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Year 2 (Insulin & Glucagon) Quiz on Beta Cells and Insulin, created by gina_evans0312 on 04/03/2014.

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Beta Cells and Insulin

Question 1 of 19

1

Pre-Proinsulin contains an R.E.R signal that moves it to the golgi

Select one of the following:

  • True
  • False

Explanation

Question 2 of 19

1

What is the role of the C-peptide part of the insulin chain

Select one of the following:

  • Formation of disulphide bonds between the alpha and beta chains

  • Formation of Fe-S bonds between the alpha and beta chains

  • Formation of peptide bonds between the alpha and beta chains

Explanation

Question 3 of 19

1

Pro-insulin is made of the alpha & beta chains and the c peptide

Select one of the following:

  • True
  • False

Explanation

Question 4 of 19

1

Which of the following cleave the c-peptide from the proinsulin?

Select one or more of the following:

  • Endopeptidase

  • Enteropeptidase

  • Carboxypeptidase

Explanation

Question 5 of 19

1

What form does newly made insulin take?

Select one of the following:

  • Granules

  • Crystals

  • Rods

Explanation

Question 6 of 19

1

The cleaved C-peptide is released along with the insulin

Select one of the following:

  • True
  • False

Explanation

Question 7 of 19

1

Why do Mannoheptulases inhibit insulin release?

Select one of the following:

  • The insulin secretion system relies on the phosphorylation of glucose, which MHLs inhibit

  • MHLs block excretory channels

  • MHLs prevent the movement of insulin to the RER

Explanation

Question 8 of 19

1

Optimum insulin secretion occurs at 8mM

Select one of the following:

  • True
  • False

Explanation

Question 9 of 19

1

Why is optimal secretion of insulin at 8mM

Select one of the following:

  • GLUT 2 & glucokinase have Kms of 8

  • Not gonna put anything else

  • Because reasons

Explanation

Question 10 of 19

1

Insulin secretion relies on ATP dependent K+ channels

Select one of the following:

  • True
  • False

Explanation

Question 11 of 19

1

K+ buildup causes Ca2+ influx and insulin secretion

Select one of the following:

  • True
  • False

Explanation

Question 12 of 19

1

Which drugs block K+ channels and mimic high glucose?

Select one of the following:

  • Sulpynoylurea

  • Sulphinomides

  • Sulphinomics

Explanation

Question 13 of 19

1

Diazoxide causes insulin secretion by keeping channels open

Select one of the following:

  • True
  • False

Explanation

Question 14 of 19

1

High doses of adrenaline stimulates insulin secretion through _ receptors

Select one of the following:

  • Alpha 1

  • Alpha 2

  • Beta 1

  • Beta 2

Explanation

Question 15 of 19

1

Low concs of adrenaline inhibit insulin secretion through Beta receptors

Select one of the following:

  • True
  • False

Explanation

Question 16 of 19

1

Insulin is catabolic

Select one of the following:

  • True
  • False

Explanation

Question 17 of 19

1

Insulin stimulates _ activity in order to reduce cAMP levels

Select one of the following:

  • Phosphodiesterases

  • Adenylate cyclase

Explanation

Question 18 of 19

1

Which of the following metabolites are reduced?

Select one or more of the following:

  • Fatty Acyl CoA

  • Acetyl CoA

  • Malonyl CoA

  • Palmitite

Explanation

Question 19 of 19

1

Inc. Phosphorylation of tyrosine kinase by insulin causes what?

Select one or more of the following:

  • Inc tyrosine kinase activity

  • Inc phosphatase activity

  • Inc Adenylate cyclase activity

Explanation

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