Molecular Theraputics (molecular theraputics) Flashcards on Molecular Theraputics, created by lumen7 on 22/04/2013.
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Created by lumen7
over 11 years ago
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Created by lumen7
over 11 years ago
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current molecular therapies undergoing trials for cancer treatment
Sleeping beauty transposons; a non-viral vector for gene therapy
major problem with adenoviruses as vectors
advantages of retroviruses as viral vectors
disadvantages of retroviruses as vectors
advantages and disadvantages of adenoassociated viruses as vectors
somatic germline therapy
germline therapy
2 types of gene therapy
liposomes as vector
antibodies as vectors
particle bombardment as vector
ligands as vectors
take home message re gene augmentation therapy
tissues targeted for gene augmentation therapy
major problems with gene augmentation therapy
criteria for gene therapy
what type of viral vectors available for gene therapy?
non viral vectors for gene therapy
problems with human organs for donations
problems with animal organs for human use
what are the general problems with organs for donation
what types of recombinant protiens may be used in theraputic strategies?
adenoviruses as vectors
how to engineer transgenic pig for xenotransplantation
5 molecular therapies for the treatment of cancer
an example of recombinant protien therapy for cancer treatment
an example of organ transplant for cancer treatment
an example of how stem cells are used for cancer treatment
describe reproductive stem cell therapy
describe theraputic stem cell therapy
list 6 potential problems associated with production of a theraputic monoclonal antibody
name 6 vector properties important in human gene therapy
what is a SNP?
(single nucleotide polymorphism)
Where do most SNPS occur?
what happens when a SNP occurs within the coding sequence?
how often to SNPs occur?
how many common SNPs are there?
what responses do SNPs affect? (5)
how are SNPs useful in drug therapy?
how would poor and rapid metabolisers respond to a prodrug like codiene?
how would poor/rapid metabolisers respond to an active drug like omeprazole?
what would be the impact of global testing for SNPs?
antidepressants and SNPs
problems associate with production of recombinant protiens (9)
what are 2 vector types for human gene therapy?
