Therapeutic approach to immune mediated disease

What is stearic hinderence?

Which cytokine produced by the innate immune response is released in rheumatoid arthritis/peridontal disease.

What is the name of IL-1betas normal receptor?

Describe how decoy receptors can regulate IL-1B

What additional way can IL-1R2 help control IL-1Beta concentrations?

What does IL-1Ra do?

Is control of IL-1beta specific or broad ranging?

Why might anti TNF-a antibodies cause problems?

Why would you want to control TNF-a in the first place?

Describe the action of corticosteriod mimics?

What affect do glucocorticoids have on NFkB?

If a drug has an increased mineralocorticoid effect what would be the outcome?

Is immunosupression by corticosteroids specific or broad ranging?

Which drug is more potent? Dexamethasone or prednisolone?

How do NSAIDs work?

Which Cox is responsible for production of Pgs?

Why must you give NSAIDs with food?

What is an action of PGE2?

How are CD4+ lymphocyte populations controlled?

What affect does thromboxane have?

What is the name of the group which has prostaglandins and thromboxanes in it?

GIve some examples of some neutroceuticals?