gina_evans0312
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Year 2 Quiz on Tyrosine Kinase, created by gina_evans0312 on 02/12/2013.

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Tyrosine Kinase

Question 1 of 8

1

When the ligand has bound, what moleucle forms?

Select one or more of the following:

  • A homodimer

  • A heterodimer within the T.K family

  • A heterotrimer within the T.K family

  • A homotrimer

Explanation

Question 2 of 8

1

What is found in the active site that inhibits activity?

Select one of the following:

  • A pseudosubstrate

  • An activation lip

  • A hydrophobic core that must be exposed

Explanation

Question 3 of 8

1

How do you activate the active site?

Select one of the following:

  • Phosphorylation

  • Acetylation

  • Methylation

Explanation

Question 4 of 8

1

Which residues of tyrosine kinase are modified?

Select one of the following:

  • Tyrosine

  • Serine

  • Threonine

Explanation

Question 5 of 8

1

What domain is required to bind to an activated Tyrosine Kinase?

Select one of the following:

  • Sh2

  • Sh4

  • SH3

Explanation

Question 6 of 8

1

How large is an SH2 domain?

Select one of the following:

  • 100 residues

  • 50 residues

  • 25 residues

Explanation

Question 7 of 8

1

How many pockets are there in SH2?

Select one of the following:

  • 1

  • 2

  • 3

Explanation

Question 8 of 8

1

How does a specific molecule know where to dock on a tyrosine kinase receptor?

Select one of the following:

  • The sequence of aa around the modification it binds to

  • The shape of the protein around the modification it binds to

Explanation

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