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Explain mechanism of action of warfarin
Why is there a delay in onset of activity of warfarin?
why can we see a paradoxical hypercoagulable state during the first few days of therapy?
True or False
Warfarin is administered orally and is a racemic mix of two isomers- the R isomer and the S isomer
Which of the isomers of warfarin is most potent in terms of anticoagulant effect?
True or False:
Both isomers of warfarin are extensively bound to albumin and warfarin is extensivley metabolised in liver by several enzymes
True or False:
genetic polymorphism in CYP450 enzymes can result in large inter-individual variation in dose requirements
True or False
Warfarin follows linear kinetics
True or False
Warfarin dose can be influenced by diet, drug-drug interactions and health status
How do we monitor warfarin
What advice would you give patient regarding diet and warfarin?
What drug is used to reverse the effects of warfarin?
Of the following oral anticoagulants, which requires regular routine monitoring of anticoagulant effect?
warfarin
rivaroxaban
dabigatran
Which of the following drugs is administered as a prodrug?
warfarin
rivaroxaban
dabigatran
Which of the following drugs does not have predictable pharmacokinetics?
warfarin
dabigatran
rivaroxaban
which of the oral anticoagulants has very low bioavalability (about 6%):
warfarin
rivaroxaban
dabigatran etexilate
which of the following oral anticoagulants has long onset of action?
warfarin
dabigatran
rivaroxaban
which of the following oral anticoagulants has an antidote?
warfarin
rivaroxaban
dabigatran
which of the following oral anticoagulants is most likely to be affected by patient diet?
rivaroxaban
dabigatran
warfarin
