Mer Scott
Quiz by , created more than 1 year ago

• Outline the sequence of events that results in the secretion of growth hormone. • Describe the metabolic effects of growth hormone on each type of target cell. • Describe the effects of growth hormone on human growth (during the growth years and after skeletal fusion) • Explain what occurs when there is too much or too little growth hormone secreted during childhood.

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Mer Scott
Created by Mer Scott over 7 years ago
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L35: Growth Hormone

Question 1 of 18

1

What percent of cells in the anterior pituitary are somatotrophs, which produce growth hormone?

Select one of the following:

  • 50%

  • 20%

  • 70%

  • 95%

Explanation

Question 2 of 18

1

Choose the incorrect statements.

Select one or more of the following:

  • 20% of the cells in the anterior pituitary gland are mammotrophs.

  • 20% of the cells in the anterior pituitary gland are corticotrophs.

  • 50% of the cells in the anterior pituitary gland are thyrotrophs.

  • 5% of the cells in the anterior pituitary gland are somatotrophs.

Explanation

Question 3 of 18

1

SS stands for:

Select one of the following:

  • Somatostatin

  • Somastatin

  • Somatostatic

Explanation

Question 4 of 18

1

Somatotrophin is another name for growth hormone.

Select one of the following:

  • True
  • False

Explanation

Question 5 of 18

1

Growth hormone has been able to be produced in vitro since 1979.

Select one of the following:

  • True
  • False

Explanation

Question 6 of 18

1

Select from the dropdown lists to complete the text.

Growth hormone is a ( peptide, protein ) hormone. It is ( small, long ) (191 amino acids). The secretion of GH is ( pulsatile, continuous ) and has a ( daily, hourly ) rhythm which differs between males and females.

Explanation

Question 7 of 18

1

Growth hormone's half life in the blood is 20-25 minutes.

Select one of the following:

  • True
  • False

Explanation

Question 8 of 18

1

Growth hormone is an exception for hormones because it travels in the .

Drag and drop to complete the text.

    peptide
    protein
    blood bound to a protein carrier
    without a protein carrier

Explanation

Question 9 of 18

1

Growth hormone releasing hormone neurons (GHRH neurons) in the are excited and release into the anterior pituitary gland where it stimulates to release growth hormone (GH). GH is released into the bloodstream where it stimulates production in the .
IGF-1 feeds back to the hypothalamus where it more release of GHRH and stimulates to inhibit release of by the anterior pituitary gland.

Drag and drop to complete the text.

    hypothalamus
    GHRH
    somatotrophs
    insulin-like growth factor (IGF-1)
    liver
    inhibits
    somatostatin (SS)
    GH

Explanation

Question 10 of 18

1

Choose the correct statements.

Select one or more of the following:

  • Growth hormone release peaks during the night and settles down during the day, but is constantly spiking.

  • The growth hormone secretion peak is less pronounced for males.

  • Release of GH increases with age until it peaks at puberty.

  • The puberty peak of GH release occurs earlier for females than males.

Explanation

Question 11 of 18

1

Growth hormone is essential for until around age 8, rapid growth of in two separate periods, and growth of around puberty.

Drag and drop to complete the text.

    brain development
    height
    reproductive organs

Explanation

Question 12 of 18

1

Growth hormone receptor is a single molecule found in the membrane that does not require activation.

Select one of the following:

  • True
  • False

Explanation

Question 13 of 18

1

Which of these is not a long term effect of growth hormone?

Select one of the following:

  • Stimulation of bone and muscle growth

  • Stimulation of mitogenesis (cell division) via IGF-1

  • Stimulation of protein synthesis (in liver)

Explanation

Question 14 of 18

1

Stimulation of mitogenesis via IGF-1 is a direct effect of growth hormone.
Stimulation of protein synthesis in muscle by is an indirect effect of growth hormone.

Select one of the following:

  • True
  • False

Explanation

Question 15 of 18

1

Short term effects of growth hormone are always direct.

Select one of the following:

  • True
  • False

Explanation

Question 16 of 18

1

Choose the correct effects of GH on metabolism(short term effects).

Select one or more of the following:

  • Increase in blood glucose by stimulating glucose synthesis (in
    liver)

  • Increase in blood glucose by stimulating cellular uptake of glucose

  • Decrease in triglyceride breakdown in adipose tissue

  • Free fatty acid mobilisation in adipose tissue

Explanation

Question 17 of 18

1

Other hormones important for are thyroid hormones, insulin, cortisol, and estrogen/testosterone.
Thyroid hormone the basal metabolic rate and is essential for development.
Insulin and increase metabolism.
Estrogen/testosterone are essential during .

Drag and drop to complete the text.

    growth
    increases
    nervous system
    glucose
    puberty
    cortisol

Explanation

Question 18 of 18

1

Endocrine disorders can be due to too little GH () or too much GH ().
An of GH can cause gigantism or acromegaly. Acromegaly is an excess of GH in which leads to thickening of , and of soft tissues in the hands, feet and face. A can cause dwarfism.
Endocrine disorders can also result from an issue in the GH . Hyposensitive receptors to GH and the effects are similar to hyposecretion. Hypersensitive receptors to GH and have similar effects to hypersecretion.

Drag and drop to complete the text.

    hyposecretion
    hypersecretion
    excess
    adulthood
    childhood
    bones
    muscles
    deficiency
    receptors
    give little or no response
    overreact

Explanation

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