In these situations, antibiotic therapy should be started on admission to hospital for labour or rupture of membranes, ideally at least 4 hours before delivery, and continued until the neonate is delivered.

Recommended intra-partum antibiotic therapy:

· IV benzylpenicillin 3 g dose followed by 1.8g 4 hourly until delivery

OR If penicillin hypersensitivity (excluding immediate hypersensitivity), IV cephazolin 2 g dose 8 hourly until delivery
OR If immediate penicillin hypersensitivity and GBS isolate known to be susceptible to clindamycin, IV clindamycin 600 mg 8-hourly until delivery
OR If immediate penicillin hypersensitivity and GBS isolate resistant to clindamycin or results of susceptibility testing are not available, IV vancomycin

	Created by Abhijit Das over 8 years ago

Fellowship Obstetrics Note on Antibiotics in obstetrics, created by Abhijit Das on 12/07/2016.