Ligand binds either to extracellular domain or within transmembrane domain

Explanation

Question 33 of 34

1

Muscarinic acetylcholine receptors are in the family of metabotropic receptors. True or false?

Select one of the following:

  • True
  • False

Explanation

Question 34 of 34

1

Alpha and beta adrenoceptors are examples of the 2nd messenger effects of GCPRs. True or false?

Select one of the following:

  • True
  • False

Explanation

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