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Year 2 Quiz on Alpha 1 Adrenergic Receptor Pathway, created by gina_evans0312 on 03/11/2013.

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Alpha 1 Adrenergic Receptor Pathway

Question 1 of 15

1

Which Gprotein causes the activation Phospholipase CBeta?

Select one of the following:

  • Gq

  • Gs

  • Gi

Explanation

Question 2 of 15

1

How is Phospholipase CBeta activated?

Select one of the following:

  • By GTP binding to the alpha subunit of the Gq protein

  • By ATP binding to the alpha subunit of the Gq protein

  • By GMP binding to the alpha subunit of the Gq protein

Explanation

Question 3 of 15

1

What is broken down by phospholipase CBeta?

Select one of the following:

  • Phosphatidynositol 4,5 bisphophate

  • Phosphatidynositol 3,5 bisphophate

  • Phosphatidynositol 2,4 bisphophate

Explanation

Question 4 of 15

1

Which product of the PCbeta pathway causes the release of calcium from the ER?

Select one of the following:

  • IP3

  • Diacylglycerol

Explanation

Question 5 of 15

1

What role(s) does the released Ca perform?

Select one or more of the following:

  • Activates protein kinase C

  • Activates protein kinase B

  • Activates various Ca dependent protein kinases

Explanation

Question 6 of 15

1

What residues are phosphorylated by the protein kinases activated by this pathway?

Select one or more of the following:

  • Serine

  • Threonine

  • Tyrosine

Explanation

Question 7 of 15

1

Which subunit of Protein Kinase C contains the pseudosubstrate domain?

Select one of the following:

  • PS

  • C1A

  • C4

Explanation

Question 8 of 15

1

What is the function of subunut C1A

Select one of the following:

  • DAG binding site

  • Calcium binding site

  • Phosphatidyl serine binding site

Explanation

Question 9 of 15

1

Do Ca 2+ and phosphatidyl serine bind to subunit C2?

Select one of the following:

  • Yes

  • No

Explanation

Question 10 of 15

1

Which subunits are part of the catalytic domain?

Select one or more of the following:

  • C1A

  • C3

  • C4

  • PS

  • C5

Explanation

Question 11 of 15

1

ATP binds to C2, True or False?

Select one of the following:

  • True

  • False

Explanation

Question 12 of 15

1

When IP3 causes the increase in cytosolic calcium, what happens to protein kinase C?

Select one of the following:

  • It moves to the membrane and binds with DAG

  • It remains in the cytoplasm and binds with DAG

Explanation

Question 13 of 15

1

Once protein kinase C has bound to DAG in the membrane, what does it then bind to to release the pseudosubstrate from its active site?

Select one of the following:

  • Phosphatidylserine

  • Phosphatidylglycine

  • Phosphatidylglutamate

Explanation

Question 14 of 15

1

Which of the following is a tumor promoting agent?

Select one of the following:

  • Phorbol ester

  • Orphol ester

  • Phenyl ester

Explanation

Question 15 of 15

1

How do tumor promoting agents effect Phospholipase CBeta?

Select one of the following:

  • They bind without being degraded, so it becomes hyperactive

  • They stop the alpha subunit binding, so it becomes unreactive

  • They cause the multiplication of the number of PCbeta enzymes in the cell, causing hyperactivity

Explanation

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