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6 Medicinal Chemistry Quiz on Cancer Chemotherapy, created by sbpharmacy on 24/04/2016.

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Cancer Chemotherapy

Question 1 of 51

1

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What is the scientific name for cancer?

Explanation

Question 2 of 51

1

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What is the word used for a cancerous growth?

Explanation

Question 3 of 51

1

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Carcinomas derive from

Explanation

Question 4 of 51

1

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What type of tumour derives from connective tissue?

Explanation

Question 5 of 51

1

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What type of tumour derives from thin layers of tissue surrounding internal organs?

Explanation

Question 6 of 51

1

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What type of tumour derives from glial cells in the brain?

Explanation

Question 7 of 51

2

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derive from germ cells (which are non- cells)

Explanation

Question 8 of 51

1

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What does leukemia derive from?

Explanation

Question 9 of 51

1

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The proportion of tumour cells dividing and cycling is known as the

Explanation

Question 10 of 51

3

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Name three folic acid antagonists.
1 -
2 -
3 -

Explanation

Question 11 of 51

4

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Name four pyrimidine analogues.
1 -
2 -
3 -
4 -

Explanation

Question 12 of 51

5

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Name five purine analogues.
1 -
2 -
3 -
4 -
5 -

Explanation

Question 13 of 51

3

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Methotrexate works by attacking/inhibiting reductase. This prevents being converted into .

Explanation

Question 14 of 51

1

Fluorouracil mimics which nitrogenous base?

Select one of the following:

  • cytosine

  • guanine

  • thiamine

  • adenine

Explanation

Question 15 of 51

2

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Name two main nitrogen mustard based alkylating agents.
1 -
2 -

Explanation

Question 16 of 51

5

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Alkylating agents, such as , work by between nitrogenous bases. This produces a structure which is hard to break meaning DNA is not longer able to .

Explanation

Question 17 of 51

1

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Cisplatin and carboplatin are examples of which anticancer type drugs?

Explanation

Question 18 of 51

2

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Name two platinating agents.
1 -
2 -

Explanation

Question 19 of 51

1

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Which main element do platinating agents contain?

Explanation

Question 20 of 51

4

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In conditions, the group of platinating agents is replaced with . The nitrogen on the base can displace water and binds tightly to the drug.

Explanation

Question 21 of 51

1

The bond formed by platinating agents and DNA bases is stronger than the covalent bonds formed between alkylating agents and DNA bases.

Select one of the following:

  • True
  • False

Explanation

Question 22 of 51

1

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Antitumor antibiotics and derived from species.

Explanation

Question 23 of 51

6

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Name six main groups/drugs of antibiotics used in cancer chemotherapy (in alphabetical order).
1 -
2 -
3 -
4 -
5 -
6 -

Explanation

Question 24 of 51

1

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The main anticancer anthracycline antibiotic is .

Explanation

Question 25 of 51

1

Anthracyclines are used mainly in lung, breast cancer, and leukaemia.

Select one of the following:

  • True
  • False

Explanation

Question 26 of 51

1

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Which enzyme does doxorubicin inhibit?

Explanation

Question 27 of 51

1

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What is the main adverse effect of anthracyclines?

Explanation

Question 28 of 51

1

Dactinomycin is used mainly for breast, stomach, lung, pancreas, bladder, and anal cancers.

Select one of the following:

  • True
  • False

Explanation

Question 29 of 51

4

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Dactinomycin works mainly by with DNA at the complex, which prevents action.

Explanation

Question 30 of 51

1

Bleomycin is used mainly for treatment of Hodgkin's lymphoma, and non-Hodgkin's lymphoma.

Select one of the following:

  • True
  • False

Explanation

Question 31 of 51

5

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Bleomycin works by with ions (mainly ), which produces that DNA. Oxygen is required for this to occur.

Explanation

Question 32 of 51

1

Dactinomycin causes pulmonary fibrosis and dermatological toxicity.

Select one of the following:

  • True
  • False

Explanation

Question 33 of 51

2

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Mitomycin C is a . It is enzymatically activated to produce an metabolite.

Explanation

Question 34 of 51

1

Procarbazine is used mainly in the treatment of Hodgkin's lymphoma.

Select one of the following:

  • True
  • False

Explanation

Question 35 of 51

6

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Procarbazine is a which breaks down to in the body. This reaction produces which causes damage to . It interferes with DNA and RNA .

Explanation

Question 36 of 51

1

Hydroxycarbamide interacts with many drugs because it inhibits monoamine oxidase.

Select one of the following:

  • True
  • False

Explanation

Question 37 of 51

1

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is used for the treatment of chronic myelogenous leukaemia.

Explanation

Question 38 of 51

1

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Hydroxycarbamide works by inhibiting . This enzyme is responsible for catalysing DNA from RNA strands.

Explanation

Question 39 of 51

1

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What is the main side effect of hydroxycarbamide?

Explanation

Question 40 of 51

5

ABVD is the name of one the chemotherapy treatments used to treat . It is made up of the drugs
A =
B =
C =
D =

Drag and drop to complete the text.

    Hodgkin's lymphoma
    testicular cancer
    non-Hodgkin's lymphoma
    breast cancer
    bladder cancer
    brain tumours
    Adriamycin
    Amsacrine
    Alemtuzumab
    Aromasin
    Aclarubicin
    Bleomycin
    Busulfan
    Buserelin
    Bevacizumab
    Vinblastine
    Vectibix
    Viadur
    Vincristine
    Vindesine
    Vinorelbine
    Dacarbazine
    Doxorubicin
    Daunorubicin
    Dactinomycin

Explanation

Question 41 of 51

4

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Name four plant derived cancer therapy agents.
1. C
2. E
3. T
4. V a

Explanation

Question 42 of 51

1

Vinca alkaloids are derived from Madagascar Periwinkle.

Select one of the following:

  • True
  • False

Explanation

Question 43 of 51

5

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Vinca alkaloids work by binding to . This prevents formation in mitosis. The disruption of stops mitosis in . Vinca alkaloids affect all dividing cell types.

Explanation

Question 44 of 51

1

Vincristine is used in the treatment of non-Hodgkin's lymphoma and Hodgkin's lymphoma.

Select one of the following:

  • True
  • False

Explanation

Question 45 of 51

1

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The brand name for vincristine is

Explanation

Question 46 of 51

2

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Name two taxane drugs.
1.
2.

Explanation

Question 47 of 51

1

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Taxanes work by stabilising preventing .

Explanation

Question 48 of 51

1

Camptothecins inhibits topoisomerase I

Select one of the following:

  • True
  • False

Explanation

Question 49 of 51

1

Etoposide inhibits topoisomerase I

Select one of the following:

  • True
  • False

Explanation

Question 50 of 51

1

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Name two camptothecins.
1. t
2. i

Explanation

Question 51 of 51

1

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Name six anthracyclines (other than doxorubicin)
1 - a
2 - a
3 - d
4 - e
5 - i
6 - m

Explanation

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