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Pip Barton
Mind Map by , created more than 1 year ago

Infection Mind Map on STI's, created by Pip Barton on 08/05/2013.

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Pip Barton
Created by Pip Barton almost 12 years ago
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STI'sSYPHILISTreponomaPallidumInfectionTrendsAgeGeographySexualorientationGramnegativeAxialfilaments1. PrimaryChancre2. Secondary4-6 wksFeverRashLiverinfectionSwollen lymphnodes3.TertiaryGummaSoft granularlesionCongenitalSkin lesionsDeafnessBonemalformationDiagnosisMicroscopySerologicaltestingTreatmentChemotherapeuticSalvarsanAntibioticPenicillinImmuneevasionCell wallAntibioticresistanceImmunecomplexesInflammationTissuedestructionTpr outer membraneproteinPhasevariationPoly G tract<8 =transcribed>8 = reducedtranscriptionStrand slippage and excisionrepairTpr KAntigenicvariationCHLAMYDIAGONORRHOEAEChlamydiaTrachomatisSymptomsMalesEpididymisinflammationPainful urination, waterdischargeFemalesCervicalinflammationPainful urination, vaginaldischargePIDFallopian tubeadhesionsInfertilityEctopicpregnancyAIDsInfantsChlamydialophthalmiaChlamydialpneumoniaTrachomaCorneal scarringand blindnessDiagnosisPCRImmunoassaysTreatmentDoxycyclinGramnegativeSmallgenomeCell wallCross linked membraneproteinsMOMP2 stage lifecycleReticulatebodyElementarybodyInfectionReplicationCell cycle1.AttachmentOmpA binds heparansulphate2.EntryT3SS injectsTARPInducesuptake3.PrimarydifferentiationEB to RB4.CelldivisionRapidmultiplication5.EffectorsecretionCPAFDegrade hostTF's6.Secondarydifferentiation7.EB releaseRB to EB (Intermediateform)ChromosomalcondensationOMCformationT3SSformationImmuneactivationInfected cells secrete IL's andGM-CSFAttract immunecellsFibrosis andscarringNeisseria GonorrhoeaeGramnegativediplococcusOxidasepositive2nd mostcommonSymptomsFemalesVaginaldischargeAbdominalpainBurning peeUrinal ouchy pee peetimesPIDMalesBurning peepeePusdischargeEpididymitisNeonatesGonoccocalopthalmiaDiagnosisMicroscopyThayer MartinagarInhibits mostothersImmunoassaysPCRTreatment3rd gencephalosporinsVirulencemechanismsAttachmentpiliType4T2SSBinds CR3and CD46TightattachmentsTransformationDNA bindingUptakeRecA mediatedrecombinationOpa proteinsOpaHSOpaCEABinds heparinsulphateBinds CEACAMUptakeChange surfaceproteinsRecombinationAntigenicvariationTransformationAbberantrecombinationGeneexchangePilE and PilS exchangeE for expressedGenetic recombination between homologous segmentsPilS and PilE unequal exchangeL-pilinStuck in periplasmEvades immune system recognitionS-pilinSecreted soluble pilin molecular decoyPhase variationHomopolymeric repeatsTetranucleotide repeatsPilC11-12G = off<11->12 = onCTTCT repeats3,6,9,12 = onSialylated lipopolysaccharideResistant to complement and antibodiesMimics host cell surfaceOmpAChronic inflammatory responseOpa proteinsDouble click this nodeto edit the textClick and drag this buttonto create a new node