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where does iron from making new RBCs come from?
what causes iron deficiency in males?
what is the result In acute blood loss, where there is a sudden loss of 25-30% of the total blood volume
what is the result of a loss of 30-40% of the total blood volume?
With the sudden loss of 40-50% of the total blood volume, the result is?
ferritin is?
define asynchronism?
what is intrinsic factor and what is its function?
where is B12, Folate, and iron stored?
what does peripheral blood look like in aplastic anemia?
what does peripheral blood look like in renal disease?
what are the signs of lead poisoning?
who is more likely to get lead poisoning?
what is the etiology (cause) of iron deficiency anemia?
what is the pathophysiology (sign/symptom) of iron deficiency anemia?
what does the peripheral blood look like in iron deficiency anemia?
what does the bone marrow look like in iron deficiency anemia?
what does the iron stores look like in iron deficiency anemia?
CBC results in iron deficiency anemia?
what does peripheral blood look like in megaloblastic anemia
what does the bone marrow look like in megaloblastic anemia?
what is the etiology of megaloblastic anemia?
what is the pathophysiology of megaloblastic anemia?
CBC results of megaloblastic anemia look like?
What are cabot bodies?
what are heinz bodies?
what are pappenheimer bodies?
what are basophilic stippling?
what are Howell-Jolly bodies?
what is Hemoglobin C disease?
What is Hemoglobin SC disease?
what is congenital dyserythropoietic anemia?
classify iron deficiency anemia?
classify sideroblastic anemia?
classify anemia of chronic disease?
classify lead toxicity anemia?
classify B12 deficiency anemia?
classify folate deficiency anemia?
classify liver disease?
classify hypthyroidism (myxedema)?
classify aplastic anemia?
classify dysplastic anemia?
classify refractory anemia?
classify myelophthistic anemia?
classify cytotoxic drug anemia?
classify post hemorrhagic anemia?
classify chronic blood loss anemia?
classify congenital dyserythropoietic anemia?
classify renal disease anemia?
classify endocrine disease anemia?
what are stromatocytes?
what is Hyperchromasia?
what is Anisocytosis?
what are spherocytes?
when would you see microcytosis?
when would you see macrocytosis?
What are codocytes (target cells)?
what are Drepanocytes (sickle cells)?
what are Crenated cells?
what are echinocytes (blur cells)?
what are acanthrocytes (spur cells)?
what are schistocytes?
what are ovalocytes/elliptocytes?
what are dacryocytes (tear drop)?
what is the etiology of inherited sideroblastic anemia?
what is the pathophysiology of inherited sideroblastic anemia?
CBC results in inherited sideroblastic anemia?
what does the peripheral blood look like in inherited sideroblastic anemia?
what does the bone marrow look like in inherited sideroblastic anemia?
what do the iron studies look like for sideroblastic anemia?
CBC results in Idiopathic sideroblastic anemia (AKA refractory anemia) look like?
what does the bone marrow look like in Idiopathic sideroblastic anemia (AKA refractory anemia)?
what do the iron studies in Idiopathic sideroblastic anemia (AKA refractory anemia) show?
what is the etiology in secondary siderblastic anemia?
CBC results in secondary sideroblastic anemia show?
peripheral blood in all three sideroblastic anemias show?
bone marrow in secondary sideroblastic anemia shows?
iron studies in secondary sideroblastic anemia show?
what do the iron studies in anemia of chronic disease show?
CBC results in anemia of chronic disease show?
pathophysiology of anemia of chronic disease?
etiology of anemia of chronic disease?
peripheral blood in anemia of chronic disease shows?
bone marrow in anemia of chronic disease shows?
which erythrocyte inclusions are composed of aggregated denatured hemoglobin and stain with supravital stains but not with Romanowsky stains?
a patient with anemia has an RPI of 2.3 with an MCV of 103 fl. how would you classify this anemia?
a blood smear reveals uneven distribution of blood cells. the cells appear to be stacked together like a stack of coins. how would you describe this distribution?
which of the following tests will give information about rate of erythrocyte destruction?
a patient has the following results: RBC count 2.5; Hgb 5.3; Hct 0.17; Retic count 1%. what are the absolute retic count and RPI?
what is the iron transport protein?
the term sideroblastic is most closely associated with which anemia?
the basic defect in sideroblastic anemia is?
describe hemosiderosis?
what anemia would be expected from: MCV normal, serum iron decreased, serum ferritin normal, TIBC and % saturation decreased?
the most common cause of macrocytosis is?
in the majority of cases, b12 deficiency is due to a deficiency of?
if you saw hypersegmented neutrophils, what anemia would you suspect?
increases in urinary excretion of formiminoglutamic acid would most likely indicate what condition?
the liver stores enough folate to meet daily requirement needs for how long?
what affect does pregnancy have on someones vitamin b12 daily requirements?
a deficiency of vitamin b12 leads to impaired?
which laboratory test is used to diagnose pernicious anemia?
alcoholics commonly develop a macrocytic anemia due to?
anemia due to liver disease is often associated with which RBC morphological form?
a lack of IF may be due to?
what is more typical of non-megaloblastic than megaloblastic anemia?
the bone marrow in aplastic anemia is typically?
what are considered a cause of hypoproliferation in aplastic anemia?
diagnostic criteria for aplastic anemia includes a granulocyte count of?
what is DIC?
what is hemosiderin?
what is TIBC?
serum ferritin expected result is?
serum iron expected result is?
TIBC expected result is?
% ferritin saturation expected result is?
what does the peripheral blood show in pure red cell aplasia anemia?
what physical finding is associated with iron deficiency anemia?
what are koilonychias?
what does yellowness of the eyes suggest?
if a patient has a test that reveals antibodies and complement on his RBCs, what does this support?
what does the presence of spherocytes indicate?
what is a typical sign of spherocytes?
a high retic count and presence of polychromatophilic RBCs indicate what?
Case Study
The patient is a 62 year old Mexican-American male who was seen by his physician for an annual checkup. He had a CBC and comprehensive metabolic panel, lipid panel, ferritin, TIBC, serum iron and % saturation. Results were:
WBC 5.9 x 109/L
Hemoglobin 16.8 g/dL
Hematocrit 49.1%
RBC 5.08 x 1012/L
RDW 12.9
Differential: 47% neutrophils; 39% lymphocytes; 11% monocytes; 2% eosinophils; 1% basophils
Platelet count 176 x 109/L
Comprehensive metabolic panel: within reference range
Cholesterol 202 mg/dL
Serum ferritin: 390 ng/mL (12-282)
TIBC: 292 mg/dL (250-450)
Serum iron 166 mg/dL (35-158)
#1. Calculate the patient’s % iron saturation. Reference range at this facility is 20-50%. Saturation % = serum iron/TIBC
#2. Interpret the patient’s iron status.
#3. What condition is suggested with these results?
#4. The patient was sent to a hematologist who ordered genetic testing. Results showed a single heterozygous mutation at C282Y. There was no evidence of mutation of the H63D or S65C mutation. What do these genetic results mean?
#5. The patient donated a pint of blood every other week for 2 months. The physician ordered a repeat serum ferritin. The result was 218 (23-233). What was the rationale for the periodic phlebotomy? Why did the serum ferritin decrease?
#6. What is the risk of iron overload in the body?
MCV calculation?
MCH calculation?
MCHC calculation?
Absolute Retic Calculation?
RPI calculation?
which maturation time correlates with a Hct of 40-45%
which maturation time correlates with a Hct of 30-39%
which maturation time correlates with a Hct of 20-29%
which maturation time correlates with a Hct of less than 20?
