PKB Activation Through RAS

When T.K is phosphorylated, which subunit of PI-3-Kinase binds first?

What allows the regulatory subunit to bind?

Name the catalytic subunit of PI-3-Kinase

When PI-3-Kinase is complete, what binds?

Role 1 of PI-3-Kinase

Part of PDK1 that allows PIP3 interaction

Where does PDK1 activation occur?

What membrane molecule does PKB bind to?

Inactive PKB Structure

Part of PKB that binds to PIP2

PKB binds to PIP2

Partial Activation caused by

Full activation caused by

PKB moves GLUT4 to membrane (T/F)

PKB causes Glycogen breakdown (T/F)

PKB increases protein synthesis (T/F)

PKB phosphorylates Glycogen Synthase Kinase (T/F)

PDK1 directly phosphorylates PKB (T/F)

What allows the different proteins to bind to T.K?