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Cancer questions

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Cancer 1

Cancer 1

Question 1 of 25

1

What is the most common cancer in males?

Select one or more of the following:

  • Non Melanoma Skin Caner

  • Prostrate cancer

  • Lung cancer

  • Colorectal

Explanation

Question 2 of 25

1

What is the most common cancer in females?

Select one or more of the following:

  • Breast cancer

  • Non Melanoma Skin Cancer

  • Lung cancer

  • Colorectal cancer

Explanation

Question 3 of 25

1

How do Tobacco smoke and coal tar form cancer?

Select one or more of the following:

  • Forming aldehyde adducts

  • Forming DNA adducts

Explanation

Question 4 of 25

1

Exposure to what substances increases the liver cancer incidence?

Select one or more of the following:

  • Aflatoxin B1 and Hepatitits B

  • alcohol and tobacco

Explanation

Question 5 of 25

1

Protooncogene inheritance is classified as

Select one or more of the following:

  • Loss of function

  • Gain of function

  • Both

  • None of the above

Explanation

Question 6 of 25

1

Tumor suppressor gene inheritance is classified as?

Select one or more of the following:

  • Loss of function

  • Gain of function

  • Both

  • None of the above

Explanation

Question 7 of 25

1

In Familial cancer syndrome what is the gene that is mutated?

Select one or more of the following:

  • RET

  • MET(HGFR)

  • BCR

  • ABL

Explanation

Question 8 of 25

1

In Hereditary renal papillary carcinoma what is the gene that is mutated?

Select one or more of the following:

  • MET (HGFR)

  • RET

  • ABL

  • BCR

Explanation

Question 9 of 25

1

What is the translocation in follicular lymphoma

Select one or more of the following:

  • 14:18

  • 15:17

  • 9:22

  • 11:22

Explanation

Question 10 of 25

1

CML translocation is seen between what chromosomes?

Select one or more of the following:

  • 9:22

  • 15:17

  • 11:22

  • 14:18

Explanation

Question 11 of 25

1

What translocation is seen in Promyelocytic leukemia?

Select one or more of the following:

  • 15:17

  • 9:22

  • 11:22

  • 14:18

Explanation

Question 12 of 25

1

Translocation in Ewing's Sarcoma?

Select one or more of the following:

  • 11:22

  • 14:18

  • 15:17

  • 9:22

Explanation

Question 13 of 25

1

How does translocation cause cancer?

Select one or more of the following:

  • The novel product promotes proliferates like an oncogene

  • It makes a transcription factor that promotes proliferation

  • It makes a novel factor that inhibits apoptosis

  • None of the above

Explanation

Question 14 of 25

1

N-MYC is amplified in what tumor?

Select one or more of the following:

  • Neuroblastoma

  • Pheochromocytoma

  • Wilms tumor

Explanation

Question 15 of 25

1

In Knudson's 2 hit model what are the mechanisms for the second hit?

Select one or more of the following:

  • Loss of heterozygosity

  • Deletion

  • recombination

  • non-dysjunction

  • All of the above

Explanation

Question 16 of 25

1

Which of the following is not inherited by Autosomal Dominance?

Select one or more of the following:

  • Retinoblasotma

  • Li-Fraumeni Syndrome

  • Hereditary Breast cancer

  • Neurofibromatosis 1

  • FAP / HNPCC

  • None of the above

Explanation

Question 17 of 25

1

What are the mutations in FAP?

Select one or more of the following:

  • APC

  • BCR

  • ABL

Explanation

Question 18 of 25

1

What are the mutations in HNPCC?

Select one or more of the following:

  • MLH 1 and 3

  • MSH 2 and 6

  • PMS 1 and 2

  • All of the above

Explanation

Question 19 of 25

1

Wnt binds to Frizzled and activates dishevelled which in turn inhibits APC/Axin/GSK-3Beta

Select one of the following:

  • True
  • False

Explanation

Question 20 of 25

1

Beta Catenin is not phosphorylated so not destroyed so it accumulates and promotes proliferation

Select one of the following:

  • True
  • False

Explanation

Question 21 of 25

1

Microsatellite instability/ replication error positive is seen in HNPCC - true or false

Select one of the following:

  • True
  • False

Explanation

Question 22 of 25

1

What are the mutations that are seen in sporadic cancer?

Select one or more of the following:

  • PTEN

  • TGFBR2

  • SMAD4

  • WT1

  • All of the above

Explanation

Question 23 of 25

1

In Xeroderma Pigmentosum the most common nucleotide repair mechanism is excision endonuclease deficiency - true or false?

Select one of the following:

  • True
  • False

Explanation

Question 24 of 25

1

In Ataxia Telegectasia (ATM) mutation of what gene promotes proliferation?

Select one of the following:

  • p53

  • RB

  • myc

  • none of the above

Explanation

Question 25 of 25

1

Bloom syndrome - DNA helicase deficiency - true or flase

Select one of the following:

  • True
  • False

Explanation

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