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(1819)
An expansion of federal powers
Said that the Necessary and Proper Clause (Article 1, Section 8, Clause 18) gave Congress the flexibility to create a National Bank as an aid to carrying out its enumerated borrowing and taxing powers and that Maryland's taxation of the bank violated the Supremacy Clause (Article 6, Clause 2)
Laid the groundwork for a significantly more significant federal government!
Answered a pivotal question about who would be the “most equal”
This is especially important in terms of both the size and scope of the federal government and in terms of the balance of powers