Liz Maas
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Liz Maas
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Development of the CNS and Related Birth Defects (CF9)

Question 1 of 12

1

The three vesicle stage occurs at the 3rd week of gestation. The five vesicle stage occurs at the 5th week of gestation

Select one of the following:

  • both true

  • first true second false

  • first false second true

  • both false

Explanation

Question 2 of 12

1

The Prechodal plate produces FGF to regulate midline structure development of the brain and face. The Anterior Neural Ridge produces SHH to regulate development of the telencephalon.

Select one of the following:

  • Both statements true

  • First true, second false

  • First false, second true

  • Both statements false

Explanation

Question 3 of 12

1

The prechodal plate is derived from?

Select one of the following:

  • Ectoderm

  • Mesoderm

  • Endoderm

  • Dermis

Explanation

Question 4 of 12

1

The isthmus is between the forebrain and midbrain and regulates their development. It produces both FGF and WNT.

Select one of the following:

  • Both statements true

  • First true, second false

  • First false, second true

  • Both false

Explanation

Question 5 of 12

1

Some neurons from the corpus striatum gives rise to part of the cerebral cortex. Most of the cerebral cortex comes from the pallium.

Select one of the following:

  • Both statements true

  • First true, second false

  • First false, second true

  • Both false

Explanation

Question 6 of 12

1

Which of the following is a vertebral fusion defect where both the neural tissue and meninges protrude?

Select one of the following:

  • spina bifida occulta

  • meningocele

  • meningomyelocele

  • myeloschisis

  • Arnold-Chiari malformation

Explanation

Question 7 of 12

1

Which of the following is incorrectly matched?

Select one of the following:

  • Spina Bifida occulta: the bony defect is covered by skin, intact spinal cord

  • Spina Bifida Cystica: there is a protrusion of meninges and neural tissue (meningomyelocele)

  • Meningocele: only the meninges protrude

  • Anencephaly- open brain

  • Craniorachischisis: neural tube defect at the brain and spinal cord

Explanation

Question 8 of 12

1

In normal development, the spinal cord elongates faster than the vertebral column. In Spina Bifida Cystica, as the vertebral column elongates, the force stretches the spinal cord which causes the herniation of the cerebellum.

Select one of the following:

  • Both statements true

  • First true, second false

  • First false, second true

  • Both false

Explanation

Question 9 of 12

1

The bone most frequently affected by neural tube defects is the occipital bone. Small defects can cause meningoencephalocele.

Select one of the following:

  • Both true

  • First true, second false

  • First false, second true

  • Both false

Explanation

Question 10 of 12

1

Meningoencephalocele is protrusion of just the brain tissue and meninges. Meningohydroencephalocele involves protrusion of the meninges, brain tissue and ventricle.

Select one of the following:

  • Both statements true

  • First true, second false

  • First false, second true

  • Both statements false

Explanation

Question 11 of 12

1

Which of the following is correct?

Select one of the following:

  • Lobar HPE- one telencephalic vesicle, one eye, one nasal chamber, other midline defects

  • Alobar HPE- one telencephalic vesicle, one eye, one nasal chamber, other midline defects

  • Smith-Lemli-Opitz involves EMX 2, is autosomal recessive, assorted defects of face, heart, brain, limbs

  • Schizencephaly- involves DHCR 7, causes large clefts in cerebral hemispheres

  • Microcephaly- caused by smaller cranial vault leading to less brain development

Explanation

Question 12 of 12

1

Hydrocephaly is often due to a blockage in the lateral and third ventricles. The accumulated fluid leads to thinner bones of skull and cerebral cortex and an enlarged head.

Select one of the following:

  • Both statements true

  • First true, second false

  • First false, second true

  • Both false.

Explanation

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