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Cancer questions

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Cancer 2

Question 1 of 22

1

Loss of WT-1 gene results in what cancer?

Select one of the following:

  • Neuroblastoma

  • Wilms tumor

Explanation

Question 2 of 22

1

All of the following are Autosomal recessive cancer predisposition disorders except?

Select one of the following:

  • Xeroderma Pigmentosum (XP)

  • Bloom syndrome

  • Fanconi anemia

  • Ataxia Telengiectasia

  • Breast cancer associated with BRCA2

Explanation

Question 3 of 22

1

All of the following are features of fanconi anemia except

Select one of the following:

  • Pancytopenia (bone marrow failure)

  • Risk of AML

  • Upper limb skeletal abnormalities

  • DNA repair defect

  • none of the above

Explanation

Question 4 of 22

1

Glioblastoma multiforme is due to 100x expression of an miRNA true or false?

Select one of the following:

  • True
  • False

Explanation

Question 5 of 22

1

Translocation in Burkitt's lymphoma

Select one of the following:

  • 8:14

  • 9:22

  • 11:22

  • none of the above

Explanation

Question 6 of 22

1

All of the following are true statements except

Select one of the following:

  • Kaposis sarcoma caused by HHV-8

  • Non-Hodgkin lymphoma - EBV

  • Cervical cancer - HPV

  • T-Cell leukemia - HTLV-I retrovirus

  • CML - HPV

Explanation

Question 7 of 22

1

HPV oncogenes E6 & E7 act by?

Select one of the following:

  • inactivating p53 thereby activating cell proliferation

  • activating P21 Transciption

Explanation

Question 8 of 22

1

In which cells telomeres are renewed (by activation of telomerase)?

Select one of the following:

  • Germ cells

  • cancer cells

  • all of the above

  • None of the above

Explanation

Question 9 of 22

1

Replicative senescence is due to the absence of telomerase - true or false

Select one of the following:

  • True
  • False

Explanation

Question 10 of 22

1

TERC : reverse transcriptase and TERT : RNA template true or false

Select one of the following:

  • True
  • False

Explanation

Question 11 of 22

1

Upregulation of what gene upregulates telomerase

Select one of the following:

  • MYC

  • ABL

  • BCR

  • RET

Explanation

Question 12 of 22

1

Telomerase reactivation in cancer is the initiating event true or false

Select one of the following:

  • True
  • False

Explanation

Question 13 of 22

1

Telomerase reactivation in cancer is an important step in cancer progression true or false

Select one of the following:

  • True
  • False

Explanation

Question 14 of 22

1

Which of the following receptors belong to RTK family (receptor tyrosine kinases)

Select one of the following:

  • GFR

  • Insulin receptor

  • both

  • none of the above

Explanation

Question 15 of 22

1

Activated RTKs phosphorylate what effector proteins?

Select one of the following:

  • PLC

  • PI3K

  • both PLC PI3K

  • Adenylate cyclase

Explanation

Question 16 of 22

1

RTK activation -> reveals docking site for adapter protein GRB2 -> binds to SOS (RAS GEF) --> activates RAS -> activates MAPK --> activates TFs ( FOS, JUN, MYC) true or false

Select one of the following:

  • True
  • False

Explanation

Question 17 of 22

1

Her2/EGFR2 genes are amplified in 30% breast cancers true or false

Select one of the following:

  • True
  • False

Explanation

Question 18 of 22

1

RAS-Gap gene codes for neurofibromin (NF1) true or false

Select one of the following:

  • True
  • False

Explanation

Question 19 of 22

1

Estrogen receptor = Transcription factor which binds to estrogen response element enhancing transcription of cyclin D true or false

Select one of the following:

  • True
  • False

Explanation

Question 20 of 22

1

Tamoxifen is an estrogen receptor antagonist true or false

Select one of the following:

  • True
  • False

Explanation

Question 21 of 22

1

Prostate cancer occurs in the transition zone and BPH occurs primarily in the peripheral zone true or false

Select one of the following:

  • True
  • False

Explanation

Question 22 of 22

1

Flutamide and bicalutamide are androgen receptor antagonists true or false

Select one of the following:

  • True
  • False

Explanation

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