revision material for fibrinolytics phar2102
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True or False
Fibrinolytic agents are used to lyse blood clots
which of the following is not a fibrinolytic?
enoxaparin
streptokinase
alteplase
reteplase
tenecteplase
True or False:
fibrinolytic agents can be classed as fibrin specific agents and non-fibrin specific agents
True or False
Plasma is produced when plasminogen is activated. Plasmin is a proteolytic enzyme which breaks down fibrin that provides structural support for a clot
which of the following fibrinolytics is non-fibrin specific?
alteplase
reteplase
tenecteplase
streptokinase
True or False
Fibrin specific agents produce limited plasminogen conversion in absence of fibrin
True or False
non-fibrin specific agents catalyse systemic fibrinolysis and cannot distinguish between fibrin bound palsminogen and circulating plasminogen
True or False
activaiton of circulating plasminogen by non-fibrin specific agents can produce a systemic lytic state
True or False
Fibrin specific agents are based on naturally occurring tissue plasminogen activator (tPA) which acts by binding to surface of clot and activating fibrin bound plasminogen, plasmin is cleaved from the plasminogen associated with the fibrin and the fibrin is broken apart by plasmin to dissolve clot
True or False
streptokinase is not a protease. It works by forming a complex with plasminogen which induces a conformational change in plasminogen that exposes its active site. the complex then serves as an activator of additional plasminogen molecules
What was the first fibrinolytic agent developed?
Where does streptokinase come from?
what is a disadvantage of streptokinase?
what is an example of a second generation fibrinolytic?
explain what alteplase is and how it is made
what are two examples of third generation fibrinolytics?
How does reteplase differ in chemical structure from alteplase?
How does the third generation fibrinolytic reteplase differ from alteplase in terms of half-life?
Do alteplase and reteplase have the antibody problem seen with streptokinase?
How does tenecteplase differ in chemical structure from alteplase and how is it made?
How does half-life of tenecteplase differ from alteplase and reteplase?
